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Andrew J. Macpherson

Andrew J. Macpherson

D-Index & Metrics

Immunology

D-Index
87
Citations
45241
World Ranking
1190
National Ranking
30

Overview

Andrew J. Macpherson is affiliated with the University of Bern in Switzerland. Their research focuses primarily on the intersection of medicine and biochemistry, genetics, and molecular biology. Throughout their career, they have contributed extensively to the fields of molecular biology, immunology, genetics, physiology, and epidemiology.

The main topics of Macpherson's work center on gut microbiota and health, with additional emphases on immune cell function and interaction, inflammatory bowel disease, neuroinflammation and neurodegeneration mechanisms, microscopic colitis, gastrointestinal motility and disorders, and the role of tryptophan in brain disorders.

Macpherson's recent publications illustrate these interests across several high-impact journals. Some of the notable papers include:

  • "Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease" (2021, Cell Metabolism)
  • "Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies" (2023, Nature)
  • "Neuronal programming by microbiota regulates intestinal physiology" (2020, Nature)
  • "Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition" (2021, eLife)
  • "Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells" (2020, Cell)

Frequent co-authors of Macpherson include:

  • Bahtiyar Yılmaz (21 collaborations)
  • Mercedes Gomez de Agüero (13 collaborations)
  • Stephanie C. Ganal-Vonarburg (13 collaborations)
  • Benjamin Misselwitz (10 collaborations)
  • Luc Biedermann (10 collaborations)

Their work has been published repeatedly in leading venues such as bioRxiv (Cold Spring Harbor Laboratory), with twelve publications, Nature with four, Immunity with four, Cell Host & Microbe with three, and Nature Communications with three.

Best Publications

  • Interactions between the microbiota and the immune system.

    Lora V. Hooper;Dan R. Littman;Andrew J. Macpherson

  • Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

    Andrew J. Macpherson;Therese Uhr

  • Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

    Janet G. M. Markle;Daniel N. Frank;Steven Mortin-Toth;Charles E. Robertson

  • Interactions between commensal intestinal bacteria and the immune system

    Andrew J. Macpherson;Nicola L. Harris

  • Immune adaptations that maintain homeostasis with the intestinal microbiota

    Lora V. Hooper;Andrew J. Macpherson;Andrew J. Macpherson

  • A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

    Andrew J. Macpherson;Dominique Gatto;Elizabeth Sainsbury;Gregory R. Harriman

  • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

    Jochen Hampe;Andrew Cuthbert;Peter J. P. Croucher;Muddassar M. Mirza

  • The maternal microbiota drives early postnatal innate immune development

    Mercedes Gomez de Agüero;Stephanie C. Ganal-Vonarburg;Tobias Fuhrer;Sandra Rupp

  • The immune geography of IgA induction and function

    Macpherson Aj;McCoy Kd;Johansen Fe;Brandtzaeg P

  • Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

    Bärbel Stecher;Riccardo Robbiani;Alan W. Walker;Astrid M. Westendorf

  • Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota.

    Karen Smith;Kathy D. McCoy;Andrew J. Macpherson

  • Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

    Markus B. Geuking;Markus B. Geuking;Julia Cahenzli;Julia Cahenzli;Melissa A.E. Lawson;Melissa A.E. Lawson;Derek C.K. Ng

  • Environmental triggers in IBD: a review of progress and evidence.

    Ashwin N. Ananthakrishnan;Charles N. Bernstein;Dimitrios Iliopoulos;Andrew Macpherson

  • Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

    Siegfried Hapfelmeier;Melissa A.E. Lawson;Emma Wetter Slack;Jorum K. Kirundi

  • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

    A Macpherson;U Y Khoo;I Forgacs;J Philpott-Howard

  • Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

    Emma Wetter Slack;Emma Wetter Slack;Siegfried Hapfelmeier;Siegfried Hapfelmeier;Bärbel Stecher;Yuliya Velykoredko

  • Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

    Filipe De Vadder;Estelle Grasset;Louise Mannerås Holm;Gérard Karsenty

  • Depletion of murine intestinal microbiota: Effects on gut mucosa and epithelial gene expression

    Dag Henrik Reikvam;Alexander Erofeev;Anders Sandvik;Vedrana Grcic

  • The outer mucus layer hosts a distinct intestinal microbial niche

    Hai Li;Julien Periclis Jean Limenitakis;Tobias Fuhrer;Markus Geuking

  • Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria

    Bärbel Stecher;Samuel Chaffron;Rina Käppeli;Siegfried Hapfelmeier

  • Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium

    Sandrine Brugiroux;Markus Beutler;Carina Pfann;Debora Garzetti

  • The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

    Mario M. Zaiss;Alexis Rapin;Luc Lebon;Lalit Kumar Dubey

Frequent Co-Authors

Kathy D. McCoy
Kathy D. McCoy University of Calgary
Gerhard Rogler
Gerhard Rogler University of Zurich
Ingvar Bjarnason
Ingvar Bjarnason King's College London
Bärbel Stecher
Bärbel Stecher Ludwig-Maximilians-Universität München
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Roland von Känel
Roland von Känel University of Zurich
Jochen Hampe
Jochen Hampe TU Dresden
Stefan Schreiber
Stefan Schreiber Kiel University
Christopher G. Mathew
Christopher G. Mathew King's College London

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