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Dominique Mengin-Lecreulx

Dominique Mengin-Lecreulx

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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
16355
World Ranking
5726
National Ranking
166

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Dominique Mengin-Lecreulx is affiliated with the University of Paris-Saclay in France. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine as well. The scientist has published extensively in subfields including genetics, molecular biology, infectious diseases, microbiology, and molecular medicine.

Their research addresses several key topics such as:

  • Bacterial Genetics and Biotechnology
  • Clostridium difficile and Clostridium perfringens research
  • Antibiotic Resistance in Bacteria
  • Reproductive tract infections research
  • Bacteriophages and microbial interactions
  • Enzyme Structure and Function
  • RNA and protein synthesis mechanisms

Dominique Mengin-Lecreulx has contributed to multiple recent papers, including the following:

  • "An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis" (2023, PLoS Pathogens)
  • "MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa" (2021, International Journal of Molecular Sciences)
  • "Insight into the dual function of lipid phosphate phosphatase PgpB involved in two essential cell-envelope metabolic pathways in Escherichia coli" (2020, Scientific Reports)
  • "AsnB is responsible for peptidoglycan precursor amidation in Clostridium difficile in the presence of vancomycin" (2020, Microbiology)
  • "A Francisella tularensis L,D-carboxypeptidase plays important roles in cell morphology, envelope integrity, and virulence" (2021, Molecular Microbiology)

The scientist frequently collaborates with other researchers, with notable coauthors including:

  • Guillaume Manat
  • Thierry Touzé
  • Delphine Patin
  • Jula Reuter
  • Christian Otten

Dominique Mengin-Lecreulx's research has been published in diverse scientific journals, with repeated contributions to venues such as:

  • PLoS Pathogens
  • International Journal of Molecular Sciences
  • Scientific Reports
  • Molecular Microbiology
  • Frontiers in Microbiology

Best Publications

  • Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

    Stephen E. Girardin;Leonardo H. Travassos;Mireille Hervé;Didier Blanot

  • The Drosophila immune system detects bacteria through specific peptidoglycan recognition.

    François Leulier;Claudine Parquet;Sebastien Pili-Floury;Ji-Hwan Ryu

  • The biosynthesis of peptidoglycan lipid‐linked intermediates

    Ahmed Bouhss;Amy E. Trunkfield;Timothy D.H. Bugg;Dominique Mengin-Lecreulx

  • The Drosophila Amidase PGRP-LB Modulates the Immune Response to Bacterial Infection

    Anna Zaidman-Rémy;Mireille Hervé;Mickael Poidevin;Sébastien Pili-Floury

  • Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

    Jörg H. Fritz;Stephen E. Girardin;Catherine Fitting;Catherine Werts

  • Ampd, Essential for Both Beta-Lactamase Regulation and Cell Wall Recycling, Is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase

    Christine Jacobs;Bernard Joris;M. Jamin;K. Klarsov

  • Cytoplasmic steps of peptidoglycan synthesis in Escherichia coli.

    D Mengin-Lecreulx;B Flouret;J van Heijenoort

  • Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis.

    D Mengin-Lecreulx;J van Heijenoort

  • The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis.

    D Mengin-Lecreulx;L Texier;M Rousseau;J van Heijenoort

  • The bacA Gene of Escherichia coli Encodes an Undecaprenyl Pyrophosphate Phosphatase Activity

    Meriem El Ghachi;Ahmed Bouhss;Didier Blanot;Dominique Mengin-Lecreulx

  • Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily

    Kieron Brown;Fredérique Pompeo;Suzanne Dixon;Dominique Mengin‐Lecreulx

  • Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan.

    Sophie Magnet;Samuel Bellais;Samuel Bellais;Samuel Bellais;Lionel Dubost;Martine Fourgeaud;Martine Fourgeaud;Martine Fourgeaud

  • Characterization of the Essential Gene glmM Encoding Phosphoglucosamine Mutase in Escherichia coli(

    Dominique Mengin-Lecreulx;Jean van Heijenoort

  • Synergistic enhancement of Toll-like receptor responses by NOD1 activation.

    David A. van Heel;Subrata Ghosh;Matt Butler;Karen Hunt

  • Identification of Multiple Genes Encoding Membrane Proteins with Undecaprenyl Pyrophosphate Phosphatase (UppP) Activity in Escherichia coli

    Meriem El Ghachi;Anne Derbise;Ahmed Bouhss;Dominique Mengin-Lecreulx

  • Purification and Characterization of the Bacterial MraY Translocase Catalyzing the First Membrane Step of Peptidoglycan Biosynthesis

    Ahmed Bouhss;Muriel Crouvoisier;Didier Blanot;Dominique Mengin-Lecreulx

  • Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli.

    D Mengin-Lecreulx;J van Heijenoort

  • Crystal Structure of UDP-N-acetylmuramoyl-l-alanyl-d-glutamate:meso-Diaminopimelate Ligase from Escherichia Coli

    Elspeth Gordon;Bernard Flouret;Laurent Chantalat;Jean van Heijenoort

  • Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin.

    Joao Gamelas Magalhaes;Dana J Philpott;Marie-Anne Nahori;Muguette Jéhanno

  • Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis

    Ahmed Bouhss;Dominique Mengin‐Lecreulx;Dominique Le Beller;Jean Van Heijenoort

Frequent Co-Authors

Didier Blanot
Didier Blanot University of Paris-Saclay
Michel Arthur
Michel Arthur Centre de Recherche des Cordeliers
Bruno Lemaitre
Bruno Lemaitre École Polytechnique Fédérale de Lausanne
Stanislav Gobec
Stanislav Gobec University of Ljubljana
Ivo G. Boneca
Ivo G. Boneca Institut Pasteur
Scott A. Lesley
Scott A. Lesley Genomics Institute of the Novartis Research Foundation
Adam Godzik
Adam Godzik University of California, Riverside
Bernard Joris
Bernard Joris University of Liège
Stephen E. Girardin
Stephen E. Girardin University of Toronto
Ian Chopra
Ian Chopra University of Leeds

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