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Bernhard Ryffel

Bernhard Ryffel

D-Index & Metrics

Immunology

D-Index
108
Citations
49768
World Ranking
529
National Ranking
14

Medicine

D-Index
108
Citations
49773
World Ranking
5940
National Ranking
171

Overview

Bernhard Ryffel is affiliated with the University of Orléans in France. The research focus spans multiple fields including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their work covers several subfields such as Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, Physiology, and Surgery.

The scientist has contributed extensively to topics related to inflammasome and immune disorders, IL-33, ST2, and ILC pathways, immune response and inflammation, immune cell function and interaction, interstitial lung diseases and idiopathic pulmonary fibrosis, interferon and immune responses, and asthma and respiratory diseases.

Bernhard Ryffel's publication record includes frequent contributions to several key venues, notably Frontiers in Immunology with 14 publications, Revue des Maladies Respiratoires with 5, bioRxiv (Cold Spring Harbor Laboratory) with 4, Nature Communications with 3, and Scientific Reports with 3 papers.

Recent papers authored or co-authored by Ryffel include:

  • Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade (2020, JCI Insight)
  • Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease (2020, Frontiers in Immunology)
  • STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS) (2022, Cell Death and Disease)
  • The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin (2020, Nature Immunology)
  • Inhibition of the NLRP3 inflammasome prevents ovarian aging (2021, Science Advances)

Frequent collaborators in research include Valérie Quesniaux, Dieudonnée Togbe, Isabelle Couillin, Marc Le Bert, and Florence Savigny.

Best Publications

  • Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

    Bertrand Routy;Bertrand Routy;Bertrand Routy;Lisa Derosa;Lisa Derosa;Lisa Derosa;Connie P. M. Duong;Connie P. M. Duong

  • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

    Sophie Viaud;Sophie Viaud;Fabiana Saccheri;Grégoire Mignot;Takahiro Yamazaki

  • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

    François Ghiringhelli;Lionel Apetoh;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Laetitia Aymeric;Laetitia Aymeric;Laetitia Aymeric

  • CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

    Bruno Lamas;Mathias L Richard;Valentin Leducq;Hang-Phuong Pham

  • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

    Fanny Chalmin;Sylvain Ladoire;Grégoire Mignot;Julie Vincent

  • Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors

    Eilon D. Kirson;Vladimír Dbalý;František Tovaryš;Josef Vymazal

  • Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

    Mélanie Bruchard;Grégoire Mignot;Grégoire Mignot;Valentin Derangère;Valentin Derangère;Fanny Chalmin;Fanny Chalmin

  • Interleukin-17 is a negative regulator of established allergic asthma

    Silvia Schnyder-Candrian;Dieudonnée Togbe;Isabelle Couillin;Isabelle Mercier

  • Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis

    Lutz Wollin;Isabelle Maillet;Valérie Quesniaux;Alexander Holweg

  • NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

    Aurélie Couturier-Maillard;Thomas Secher;Ateequr Rehman;Sylvain Normand

  • Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

    Federico Pietrocola;Federico Pietrocola;Jonathan Pol;Erika Vacchelli;Erika Vacchelli;Shuan Rao

  • IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

    Pamela Gasse;Caroline Mary;Isabelle Guenon;Nicolas Noulin

  • Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis Infection in Mice

    Brian Abel;Nathalie Thieblemont;Nathalie Thieblemont;Valerie J. F. Quesniaux;Najmeeyah Brown

  • Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.

    Pamela Gasse;Nicolas Riteau;Sabine Charron;Sandra Girre

  • Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis.

    Nicolas Riteau;Pamela Gasse;Louis Fauconnier;Aurélie Gombault

  • Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection.

    Michael B. Drennan;Delphine Nicolle;Valerie J.F. Quesniaux;Muazzam Jacobs

  • NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs

    Christophe Borg;Abdelali Jalil;Diego Laderach;Kouji Maruyama

  • IL-18 induces PD-1-dependent immunosuppression in cancer.

    Magali Terme;Evelyn Ullrich;Laetitia Aymeric;Kathrin Meinhardt

  • Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

    Gladys Ferrere;Maryam Tidjani Alou;Peng Liu;Anne-Gaëlle Goubet

  • Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

    Cathleen Holze;Chloé Michaudel;Claire Mackowiak;Darya A. Haas

  • Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.

    Cecile M. Fremond;Vladimir Yeremeev;Delphine M. Nicolle;Muazzam Jacobs

  • Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils: Protective and Deleterious Effects

    Sergei I. Grivennikov;Alexei V. Tumanov;Alexei V. Tumanov;Dmitry J. Liepinsh;Andrei A. Kruglov

Frequent Co-Authors

Valérie F. J. Quesniaux
Valérie F. J. Quesniaux University of Orléans
Song Guo Zheng
Song Guo Zheng Shanghai Jiao Tong University
Lionel Apetoh
Lionel Apetoh Indiana University
François Ghiringhelli
François Ghiringhelli Centre Georges François Leclerc
Shizuo Akira
Shizuo Akira Osaka University
Sergei A. Nedospasov
Sergei A. Nedospasov Lomonosov Moscow State University
Mathias Chamaillard
Mathias Chamaillard University of Lille
David D. Brand
David D. Brand University of Tennessee Health Science Center
Fernando Q. Cunha
Fernando Q. Cunha Universidade de São Paulo
Laurence Zitvogel
Laurence Zitvogel University of Paris-Saclay

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