World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
8666
World Ranking
17238
National Ranking
7094

Overview

Patricia J. Gearhart is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on immunology and microbiology, encompassing 37 publications, with additional work spanning medicine.

Their detailed study areas include immunology, molecular biology, epidemiology, rheumatology, and oncology. The main research topics covered by Gearhart include T-cell and B-cell immunology, immune cell function and interaction, influenza virus research studies, immunotherapy and immune responses, atherosclerosis and cardiovascular diseases, systemic lupus erythematosus research, and genomics and chromatin dynamics.

Patricia J. Gearhart has published extensively in a variety of scientific venues. Frequent publication venues are:

  • The Journal of Immunology (12 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • Frontiers in Immunology (3 publications)
  • mBio (1 publication)
  • Immunity & Ageing (1 publication)

The following are recent papers featuring Patricia J. Gearhart's contributions:

  • Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection, 2021, Frontiers in Immunology
  • Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells, 2022, mBio
  • Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice, 2021, Frontiers in Immunology
  • Antibodies in action: the role of humoral immunity in the fight against atherosclerosis, 2022, Immunity & Ageing
  • From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptorαand RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus, 2020, Viral Immunology

Their frequent co-authors include:

  • Robert W. Maul (19 collaborations)
  • Sabra L. Klein (8 collaborations)
  • Andrew Pekosz (7 collaborations)
  • Han-Sol Park (6 collaborations)
  • Santosh Dhakal (5 collaborations)

Best Publications

  • IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.

    Patricia J. Gearhart;Nelson D. Johnson;Richard Douglas;Leroy Hood

  • Different B cell populations mediate early and late memory during an endogenous immune response

    Kathryn A. Pape;Justin J. Taylor;Robert W. Maul;Patricia J. Gearhart

  • DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

    Xianmin Zeng;David B. Winter;Cynthia Kasmer;Kenneth H. Kraemer

  • Clusters of point mutations are found exclusively around rearranged antibody variable genes.

    Patricia J. Gearhart;Daniel F. Bogenhagen

  • AID AND SOMATIC HYPERMUTATION

    Robert W. Maul;Patricia J. Gearhart

  • MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes

    Teresa M. Wilson;Alexandra Vaisman;Stella A. Martomo;Patsa Sullivan

  • A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

    Stella A. Martomo;William W. Yang;Patricia J. Gearhart

  • Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice

    Joanne M. Lumsden;Thomas McCarty;Lisa K. Petiniot;Rhuna Shen

  • 129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

    John P. McDonald;Ekaterina G. Frank;Brian S. Plosky;Igor B. Rogozin

  • The Generation of Diversity in Phosphorylcholine-Binding Antibodies

    Roger M. Perlmutter;Stephen T. Crews;Richard Douglas;Greg Sorensen

  • Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

    Patricia J. Gearhart;Nolan H. Sigal;Norman R. Klinman

  • Different mutation signatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification

    Stella A. Martomo;William W. Yang;Robert P. Wersto;Tsuyoshi Ohkumo

  • A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

    Rahul M. Kohli;Shaun R. Abrams;Kiran S. Gajula;Robert W. Maul

  • Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

    David B. Winter;Quy H. Phung;Quy H. Phung;Asad Umar;Sean M. Baker

  • Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions.

    Robert W Maul;Huseyin Saribasak;Stella A Martomo;Rhonda L McClure

  • Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load.

    Patricia J. Gearhart;John J. Cebra

  • Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.

    Karli Rosner;David B. Winter;Robert E. Tarone;Gunhild Lange Skovgaard

  • Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation.

    Lisa M. Russell Knode;Martin S. Naradikian;Arpita Myles;Jean L. Scholz

  • Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

    Ann M. Lawler;Paul S. Lin;Patricia J. Gearhart

  • Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

    Deepa Rajagopal;Deepa Rajagopal;Robert W. Maul;Amalendu Ghosh;Tirtha Chakraborty

Frequent Co-Authors

Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Norman R. Klinman
Norman R. Klinman Scripps Research Institute
Fumio Hanaoka
Fumio Hanaoka National Institute of Genetics
Roger Woodgate
Roger Woodgate National Institutes of Health
Richard D. Wood
Richard D. Wood The University of Texas MD Anderson Cancer Center
Susan K. Pierce
Susan K. Pierce National Institute of Allergy and Infectious Diseases
Robert E. Tarone
Robert E. Tarone Vanderbilt University Medical Center
James T. Stivers
James T. Stivers Johns Hopkins University School of Medicine
Igor B. Rogozin
Igor B. Rogozin National Institutes of Health
Tomas Lindahl
Tomas Lindahl The Francis Crick Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a degree in Biology or Biochemistry in the USA opens up a wide range of opportunities in rapidly growing healthcare and science fields. Many students consider both traditional and online pathways to gain the knowledge and credentials necessary for their careers.

If you are interested in nutrition and health, the top dietetics programs in the US provide advanced training in food science, clinical nutrition, and health promotion. For those wanting to enter the healthcare workforce quickly, accredited online medical assistant programs with financial aid can help launch your medical career while managing costs.

If you are currently a Medical Assistant, there are flexible ma to lpn bridge program options available online, allowing you to expand your scope of practice and career prospects. For those wanting to deepen their foundation in the life sciences, an online bachelor's degree in biology offers convenience, flexibility, and strong job market relevance.

By exploring these related online degrees and pathways, you can tailor your educational journey to fit your career goals in Biology, Biochemistry, and broader healthcare fields.

Best Scientists Citing Patricia J. Gearhart

Trending Scientists