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Chemistry

D-Index
69
Citations
17477
World Ranking
6177
National Ranking
1881

Biology and Biochemistry

D-Index
75
Citations
19046
World Ranking
5348
National Ranking
2535

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

L. Mario Amzel is affiliated with Johns Hopkins University School of Medicine in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with additional work related to Medicine. Within these fields, their studies focus on subfields such as Molecular Biology, Endocrinology, Diabetes and Metabolism, Organic Chemistry, Genetics, and Spectroscopy.

The main topics addressed in their research include:

  • Thyroid Disorders and Treatments
  • RNA modifications and cancer
  • Ion channel regulation and function
  • Amino Acid Enzymes and Metabolism
  • Epigenetics and DNA Methylation
  • PI3K/AKT/mTOR signaling in cancer
  • Chemical Analysis and Environmental Impact

Amzel has published frequently in several scientific venues. Notable venues where they have contributed multiple publications include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Crystallographica Section A Foundations and Advances
  • Nature Structural & Molecular Biology
  • Structure
  • Nature

Significant recent papers authored or co-authored by Amzel cover a range of molecular and structural biology topics. These include:

  • Structural insights into the mechanism of the sodium/iodide symporter, 2022, Nature
  • Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate, 2020, Nature Structural & Molecular Biology
  • Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs, 2020, Molecules
  • Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation, 2020, The Journal of General Physiology
  • Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid, 2020, Scientific Reports

Their frequent collaborators include:

  • Sandra B. Gabelli
  • Mayukh Chakrabarti
  • Nancy Carrasco
  • Sweta Maheshwari
  • Jesse B. Yoder

Among their recognitions, Amzel was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • Three-Dimensional Structure of Immunoglobulins

    L M Amzel;R J Poljak

  • Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

    Asif K. Mustafa;Gautam Sikka;Sadia K. Gazi;Jochen Steppan

  • The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

    Chuan Hsiang Huang;Chuan Hsiang Huang;Diana Mandelker;Diana Mandelker;Oleg Schmidt-Kittler;Oleg Schmidt-Kittler;Yardena Samuels;Yardena Samuels

  • Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

    R. J. Poljak;L. M. Amzel;H. P. Avey;B. L. Chen

  • New insights into copper monooxygenases and peptide amidation: structure, mechanism and function.

    S. T. Prigge;R. E. Mains;B. A. Eipper;L. M. Amzel

  • The Three-Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase

    Unknown

  • Dioxygen Binds End-On to Mononuclear Copper in a Precatalytic Enzyme Complex

    Sean T. Prigge;Betty A. Eipper;Richard E. Mains;L. Mario Amzel

  • The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.

    Rongbao Li;M. A. Bianchet;P. Talalay;L. M. Amzel

  • Amidation of Bioactive Peptides: The Structure of Peptidylglycine α-Hydroxylating Monooxygenase

    Sean T. Prigge;Aparna S. Kolhekar;Betty A. Eipper;Richard E. Mains

  • The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.

    L. M. Amzel;R. J. Poljak;F. Saul;J. M. Varga

  • The magnitude of the backbone conformational entropy change in protein folding.

    J. Alejandro D'Aquino;Javier Gómez;Vincent J. Hilser;Kon Ho Lee;Kon Ho Lee

  • Structures and Mechanisms of Nudix Hydrolases

    A.S. Mildvan;Z. Xia;H.F. Azurmendi;V. Saraswat

  • Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

    F A Saul;L M Amzel;R J Poljak

  • A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

    D Mandelker;S.B Gabelli;O Schmidt-Kittler;J Zhu

  • PROTON ATPASES: STRUCTURE AND MECHANISM

    L M Amzel;P L Pedersen

  • THE 2.8-A STRUCTURE OF RAT LIVER F1-ATPASE : CONFIGURATION OF A CRITICAL INTERMEDIATE IN ATP SYNTHESIS/HYDROLYSIS

    Bianchet Ma;Hullihen J;Pedersen Pl;Amzel Lm

  • The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution

    R. J. Poljak;L. M. Amzel;B. L. Chen;R. P. Phizackerley

  • Estimation of changes in side chain configurational entropy in binding and folding: General methods and application to helix formation

    Kon Ho Lee;Dong Xie;Ernesto Freire;L. Mario Amzel

  • The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications

    Silvia Ravera;Andrea Reyna-Neyra;Giuseppe Ferrandino;L. Mario Amzel

  • ATP synthases. Structure, reaction center, mechanism, and regulation of one of nature's most unique machines.

    P L Pedersen;L M Amzel

  • Compensating enthalpic and entropic changes hinder binding affinity optimization.

    Virginie Lafont;Anthony A. Armstrong;Hiroyasu Ohtaka;Yoshiaki Kiso

  • Entropy in biological binding processes: estimation of translational entropy loss

    Kenneth P. Murphy;Dong Xie;Kelly S. Thompson;L. Mario Amzel

Frequent Co-Authors

Ernesto Freire
Ernesto Freire Johns Hopkins University
Peter L. Pedersen
Peter L. Pedersen Johns Hopkins University
Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Philip A. Cole
Philip A. Cole Brigham and Women's Hospital
Gerardo R. Vasta
Gerardo R. Vasta University of Maryland, Baltimore
Richard E. Mains
Richard E. Mains University of Connecticut Health Center
Betty A. Eipper
Betty A. Eipper University of Connecticut Health Center
Albert S. Mildvan
Albert S. Mildvan Johns Hopkins University
Yoshiaki Kiso
Yoshiaki Kiso Nagahama Institute of Bio-Science and Technology
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine

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