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Biology and Biochemistry

D-Index
51
Citations
26340
World Ranking
16912
National Ranking
6969

Overview

Edward A. Miao is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research output spans multiple areas within biochemistry, genetics, molecular biology, immunology, and microbiology. They have contributed substantially to studies addressing immune system mechanisms and molecular biology of cell death and infectious diseases.

The main fields of study represented in Edward A. Miao's work include:

  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Within these fields, their research often focuses on specific subfields such as:

  • Molecular Biology
  • Immunology
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Epidemiology

Their published topics cover a range of immunological and molecular mechanisms, including:

  • Inflammasome and immune disorders
  • Interferon and immune responses
  • Streptococcal Infections and Treatments
  • Cell death mechanisms and regulation
  • Phagocytosis and Immune Regulation
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Microbial Metabolism and Applications

Edward A. Miao has frequently published in venues such as:

  • UNC Libraries
  • eLife
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Nature

Some recent representative publications list the scientist as an author or co-author and include:

  • "Caspase-7 activates ASM to repair gasdermin and perforin pores," 2022, Nature
  • "Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection," 2022, Annual Review of Immunology
  • "Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium," 2020, Cell Reports
  • "Pyroptosis in defense against intracellular bacteria," 2023, Seminars in Immunology
  • "The AIM2 inflammasome is activated in astrocytes during the late phase of EAE," 2022, JCI Insight

Collaborations are notable in Edward A. Miao's research career, with several frequent co-authors contributing to a significant portion of the work. These frequent collaborators include:

  • Lupeng Li
  • Carissa K. Harvest
  • Zachary P. Billman
  • Heather N. Larson
  • Youssef Aachoui

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

    Edward A Miao;Irina A Leaf;Piper M Treuting;Dat P Mao

  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

    Edward A Miao;Celia M Alpuche-Aranda;Monica Dors;April E Clark

  • Caspase-1-induced pyroptotic cell death.

    Edward A. Miao;Jayant V. Rajan;Jayant V. Rajan;Alan Aderem

  • Gasdermins: Effectors of Pyroptosis

    Stephen B. Kovacs;Edward A. Miao

  • Pyroptotic cell death defends against intracellular pathogens

    Ine Jorgensen;Edward A. Miao

  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

    Edward A. Miao;Dat P. Mao;Natalya Yudkovsky;Richard Bonneau

  • Programmed cell death as a defence against infection.

    Ine Jorgensen;Manira Rayamajhi;Edward A. Miao

  • Caspase-11 Protects Against Bacteria That Escape the Vacuole

    Youssef Aachoui;Irina A. Leaf;Jon A. Hagar;Mary F. Fontana

  • Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

    Haitao Wen;Edward A. Miao;Jenny P.-Y. Ting

  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

    Danielle M. Pilla;Jon A. Hagar;Arun K. Haldar;Ashley K. Mason

  • Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

    Kwong Tai Cheng;Shiqin Xiong;Zhiming Ye;Zhiming Ye;Zhigang Hong

  • Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

    Ine Jorgensen;Yue Zhang;Bryan A. Krantz;Edward A. Miao

  • TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.

    Edward A. Miao;Erica Andersen-Nissen;Erica Andersen-Nissen;Sarah E. Warren;Sarah E. Warren;Alan Aderem

  • A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium.

    Edward A. Miao;Samuel I. Miller

  • Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems.

    Edward A. Miao;Christina A. Scherer;Renée M. Tsolis;Robert A. Kingsley

  • Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

    Youssef Aachoui;Vitaliya Sagulenko;Edward A Miao;Katryn J Stacey

  • Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

    Takahiro Shimada;Bong Goo Park;Andrea J. Wolf;Constantinos Brikos

  • Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis.

    Renée M. Tsolis;Stacy M. Townsend;Edward A. Miao;Samuel I. Miller

  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.

    Makoto Inoue;Kristi L. Williams;Timothy Oliver;Peter Vandenabeele;Peter Vandenabeele

Frequent Co-Authors

Alan Aderem
Alan Aderem Seattle Children's Hospital
Samuel I. Miller
Samuel I. Miller University of Washington
Gyorgy Szabadkai
Gyorgy Szabadkai University College London
Peter Vandenabeele
Peter Vandenabeele Ghent University
Soman N. Abraham
Soman N. Abraham Duke University
Robert K. Ernst
Robert K. Ernst University of Maryland, Baltimore
Russell E. Vance
Russell E. Vance University of California, Berkeley
Catherine Brenner
Catherine Brenner Université Paris Cité
Simone Fulda
Simone Fulda Goethe University Frankfurt
Jenny P.-Y. Ting
Jenny P.-Y. Ting University of North Carolina at Chapel Hill

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