His primary scientific interests are in Immunology, Microbiology, Innate immune system, Legionella pneumophila and Caspase 1. His research integrates issues of Pathophysiology and Programmed cell death in his study of Immunology. His biological study spans a wide range of topics, including Nitric oxide synthase and Nitric oxide.
His Innate immune system study frequently involves adjacent topics like Cell biology. His Legionella pneumophila research includes elements of Legionella, Secretion, NLRC4 and Signal transduction. His Caspase 1 study necessitates a more in-depth grasp of Inflammasome.
The scientist’s investigation covers issues in Inflammasome, Immunology, Microbiology, Innate immune system and Cell biology. In his study, which falls under the umbrella issue of Inflammasome, Tumor necrosis factor alpha is strongly linked to Proinflammatory cytokine. His work is dedicated to discovering how Immunology, Receptor are connected with Nod and Cytokine and other disciplines.
His Microbiology research is multidisciplinary, relying on both Legionella pneumophila, Bacteria and In vivo. His work in Innate immune system addresses subjects such as Virology, which are connected to disciplines such as Virulence. His Cell biology research includes themes of Cellular differentiation and Leishmania.
Inflammasome, Inflammation, Immunology, Cell biology and Innate immune system are his primary areas of study. Caspase 1 and NLRC4 are among the areas of Inflammasome where Dario S. Zamboni concentrates his study. He works mostly in the field of Caspase 1, limiting it down to concerns involving Legionella pneumophila and, occasionally, Repressor.
His work carried out in the field of Immunology brings together such families of science as Apoptosis, Peripheral blood mononuclear cell, Disease and Pathophysiology. His work deals with themes such as Pyroptosis, Caspase-11, Secretion and Receptor, which intersect with Cell biology. His Innate immune system research is multidisciplinary, incorporating perspectives in Host cell cytoplasm and Immunity.
His primary areas of study are Inflammasome, Immunology, Leishmania, Caspase 1 and Leishmaniasis. His Inflammasome study contributes to a more complete understanding of Inflammation. His research in Immunology intersects with topics in Peripheral blood mononuclear cell, Pathophysiology and In vivo.
While the research belongs to areas of Leishmania, Dario S. Zamboni spends his time largely on the problem of Innate immune system, intersecting his research to questions surrounding Immunity and Mucocutaneous zone. His study on Caspase 1 is mostly dedicated to connecting different topics, such as Legionella pneumophila. His Intracellular parasite study incorporates themes from Caspase 7, NLRC4, Microbiology, Flagellin and Effector.
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Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.
Tao Ren;Dario S Zamboni;Craig R Roy;William F Dietrich.
PLOS Pathogens (2006)
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Dario S Zamboni;Koichi S Kobayashi;Koichi S Kobayashi;Tiana Kohlsdorf;Yasunori Ogura.
Nature Immunology (2006)
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Flavio Protasio Veras;Marjorie Cornejo Pontelli;Camila Meirelles Silva;Juliana E Toller-Kawahisa.
Journal of Experimental Medicine (2020)
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.
Djalma S Lima-Junior;Diego L Costa;Vanessa Carregaro;Larissa D Cunha.
Nature Medicine (2013)
A Method for Generation of Bone Marrow-Derived Macrophages from Cryopreserved Mouse Bone Marrow Cells
Fernanda M. Marim;Tatiana N. Silveira;Djalma S. Lima;Dario S. Zamboni.
PLOS ONE (2010)
Hemolysis-induced lethality involves inflammasome activation by heme
Fabianno F. Dutra;Letícia S. Alves;Danielle Rodrigues;Patricia L. Fernandez.
Proceedings of the National Academy of Sciences of the United States of America (2014)
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
Christopher L. Case;Lara J. Kohler;Jonilson B. Lima;Till Strowig.
Proceedings of the National Academy of Sciences of the United States of America (2013)
NOD1 and NOD2 Signaling in Infection and Inflammation.
Lilian O. Moreira;Dario S. Zamboni.
Frontiers in Immunology (2012)
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
Flávio A. Amaral;Vivian V. Costa;Livia D. Tavares;Daniela Sachs.
Arthritis & Rheumatism (2012)
Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system
Dario S. Zamboni;Susan McGrath;Michel Rabinovitch;Craig R. Roy.
Molecular Microbiology (2003)
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