World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
103
Citations
31244
World Ranking
1131
National Ranking
449

Overview

Ernesto Freire is affiliated with Johns Hopkins University in the United States. Their research spans several interconnected fields, primarily focusing on biochemistry, genetics, molecular biology, medicine, and chemistry. Subfields of study in their work include molecular biology, radiology, nuclear medicine and imaging, physical and theoretical chemistry, cell biology, and biomedical engineering.

The core scientific topics addressed by Freire revolve around monoclonal and polyclonal antibodies research, protein purification and stability, thermodynamics and calorimetric analyses, glycosylation and glycoproteins research, ion channel regulation and function, cellular transport and secretion, and protein structure and dynamics.

Freire has contributed to scientific literature through several recent publications. These include:

  • Extrapolating Differential Scanning Calorimetry Data for Monoclonal Antibodies to Low Temperatures, 2023, SSRN Electronic Journal
  • Extrapolating differential scanning calorimetry data for monoclonal antibodies to low temperatures, 2024, Analytical Biochemistry
  • Reversibility and irreversibility in the temperature denaturation of monoclonal antibodies, 2021, Analytical Biochemistry
  • Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms, 2022, Journal of Biological Chemistry
  • Binding Thermodynamics to Intrinsically Disordered Protein Domains, 2020, Methods in molecular biology

Freire's frequent co-authors include Arne Schön, Young Do Kwon, Michael F. Bender, S. Lakshmi, and Vanina Alzogaray. These collaborations are reflected across multiple publications in venues such as Analytical Biochemistry, Journal of Biological Chemistry, Methods in molecular biology, and SSRN Electronic Journal.

The publication venues where Freire's work appears most often are:

  • Analytical Biochemistry
  • Journal of Biological Chemistry
  • Methods in molecular biology
  • SSRN Electronic Journal

Freire's body of research emphasizes the application of thermodynamic and calorimetric techniques to the study of antibodies and protein domains. Their investigations extend into the development of nanobodies targeting specific ion channel isoforms and the characterization of protein stability and structure under various conditions.

Best Publications

  • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

    Peter D. Kwong;Peter D. Kwong;Michael L. Doyle;Michael L. Doyle;David J. Casper;Claudia Cicala

  • Direct measurement of protein binding energetics by isothermal titration calorimetry

    Stephanie Leavitt;Ernesto Freire

  • Thermodynamics of structural stability and cooperative folding behavior in proteins.

    Kenneth P. Murphy;Ernesto Freire

  • Isothermal titration calorimetry

    Ernesto Freire;Obdulio L. Mayorga;Martin Straume

  • Do enthalpy and entropy distinguish first in class from best in class

    Ernesto Freire

  • The heat capacity of proteins.

    Javier Gómez;Vincent J. Hilser;Dong Xie;Ernesto Freire

  • Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

    Qingguo Xu;Laura M. Ensign;Laura M. Ensign;Nicholas J. Boylan;Arne Schön

  • Statistical mechanical deconvolution of thermal transitions in macromolecules. I. Theory and application to homogeneous systems

    Ernesto Freire;Rodney L. Biltonen

  • Adding calorimetric data to decision making in lead discovery: a hot tip

    John E. Ladbury;Gerhard Klebe;Ernesto Freire

  • Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

    Young Do Kwon;Marie Pancera;Priyamvada Acharya;Ivelin S. Georgiev

  • Isothermal titration calorimetry to determine association constants for high-affinity ligands

    Adrian Velazquez-Campoy;Ernesto Freire

  • The magnitude of the backbone conformational entropy change in protein folding.

    J. Alejandro D'Aquino;Javier Gómez;Vincent J. Hilser;Kon Ho Lee;Kon Ho Lee

  • Forces and factors that contribute to the structural stability of membrane proteins.

    Tuomas Haltia;Ernesto I Freire

  • Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

    Zhihai Si;Navid Madani;Jason M. Cox;Jason J. Chruma

  • Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

    Vincent J. Hilser;Ernesto Freire

  • Calorimetrically Determined Dynamics of Complex Unfolding Transitions in Proteins

    E Freire;W W van Osdol;O L Mayorga;J M Sanchez-Ruiz

  • Thermodynamic Mapping of the Inhibitor Site of the Aspartic Protease Endothiapepsin

    Javier Gómez;Ernesto Freire

  • Differential Scanning Calorimetry

    Ernesto Freire

  • Isothermal Titration Calorimetry

    Adrián Velázquez-Campoy;Hiroyasu Ohtaka;Azin Nezami;Salman Muzammil

  • A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

    Neville K. Kisalu;Azza H. Idris;Connor Weidle;Yevel Flores-Garcia

  • Estimation of changes in side chain configurational entropy in binding and folding: General methods and application to helix formation

    Kon Ho Lee;Dong Xie;Ernesto Freire;L. Mario Amzel

  • ITC in the post-genomic era...? Priceless.

    Adrián Velázquez Campoy;Ernesto Freire

Frequent Co-Authors

Joseph Sodroski
Joseph Sodroski Harvard Medical School
Yoshiaki Kiso
Yoshiaki Kiso Nagahama Institute of Bio-Science and Technology
Amos B. Smith
Amos B. Smith University of Pennsylvania
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
Rodney L. Biltonen
Rodney L. Biltonen University of Virginia
L. Mario Amzel
L. Mario Amzel Johns Hopkins University School of Medicine
Vincent J. Hilser
Vincent J. Hilser Johns Hopkins University
Marie Pancera
Marie Pancera Fred Hutchinson Cancer Research Center
Irwin M. Chaiken
Irwin M. Chaiken Drexel University
Gwo-Yu Chuang
Gwo-Yu Chuang Moderna Therapeutics (United States)

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry, exploring related fields such as forensic science and criminal justice can open diverse career opportunities. Many professionals in forensic science apply chemical principles to analyze evidence, making interdisciplinary knowledge highly valuable. Those looking to specialize further might consider an online forensic psychology masters program, which combines psychology with forensic methodologies for a unique career path.

Understanding the broad range of careers in forensic science can help students align their chemistry knowledge with practical job roles such as toxicology, crime lab analysis, or forensic chemistry. Additionally, many find that earning a degree in criminal justice supports their career progression. Exploring the criminal justice degree tuition options allows students to plan their education finances effectively while pursuing this field.

For those starting out, some of the best online associate degree programs in criminal justice offer an excellent foundation before advancing to specialized chemistry or forensic degrees. These pathways collectively build a strong skillset to thrive at the intersection of science and law enforcement.

Best Scientists Citing Ernesto Freire

Trending Scientists

Recently Published Articles