World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
56
Citations
8705
World Ranking
11905
National Ranking
3195

Biology and Biochemistry

D-Index
56
Citations
8713
World Ranking
14670
National Ranking
6135

Overview

James T. Stivers is affiliated with the Johns Hopkins University School of Medicine in the United States. Their research expertise spans multiple fields related to biochemistry, molecular biology, and medicine, focusing primarily on molecular and infectious disease mechanisms.

Their scientific contributions cover a range of topics, including:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • DNA repair mechanisms
  • HIV research and treatment
  • DNA and nucleic acid chemistry
  • Advanced biosensing and bioanalysis techniques
  • HIV/AIDS research and interventions

James T. Stivers has published extensively in the areas of molecular biology and infectious diseases, with numerous articles appearing in noted scientific venues. Their frequent publication outlets include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Biochemistry
  • Molecular Pharmacology

Among their recent scientific papers are:

  • Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil, 2021, Molecular Pharmacology
  • Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics, 2022, Nucleic Acids Research
  • Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP, 2022, Retrovirology
  • Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages, 2020, PLoS ONE
  • Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding, 2023, ACS Chemical Biology

Collaboration is a notable aspect of their work, with frequent coauthors including:

  • Benjamin Orris
  • Seungil Han
  • David J. Shields
  • Shridhar Bhat
  • Junru Cui

Their research intersects multiple scientific domains, primarily concentrated on biochemistry, genetics, and molecular biology, supported by a substantial number of publications. The subfields they contribute to include molecular biology, infectious diseases, virology, emergency medicine, and materials chemistry.

Best Publications

  • A mechanistic perspective on the chemistry of DNA repair glycosylases.

    James T. Stivers;Yu Lin Jiang

  • AID/APOBEC Deaminases Disfavor Modified Cytosines Implicated in DNA Demethylation

    Christopher S Nabel;Huijue Jia;Yu Ye;Li Shen

  • Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase.

    James T. Stivers;Krzysztof W. Pankiewicz;Kyoichi A. Watanabe

  • 2-Aminopurine fluorescence studies of base stacking interactions at abasic sites in DNA: metal-ion and base sequence effects

    James T. Stivers

  • Enzymatic capture of an extrahelical thymine in the search for uracil in DNA

    Jared B. Parker;Mario A. Bianchet;Daniel J. Krosky;Joshua I. Friedman

  • Detection of damaged DNA bases by DNA glycosylase enzymes.

    Joshua I. Friedman;James T. Stivers

  • Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine.

    E. L. Rachofsky;E. Seibert;J. T. Stivers;R. Osman

  • Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils

    Rishi H. Porecha;James T. Stivers

  • Kinetic isotope effect studies of the reaction catalyzed by uracil DNA glycosylase: Evidence for an oxocarbenium ion - Uracil anion intermediate

    Werner Rm;Stivers Jt

  • Dynamic opening of DNA during the enzymatic search for a damaged base.

    Chunyang Cao;Yu Lin Jiang;James T Stivers;Fenhong Song

  • SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

    Kyle J. Seamon;Zhiqiang Sun;Luda S. Shlyakhtenko;Yuri L. Lyubchenko

  • A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

    Rahul M. Kohli;Shaun R. Abrams;Kiran S. Gajula;Robert W. Maul

  • Vaccinia DNA topoisomerase I : single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions

    James T. Stivers;Stewart Shuman;Albert S. Mildvan

  • Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy.

    Karen A. Lacourciere;James T. Stivers;John P. Marino

  • 4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues.

    James T. Stivers;Chitrananda Abeygunawardana;Albert S. Mildvan;Gholamhossein Hajipour

  • Impact of linker strain and flexibility in the design of a fragment-based inhibitor

    S Chung;J.B Parker;M Bianchet;L.M Amzel

  • Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.

    Gaoyi Xiao;Maria Tordova;Jaya Jagadeesh;Alexander C. Drohat

  • Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.

    Alexander C. Drohat;Jayashree Jagadeesh;Eric Ferguson;James T. Stivers

  • Vaccinia DNA topoisomerase I: evidence supporting a free rotation mechanism for DNA supercoil relaxation.

    James T. Stivers;Thomas K. Harris;Albert S. Mildvan

  • 15N NMR relaxation studies of free and inhibitor-bound 4- oxalocrotonate tautomerase: Backbone dynamics and entropy changes of an enzyme upon inhibitor binding

    James T. Stivers;Chitrananda Abeygunawardana;Albert S. Mildvan;Christian P. Whitman

Frequent Co-Authors

Albert S. Mildvan
Albert S. Mildvan Johns Hopkins University
Robert F. Siliciano
Robert F. Siliciano Johns Hopkins University School of Medicine
Philip A. Cole
Philip A. Cole Brigham and Women's Hospital
Peter C.M. van Zijl
Peter C.M. van Zijl Kennedy Krieger Institute
Patricia J. Gearhart
Patricia J. Gearhart National Institutes of Health
L. Mario Amzel
L. Mario Amzel Johns Hopkins University School of Medicine
Gary L. Gilliland
Gary L. Gilliland National Institute of Standards and Technology
Stewart Shuman
Stewart Shuman Memorial Sloan Kettering Cancer Center
Pawel Jaruga
Pawel Jaruga National Institute of Standards and Technology
Janet D. Siliciano
Janet D. Siliciano Johns Hopkins University School of Medicine

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