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D-Index & Metrics

Neuroscience

D-Index
48
Citations
18173
World Ranking
6077
National Ranking
2656

Overview

Sheng-Han Kuo is affiliated with Columbia University Medical Center in the United States and has contributed extensively to the fields of medicine and neuroscience, with a strong focus on neurology and cellular and molecular neuroscience. Their research has addressed several core areas, including genetic neurodegenerative diseases, neurological disorders and treatments, mitochondrial function and pathology, Parkinson's disease mechanisms and treatments, vestibular and auditory disorders, neuroscience and neuropharmacology research, as well as botulinum toxin and related neurological disorders.

Their recent significant publications include:

  • Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology, 2020, Science Translational Medicine
  • Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy, 2022, Science Advances
  • Cerebellar Volume Is Associated with Cognitive Decline in Mild Cognitive Impairment: Results from ADNI, 2020, The Cerebellum
  • Spinocerebellar ataxia clinical trials: opportunities and challenges, 2021, Annals of Clinical and Translational Neurology
  • Current and emerging treatment modalities for spinocerebellar ataxias, 2022, Expert Review of Neurotherapeutics

Frequent co-authors in Sheng-Han Kuo's publications include Ming-Kai Pan, Chi-Ying Lin, Jeremy D. Schmahmann, Elan D. Louis, and Tetsuo Ashizawa. Collaborations with these researchers have resulted in a considerable number of joint studies, contributing to advancing understanding in neurodegenerative and neurological research.

The venues where Sheng-Han Kuo has most frequently published reflect the clinical and research depth of their work. These include:

  • The Cerebellum
  • Neurology
  • Annals of Clinical and Translational Neurology
  • International Review of Neurobiology
  • Journal of the Neurological Sciences

Sheng-Han Kuo's research spans topics that intersect clinical neurology and molecular biological mechanisms, focusing heavily on the cellular and genetic bases of neurodegenerative diseases. Their work particularly explores the pathogenic mechanisms underlying conditions such as Parkinson's disease and spinocerebellar ataxias, as well as therapeutic approaches aimed at modulating disease pathways. This includes studies on synaptic pruning deficits, autophagy interruption, and cognitive decline associated with cerebellar structure changes.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

    Guomei Tang;Kathryn Gudsnuk;Sheng-Han Kuo;Marisa L. Cotrina;Marisa L. Cotrina

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Glucocerebrosidase activity in Parkinson’s disease with and without GBA mutations

    Roy N. Alcalay;Oren A. Levy;Cheryl H. Waters;Stanley Fahn

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

    Chris M. Woodard;Brian A. Campos;Sheng-Han Kuo;Melissa J. Nirenberg

  • Mitochondrial abnormalities in temporal lobe of autistic brain

    Guomei Tang;Puri Gutierrez Rios;Sheng-Han Kuo;Hasan Orhan Akman

  • Resveratrol alleviates MPTP‐induced motor impairments and pathological changes by autophagic degradation of α‐synuclein via SIRT1‐deacetylated LC3

    Yan-Jie Guo;Su-Yan Dong;Xin-Xin Cui;Ya Feng

  • Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; A prospective observational study

    Tetsuo Ashizawa;Karla P Figueroa;Susan L Perlman;Christopher M Gomez

  • Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms

    Dane M. Chetkovich;Robert C. Bunn;Sheng Han Kuo;Yoshimi Kawasaki

  • Consensus Paper: Experimental Neurostimulation of the Cerebellum

    Lauren L.N. Miterko;Kenneth K.B. Baker;Jaclyn Beckinghausen;Lynley L.V. Bradnam

  • Comprehensive systematic review summary: Treatment of cerebellar motor dysfunction and ataxia: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

    Theresa A. Zesiewicz;George Wilmot;Sheng-Han Kuo;Susan Perlman

  • The cerebellum does more than sensory prediction error-based learning in sensorimotor adaptation tasks

    Peter A. Butcher;Richard B. Ivry;Sheng Han Kuo;David Rydz

  • Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology

    Ming Kai Pan;Yong Shi Li;Shi Bing Wong;Chun Lun Ni

  • Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum.

    Chi Ying Lin;Elan D. Louis;Phyllis L. Faust;Arnulf H. Koeppen

  • SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease

    Roy N. Alcalay;Victoria Mallett;Benoît Vanderperre;Omid Tavassoly

  • Depression and clinical progression in spinocerebellar ataxias

    Raymond Y. Lo;Karla P. Figueroa;Stefan M. Pulst;Susan Perlman

  • AMPA Receptor Synaptic Targeting Regulated by Stargazin Interactions with the Golgi-Resident PDZ Protein nPIST

    Adolfo E. Cuadra;Sheng Han Kuo;Yoshimi Kawasaki;David S. Bredt

  • Increased number of heterotopic Purkinje cells in essential tremor

    Sheng Han Kuo;Cordelia Erickson-Davis;Arthur Gillman;Phyllis L. Faust

  • Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis

    Matthew Choe;Etty Cortés;Jean Paul G. Vonsattel;Sheng Han Kuo

Frequent Co-Authors

Elan D. Louis
Elan D. Louis The University of Texas Southwestern Medical Center
Stefan M. Pulst
Stefan M. Pulst University of Utah
Tetsuo Ashizawa
Tetsuo Ashizawa Houston Methodist
Jeremy D. Schmahmann
Jeremy D. Schmahmann Harvard Medical School
Vikram G. Shakkottai
Vikram G. Shakkottai The University of Texas Southwestern Medical Center
David Sulzer
David Sulzer Columbia University
Un Jung Kang
Un Jung Kang New York University
Wendy K. Chung
Wendy K. Chung Columbia University
Ziv Gan-Or
Ziv Gan-Or McGill University
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital

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