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Orlando D. Schärer

Orlando D. Schärer

D-Index & Metrics

Genetics

D-Index
53
Citations
12717
World Ranking
3719
National Ranking
10

Overview

Orlando D. Schärer is affiliated with the Institute for Basic Science in South Korea and has a significant body of work primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their research focuses extensively on Molecular Biology, with additional contributions in Cancer Research, Genetics, Oncology, and Pathology and Forensic Medicine.

The scientist's main research topics cover several aspects of genetic and cellular function, including:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • DNA and Nucleic Acid Chemistry
  • Carcinogens and Genotoxicity Assessment
  • RNA Research and Splicing

Recent publications reflect a focus on molecular processes related to DNA repair and replication. Notable papers include:

  • "Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair," published in 2020 in DNA Repair
  • "Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex," 2020, Nucleic Acids Research
  • "SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks," 2020, Nature Communications
  • "Active DNA damage eviction by HLTF stimulates nucleotide excision repair," 2022, Molecular Cell
  • "Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes," 2021, Cellular and Molecular Life Sciences

The scientist frequently publishes in a variety of journals, with a pattern of repeated work in specific venues. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • NAR Cancer
  • DNA Repair
  • Nature Communications

Collaboration is an essential element of their research, with frequent co-authors such as Jung-Eun Yeo, Areetha D'Souza, Martijn S. Luijsterburg, Kook Son, and Hyun-Suk Kim. Each of these collaborators has contributed to multiple projects alongside Orlando D. Schärer, indicating ongoing research partnerships.

Best Publications

  • Nucleotide Excision Repair in Eukaryotes

    Orlando D. Schärer

  • Molecular mechanisms of mammalian global genome nucleotide excision repair.

    Ludovic C. J. Gillet;Orlando D. Schärer

  • Mechanism of replication-coupled DNA interstrand crosslink repair.

    Markus Räschle;Puck Knipscheer;Milica Enoiu;Todor Angelov

  • Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

    Huw M. Nash;Steven D. Bruner;Orlando D. Schärer;Tomohiko Kawate

  • The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

    Puck Knipscheer;Markus Räschle;Agata Smogorzewska;Agata Smogorzewska;Milica Enoiu

  • Chemistry and biology of DNA repair.

    Orlando D. Schärer

  • Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

    Yu V. Fu;Hasan Yardimci;David T. Long

  • Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.

    Massimo Bogliolo;Beatrice Schuster;Chantal Stoepker;Burak Derkunt

  • Recent progress in the biology, chemistry and structural biology of DNA glycosylases.

    Orlando D. Schärer;Josef Jiricny

  • Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision

    Albert Y. Lau;Orlando D. Schärer;Leona Samson;Gregory L. Verdine

  • Coordination of dual incision and repair synthesis in human nucleotide excision repair

    Lidija Staresincic;Adebanke F. Fagbemi;Jacqueline H. Enzlin;Audrey M. Gourdin

  • Structural Basis for the Excision Repair of Alkylation-Damaged DNA

    Jörg Labahn;Orlando D. Schärer;Alexander Long;Khosro Ezaz-Nikpay

  • Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

    Cheryl Clauson;Orlando D. Schärer;Laura Niedernhofer

  • DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses.

    Orlando D. Schärer

  • The active site of the DNA repair endonuclease XPF–ERCC1 forms a highly conserved nuclease motif

    Jacqueline H. Enzlin;Orlando D. Schärer

  • Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors.

    Angels Tapias;Jerome Auriol;Diane Forget;Jacqueline H. Enzlin

  • Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

    Oleg V. Tsodikov;Dmitri N Ivanov;Barbara Orelli;Lidija Staresincic

  • Single-molecule manipulation of double-stranded DNA using optical tweezers: Interaction studies of DNA with RecA and YOYO-1

    Martin L. Bennink;Orlando D. Schärer;Roland Kanaar;Kumiko Sakata‐Sogawa

  • Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

    Milica Enoiu;Josef Jiricny;Orlando D. Schärer

  • Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair (DOI:10.1016/j.cell.2008.08.030)

    Markus Räschle;Puck Knipscheer;Milica Enoiu;Todor Angelov

Frequent Co-Authors

Gregory L. Verdine
Gregory L. Verdine Harvard University
Josef Jiricny
Josef Jiricny University of Zurich
Tom Ellenberger
Tom Ellenberger Washington University in St. Louis
Johannes C. Walter
Johannes C. Walter Harvard University
Laura J. Niedernhofer
Laura J. Niedernhofer University of Minnesota
Olga I. Lavrik
Olga I. Lavrik Russian Academy of Sciences
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill
Agata Smogorzewska
Agata Smogorzewska Rockefeller University
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam

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