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Wolf-Dietrich Hardt

Wolf-Dietrich Hardt

D-Index & Metrics

Microbiology

D-Index
93
Citations
31956
World Ranking
587
National Ranking
13

Research.com Recognitions

  • 2018 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Microbiology and Immunology

Overview

Wolf-Dietrich Hardt is affiliated with ETH Zurich in Switzerland and has contributed extensively to research in Biochemistry, Genetics, and Molecular Biology with a focus on the intersection of microbiology and immunology. Their work encompasses molecular biology, endocrinology, food science, infectious diseases, and immunology, reflecting a multidisciplinary approach to microbial and host interactions.

The scientist's research topics include:

  • Gut microbiota and health
  • Salmonella and Campylobacter epidemiology
  • Escherichia coli research studies
  • Vibrio bacteria research studies
  • Probiotics and fermented foods
  • Antibiotic resistance in bacteria
  • Immune response and inflammation

Wolf-Dietrich Hardt has published multiple papers in reputed journals, with recent works including:

  • "Evolutionary causes and consequences of bacterial antibiotic persistence," 2020, Nature Reviews Microbiology
  • "Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo," 2020, The ISME Journal
  • "Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression," 2020, Mucosal Immunology
  • "Import of Aspartate and Malate by DcuABC Drives H2/Fumarate Respiration to Promote Initial Salmonella Gut-Lumen Colonization in Mice," 2020, Cell Host & Microbe
  • "Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice," 2021, Cell Host & Microbe

Frequent co-authors associated with Wolf-Dietrich Hardt include Bidong D. Nguyen, Stefan A. Fattinger, Shinichi Sunagawa, Mikael E. Sellin, and Julia A. Vorholt. Collaboration with these researchers has resulted in a significant number of publications.

The scientist tends to publish in several notable venues, with the highest number in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Host & Microbe
  • Nature Microbiology
  • PLoS Pathogens

Wolf-Dietrich Hardt received recognition from the German National Academy of Sciences Leopoldina in 2018 for work related to Microbiology and Immunology.

Best Publications

  • Phages and the Evolution of Bacterial Pathogens: from Genomic Rearrangements to Lysogenic Conversion

    Harald Brüssow;Carlos Canchaya;Wolf-Dietrich Hardt

  • Definitions and guidelines for research on antibiotic persistence

    Naomi N.Q. Balaban;Sophie Helaine;Kim Lewis;Martin Ackermann;Martin Ackermann

  • Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

    Manja Barthel;Siegfried Hapfelmeier;Siegfried Hapfelmeier;Leticia Quintanilla-Martínez;Marcus Kremer

  • Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

    Bärbel Stecher;Riccardo Robbiani;Alan W. Walker;Astrid M. Westendorf

  • S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

    Wolf Dietrich Hardt;Li Mei Chen;Kornel E. Schuebel;Xosé R. Bustelo

  • Intestinal lamina propria dendritic cell subsets have different origin and functions.

    Chen Varol;Alexandra Vallon-Eberhard;Eran Elinav;Eran Elinav;Tegest Aychek

  • The role of microbiota in infectious disease

    Bärbel Stecher;Wolf Dietrich Hardt

  • Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

    Emma Wetter Slack;Emma Wetter Slack;Siegfried Hapfelmeier;Siegfried Hapfelmeier;Bärbel Stecher;Yuliya Velykoredko

  • The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms

    Siegfried Hapfelmeier;Bärbel Stecher;Manja Barthel;Marcus Kremer

  • Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae.

    Bärbel Stecher;Rémy Denzler;Lisa Maier;Florian Bernet

  • Self-destructive cooperation mediated by phenotypic noise.

    Martin Ackermann;Bärbel Stecher;Nikki E. Freed;Pascal Songhet

  • Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria

    Bärbel Stecher;Samuel Chaffron;Rina Käppeli;Siegfried Hapfelmeier

  • Mechanisms controlling pathogen colonization of the gut

    Bärbel Stecher;Wolf-Dietrich Hardt

  • 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution

    Bärbel Stecher;Lisa Maier;Wolf-Dietrich Hardt

  • Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria.

    Carsten Schwan;Bärbel Stecher;Tina Tzivelekidis;Marco van Ham

  • Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa.

    Mikael E. Sellin;Anna A. Müller;Boas Felmy;Tamas Dolowschiak

  • High-avidity IgA protects the intestine by enchaining growing bacteria

    Kathrin Moor;Médéric Diard;Mikael E. Sellin;Mikael E. Sellin;Boas Felmy

  • Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell.

    Silke Stender;Andrea Friebel;Stefan Linder;Manfred Rohde

  • The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

    Kathrin Endt;Baerbel Stecher;Samuel Chaffron;Emma Slack

  • Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice.

    Bärbel Stecher;Siegfried Hapfelmeier;Catherine Müller;Marcus Kremer

Frequent Co-Authors

Bärbel Stecher
Bärbel Stecher Ludwig-Maximilians-Universität München
Christian von Mering
Christian von Mering University of Zurich
Christoph Dehio
Christoph Dehio University of Basel
Roland K. Hartmann
Roland K. Hartmann Philipp University of Marburg
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Andrew J. Macpherson
Andrew J. Macpherson University of Bern
Volker A. Erdmann
Volker A. Erdmann Freie Universität Berlin

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