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Jean Paul Vonsattel

Jean Paul Vonsattel

Overview

Jean Paul Vonsattel is affiliated with Columbia University in the United States. Their research primarily focuses on fields related to Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these areas, Vonsattel's work concentrates on subfields such as Neurology, Molecular Biology, Physiology, Cellular and Molecular Neuroscience, and Psychiatry and Mental Health.

The main topics addressed in Vonsattel's research include:

  • Alzheimer's disease research and treatments
  • Genetic Neurodegenerative Diseases
  • Neurological disorders and treatments
  • Mitochondrial Function and Pathology
  • Amyotrophic Lateral Sclerosis Research
  • Dementia and Cognitive Impairment Research
  • Neurological diseases and metabolism

Vonsattel has contributed to multiple scientific articles published across a range of venues, with frequent publications in:

  • Nature Communications
  • Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Alzheimer's & Dementia

Selected recent publications featuring Vonsattel's work include:

  • Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease, 2020, Nature Communications
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study, 2020, Nature Communications
  • Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study, 2021, Alzheimer's & Dementia
  • Single-nucleus RNA-seq identifies Huntington disease astrocyte states, 2020, Acta Neuropathologica Communications
  • Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis, 2020, Neuron

Frequent co-authors collaborating with Vonsattel include:

  • Andrew F. Teich
  • Xena Flowers
  • Vilas Menon
  • Lawrence S. Honig
  • Richard A. Hickman

Best Publications

  • Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

    Marian DiFiglia;Ellen Sapp;Kathryn O. Chase;Stephen W. Davies

  • Neuropathological classification of Huntington's disease.

    Jean-Paul Vonsattel;Richard H. Myers;Thomas J. Stevens;Robert J. Ferrante

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Rapid induction of Alzheimer A beta amyloid formation by zinc.

    Ashley I. Bush;Warren H. Pettingell;Gerd Multhaup;Marc D. Paradis

  • Primary age-related tauopathy (PART): a common pathology associated with human aging

    John F. Crary;John Q. Trojanowski;Julie A. Schneider;Jose F. Abisambra

  • Trinucleotide repeat length instability and age of onset in Huntington's disease

    M Duyao;C Ambrose;R Myers;A Novelletto

  • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.

    Minghua Chen;Victor O. Ona;Mingwei Li;Robert J. Ferrante

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

    Heng Du;Lan Guo;Fang Fang;Doris Chen

  • Inactivation of the mouse Huntington's disease gene homolog Hdh.

    Mabel P. Duyao;Anna B. Auerbach;Angela Ryan;Francesca Persichetti

  • Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

    Victor O. Ona;Mingwei Li;Jean Paul G. Vonsattel;L. John Andrews

  • The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

    Ann C. McKee;Nigel J. Cairns;Dennis W. Dickson;Rebecca D. Folkerth

  • Office of Rare Diseases neuropathologic criteria for corticobasal degeneration.

    Dennis W. Dickson;C. Bergeron;S. S. Chin;C. Duyckaerts

  • Frequency and course of mild cognitive impairment in a multiethnic community

    Jennifer J. Manly;Mingxin Tang;Nicole Schupf;Yaakov Stern

  • CAG repeat number governs the development rate of pathology in Huntington's disease

    John B. Penney;Jean‐Paul Vonsattel;Marcy E. Macdonald;James F. Gusella

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.

    Thomas J. Grabowski;Hyun Soon Cho;Jean Paul G. Vonsattel;G. William Rebeck

  • Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.

    Jacqueline K. White;Wojtek Auerbach;Mabel P. Duyao;Jean-Paul Vonsattel

  • Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy.

    S. M. Greenberg;G. W. Rebeck;J. P. G. Vonsattel;J. P. G. Vonsattel;T. Gomez-Isla

  • Neuropathological changes in essential tremor: 33 cases compared with 21 controls

    Elan D. Louis;Phyllis L. Faust;Jean Paul G. Vonsattel;Lawrence S. Honig

Frequent Co-Authors

Elan D. Louis
Elan D. Louis The University of Texas Southwestern Medical Center
Lawrence S. Honig
Lawrence S. Honig Columbia University
Richard Mayeux
Richard Mayeux Columbia University
Sheng-Han Kuo
Sheng-Han Kuo Columbia University Medical Center
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Bernardino Ghetti
Bernardino Ghetti Indiana University
Marla Gearing
Marla Gearing Emory University
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Peter St George-Hyslop
Peter St George-Hyslop Columbia University

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