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Immunology

D-Index
45
Citations
9065
World Ranking
4689
National Ranking
2116

Overview

Laurent Brossay is a researcher affiliated with Brown University in the United States. Their research primarily focuses on immunology, with contributions spanning subfields such as oncology, molecular biology, epidemiology, and surgery. The core areas of study include immune cell function and interaction, T-cell and B-cell immunology, cancer immunotherapy and biomarkers, IL-33, ST2, and ILC pathways, immunotherapy and immune responses, cytomegalovirus and herpesvirus research, and immune cells in cancer.

Brossay has published extensively in notable venues with multiple papers found in The Journal of Immunology. Other frequent publication venues include:

  • Nature Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Current Opinion in Immunology

Their recent papers showcase a focus on innate and adaptive immune mechanisms. Selected works include:

  • "Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells" (2021) - Nature Communications
  • "Natural killers or ILC1s? That is the question" (2020) - Current Opinion in Immunology
  • "Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells" (2020) - Cell Reports
  • "Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers" (2021) - OncoImmunology
  • "The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells" (2022) - Frontiers in Immunology

Brossay frequently collaborates with several researchers, reflecting a network of partnerships in their scientific work. Frequent coauthors include:

  • Samantha Borys
  • Shanelle P. Reilly
  • David Zemmour
  • Éric Vivier
  • Ian Magill

Their expertise lies within the intersection of immunology and medicine, with 46 publications specifically in immunology and microbiology, and 18 in medicine. Immunological research remains the dominant scientific focus, addressing pathways and cellular interactions important to immune response and cancer treatment modalities.

Best Publications

  • Targeting natural killer cells and natural killer T cells in cancer.

    Eric Vivier;Sophie Ugolini;Didier Blaise;Christian Chabannon

  • CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

    Laurent Brossay;Mariacristina Chioda;Nicolas Burdin;Yasuhiko Koezuka

  • NK cells and NKT cells in innate defense against viral infections.

    Christine A Biron;Laurent Brossay

  • Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

    Nicolas Burdin;Laurent Brossay;Yasuhiko Koezuka;Stephen T. Smiley

  • Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis

    Nicolas Burdin;Laurent Brossay;Mitchell Kronenberg

  • PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae

    Matthew Wolfgang;Peter Lauer;Hae Sun Park;Laurent Brossay

  • Cutting Edge: Priming of NK Cells by IL-18

    Julie Chaix;Marlowe S. Tessmer;Kasper Hoebe;Nicolas Fuséri

  • Glycolipid antigen processing for presentation by CD1d molecules

    Theodore I. Prigozy;Olga Naidenko;Pankaj Qasba;Dirk Elewaut

  • Mouse CD1 is mainly expressed on hemopoietic-derived cells.

    L Brossay;D Jullien;S Cardell;B C Sydora

  • CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms.

    Masahiko Amano;Nicole Baumgarth;Michael D. Dick;Laurent Brossay

  • Cutting Edge: Structural Requirements for Galactosylceramide Recognition by CD1-Restricted NK T Cells

    Laurent Brossay;Olga Naidenko;Nicolas Burdin;Jennifer Matsuda

  • Cutting Edge: Inhibitory Functions of the Killer Cell Lectin-Like Receptor G1 Molecule During the Activation of Mouse NK Cells

    Scott H. Robbins;Khuong B. Nguyen;Nobuaki Takahashi;Toshifumi Mikayama

  • Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets

    Laurent Brossay;Shabnam Tangri;Mark Bix;Susanna Cardell

  • Expansion and Contraction of the NK Cell Compartment in Response to Murine Cytomegalovirus Infection

    Scott H. Robbins;Marlowe S. Tessmer;Toshifumi Mikayama;Laurent Brossay

  • KLRG1 binds cadherins and preferentially associates with SHIP-1.

    Marlowe S. Tessmer;Céline Fugere;Frederik Stevenaert;Olga V. Naidenko

  • NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection

    Johnna D. Wesley;Marlowe S. Tessmer;Deanna Chaukos;Laurent Brossay

  • Cutting edge: Anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice

    Gudrun Szalay;Christoph H. Ladel;Carmen Blum;Laurent Brossay

  • Structural requirements for antigen presentation by mouse CD1.

    Nicolas Burdin;Laurent Brossay;Massimo Degano;Hiroshi Iijima

  • Salivary gland NK cells are phenotypically and functionally unique.

    Marlowe S. Tessmer;Emma C. Reilly;Laurent Brossay

  • Diverse CD1d-restricted reactivity patterns of human T cells bearing "invariant" AV24BV11 TCR.

    Christelle Couedel;Marie Alix Peyrat;Laurent Brossay;Yasuhiko Koezuka

Frequent Co-Authors

Mitchell Kronenberg
Mitchell Kronenberg University of California, San Diego
Eric Vivier
Eric Vivier Aix-Marseille University
Jacques Hébert
Jacques Hébert Université Laval
Cory Teuscher
Cory Teuscher University of Vermont
Jack R. Wands
Jack R. Wands Brown University
Dirk Elewaut
Dirk Elewaut Ghent University
Emmanuelle Jouanguy
Emmanuelle Jouanguy Necker-Enfants Malades Hospital
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Hilde Cheroutre
Hilde Cheroutre La Jolla Institute For Allergy & Immunology
Yasuhiko Koezuka
Yasuhiko Koezuka Vanderbilt University

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