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Biology and Biochemistry

D-Index
50
Citations
15907
World Ranking
17428
National Ranking
749

Overview

Christophe Borg is affiliated with the Centre Hospitalier Universitaire de Besançon in France. Their research primarily focuses on the field of Medicine, with a significant emphasis on Oncology. Over the course of their career, they have contributed extensively to topics that include Colorectal Cancer Treatments and Studies, Cancer Immunotherapy and Biomarkers, and Genetic factors in colorectal cancer.

Their work spans a broad range of subfields such as Oncology, Surgery, Pulmonary and Respiratory Medicine, Pathology and Forensic Medicine, and Cancer Research. This diverse expertise has been reflected in numerous publications across various well-recognized venues.

  • Journal of Clinical Oncology
  • Annals of Oncology
  • Frontiers in Oncology
  • The Lancet Oncology
  • European Journal of Cancer

Christophe Borg has collaborated frequently with several researchers throughout their career. Notably, they have worked alongside Déwi Vernerey, François Ghiringhelli, Stéfano Kim, Olivier Bouché, and Angélique Vienot.

Their recent papers indicate engagement in multiple large-scale clinical trials and high-impact studies. Examples include:

  • Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial (2021, The Lancet Oncology)
  • Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial (2023, The Lancet Oncology)
  • Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial (2023, The Lancet)
  • Tislelizumab Versus Chemotherapy as Second-Line Treatment for Advanced or Metastatic Esophageal Squamous Cell Carcinoma (RATIONALE-302): A Randomized Phase III Study (2022, Journal of Clinical Oncology)
  • Nab-paclitaxel plus gemcitabine in patients with locally advanced pancreatic cancer (LAPACT): a multicentre, open-label phase 2 study (2020, The Lancet Gastroenterology & Hepatology)

Best Publications

  • Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial.

    Andrew X Zhu;Yoon-Koo Kang;Chia-Jui Yen;Richard S Finn

  • Human Leukocyte Antigen‐G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells

    Zohair Selmani;Abderrahim Naji;Ines Zidi;Benoit Favier

  • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

    Bernard Escudier;Thierry Dorval;Nathalie Chaput;Fabrice André

  • Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial

    Jaafar Bennouna;Javier Sastre;Dirk Arnold;Pia Österlund

  • EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer

    Alberto F. Sobrero;Joan Maurel;Louis Fehrenbacher;Werner Scheithauer

  • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

    Fanny Chalmin;Sylvain Ladoire;Grégoire Mignot;Julie Vincent

  • Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

    Erika Vacchelli;Yuting Ma;Elisa E. Baracco;Antonella Sistigu

  • NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs

    Christophe Borg;Abdelali Jalil;Diego Laderach;Kouji Maruyama

  • Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.

    Fanny Chalmin;Grégoire Mignot;Mélanie Bruchard;Mélanie Bruchard;Angélique Chevriaux

  • Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects

    Christophe Borg;Magali Terme;Julien Taïeb;Cédric Ménard

  • Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer

    Boris Guiu;Jean Michel Petit;Franck Bonnetain;Sylvain Ladoire

  • Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients

    Cédric Ménard;Jean-Yves Blay;Christophe Borg;Stefan Michiels

  • X-Chromosome Genetics and Human Cancer

    Alain Spatz;Christophe Borg;Jean Feunteun

  • Predictors of responses to immune checkpoint blockade in advanced melanoma.

    N Jacquelot;N Jacquelot;M P Roberti;D P Enot;S Rusakiewicz

  • Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity

    Jean-René Pallandre;Emilie Brillard;Gilles Créhange;Amandine Radlovic

  • Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

    Takouhie Mgrditchian;Tsolere Arakelian;Jérôme Paggetti;Muhammad Zaeem Noman

  • PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer.

    Magalie Dosset;Thaiz Rivera Vargas;Thaiz Rivera Vargas;Anaïs Lagrange;Anaïs Lagrange;Romain Boidot;Romain Boidot

  • Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiation in patients with locally advanced rectal cancer: Final results of PRODIGE 23 phase III trial, a UNICANCER GI trial.

    Thierry Conroy;Najib Lamfichekh;Pierre-Luc Etienne;Emmanuel Rio

  • PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

    Afag Asgarova;Kamal Asgarov;Yann Godet;Paul Peixoto

  • Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study.

    Franck Pagès;Thierry André;Julien Taieb;Déwi Vernerey

Frequent Co-Authors

François Ghiringhelli
François Ghiringhelli Centre Georges François Leclerc
Olivier Bouché
Olivier Bouché CHU de Reims
Julien Taieb
Julien Taieb Université Paris Cité
Thierry André
Thierry André Université Paris Cité
Pierre Tiberghien
Pierre Tiberghien University of Franche-Comté
Laurence Zitvogel
Laurence Zitvogel University of Paris-Saclay
Pierre Laurent-Puig
Pierre Laurent-Puig Université Paris Cité
Anne Caignard
Anne Caignard Grenoble Alpes University

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