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Gregory L. Verdine

Gregory L. Verdine

D-Index & Metrics

Biology and Biochemistry

D-Index
96
Citations
35822
World Ranking
1807
National Ranking
998

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1991 - Fellow of Alfred P. Sloan Foundation

Overview

Gregory L. Verdine is affiliated with Harvard University in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a specialized focus on Molecular Biology, Genetics, Oncology, Computational Theory and Mathematics, and Radiology, Nuclear Medicine and Imaging.

The main topics addressed in Verdine's work include:

  • Protein Degradation and Inhibitors
  • Chemical Synthesis and Analysis
  • Glycosylation and Glycoproteins Research
  • Signaling Pathways in Disease
  • RNA and protein synthesis mechanisms
  • DNA and Nucleic Acid Chemistry
  • Ubiquitin and proteasome pathways

Verdine has published extensively, with notable papers such as:

  • "Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface," 2020, Proceedings of the National Academy of Sciences
  • "Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins," 2024, Nature Communications
  • "The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase," 2020, Nature Communications
  • "De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries," 2022, Proceedings of the National Academy of Sciences
  • "Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides," 2023, Nature Communications

Frequent coauthors of Verdine include:

  • John H. McGee
  • Seung-Joo Lee
  • Tara L. Travaline
  • Kunhua Li
  • Sorabh Agarwal

The primary publication venues for Verdine's research are:

  • Nature Communications
  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Molecular Therapy - Nucleic Acids
  • Journal of Peptide Science

Regarding recognitions, Verdine was named Fellow of the American Association for the Advancement of Science (AAAS) in 2013 and was a Fellow of the Alfred P. Sloan Foundation in 1991.

Best Publications

  • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.

    Huifang Huang;Rajiv Chopra;Gregory L. Verdine;Stephen C. Harrison

  • Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

    Loren D. Walensky;Andrew L. Kung;Andrew L. Kung;Iris Escher;Thomas J. Malia;Thomas J. Malia

  • An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

    Christian E. Schafmeister;and Julia Po;Gregory L. Verdine

  • Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

    Steven D. Bruner;Derek P. G. Norman;Gregory L. Verdine

  • The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.

    Jain J;McCaffrey Pg;Miner Z;Miner Z;Kerppola Tk

  • Direct inhibition of the NOTCH transcription factor complex

    Raymond E. Moellering;Raymond E. Moellering;Melanie Cornejo;Tina N. Davis;Cristina Del Bianco

  • Regulation of MLL1 H3K4 methyltransferase activity by its core components

    Yali Dou;Thomas A Milne;Alexander J Ruthenburg;Alexander J Ruthenburg;Seunghee Lee

  • Structure of the NF-kappa B p50 homodimer bound to DNA.

    Christoph W. Müller;Félix A. Rey;Mikiko Sodeoka;Mikiko Sodeoka;Gregory L. Verdine

  • Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA

    Maria Tomasz;Roselyn Lipman;Dondapati Chowdary;Jan Pawlak

  • Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

    Federico Bernal;Andrew F. Tyler;Stanley J. Korsmeyer;Loren D. Walensky

  • Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

    Huw M. Nash;Steven D. Bruner;Orlando D. Schärer;Tomohiko Kawate

  • A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA

    Paul C. Blainey;Antoine M. van Oijen;Anirban Banerjee;Gregory L. Verdine

  • Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

    Patricia G. McCaffrey;Chun Luo;Tom K. Kerppola;Jugnu Jain

  • Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

    Young-Woo Kim;Tom N Grossmann;Gregory L Verdine

  • The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing

    Karin M. Reinisch;Lin Chen;Gregory L. Verdine;William N. Lipscomb

  • DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe

    Jeffrey A. Yoder;Neilesh S. Soman;Gregory L. Verdine;Timothy H. Bestor

  • Stapled peptides for intracellular drug targets.

    Gregory L. Verdine;Gerard J. Hilinski

  • A Stapled BID BH3 Helix Directly Binds and Activates BAX

    Loren D. Walensky;Kenneth Pitter;Joel Morash;Kyoung Joon Oh

  • STRUCTURE OF A REPAIR ENZYME INTERROGATING UNDAMAGED DNA ELUCIDATES RECOGNITION OF DAMAGED DNA

    Anirban Banerjee;Wei Yang;Martin Karplus;Gregory L. Verdine

  • The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.

    Gregory L Verdine;Loren D Walensky

Frequent Co-Authors

Loren D. Walensky
Loren D. Walensky Harvard University
Martin Karplus
Martin Karplus Harvard University
Lin Chen
Lin Chen University of Chicago
Orlando D. Schärer
Orlando D. Schärer Institute for Basic Science
Stanley J. Korsmeyer
Stanley J. Korsmeyer Harvard University
Gerhard Wagner
Gerhard Wagner Harvard University
Koji Nakanishi
Koji Nakanishi Columbia University
Maria Tomasz
Maria Tomasz City University of New York
William S. Lane
William S. Lane Harvard University
James E. Bradner
James E. Bradner Amgen (United States)

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