World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
103
Citations
31244
World Ranking
1131
National Ranking
448

Ernesto Freire publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Ernesto Freire sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 294 publications — 62nd percentile

62% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Ernesto Freire D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Ernesto Freire sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 103 D-Index — 94th percentile

94% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Ernesto Freire is affiliated with Johns Hopkins University in the United States. Their research spans several interconnected fields, primarily focusing on biochemistry, genetics, molecular biology, medicine, and chemistry. Subfields of study in their work include molecular biology, radiology, nuclear medicine and imaging, physical and theoretical chemistry, cell biology, and biomedical engineering.

The core scientific topics addressed by Freire revolve around monoclonal and polyclonal antibodies research, protein purification and stability, thermodynamics and calorimetric analyses, glycosylation and glycoproteins research, ion channel regulation and function, cellular transport and secretion, and protein structure and dynamics.

Freire has contributed to scientific literature through several recent publications. These include:

  • Extrapolating Differential Scanning Calorimetry Data for Monoclonal Antibodies to Low Temperatures, 2023, SSRN Electronic Journal
  • Extrapolating differential scanning calorimetry data for monoclonal antibodies to low temperatures, 2024, Analytical Biochemistry
  • Reversibility and irreversibility in the temperature denaturation of monoclonal antibodies, 2021, Analytical Biochemistry
  • Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms, 2022, Journal of Biological Chemistry
  • Binding Thermodynamics to Intrinsically Disordered Protein Domains, 2020, Methods in molecular biology

Freire's frequent co-authors include Arne Schön, Young Do Kwon, Michael F. Bender, S. Lakshmi, and Vanina Alzogaray. These collaborations are reflected across multiple publications in venues such as Analytical Biochemistry, Journal of Biological Chemistry, Methods in molecular biology, and SSRN Electronic Journal.

The publication venues where Freire's work appears most often are:

  • Analytical Biochemistry
  • Journal of Biological Chemistry
  • Methods in molecular biology
  • SSRN Electronic Journal

Freire's body of research emphasizes the application of thermodynamic and calorimetric techniques to the study of antibodies and protein domains. Their investigations extend into the development of nanobodies targeting specific ion channel isoforms and the characterization of protein stability and structure under various conditions.

Best Publications

  • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

    Peter D. Kwong;Peter D. Kwong;Michael L. Doyle;Michael L. Doyle;David J. Casper;Claudia Cicala

  • Direct measurement of protein binding energetics by isothermal titration calorimetry

    Stephanie Leavitt;Ernesto Freire

  • Thermodynamics of structural stability and cooperative folding behavior in proteins.

    Kenneth P. Murphy;Ernesto Freire

  • Isothermal titration calorimetry

    Ernesto Freire;Obdulio L. Mayorga;Martin Straume

  • Do enthalpy and entropy distinguish first in class from best in class

    Ernesto Freire

  • The heat capacity of proteins.

    Javier Gómez;Vincent J. Hilser;Dong Xie;Ernesto Freire

  • Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

    Qingguo Xu;Laura M. Ensign;Laura M. Ensign;Nicholas J. Boylan;Arne Schön

  • Statistical mechanical deconvolution of thermal transitions in macromolecules. I. Theory and application to homogeneous systems

    Ernesto Freire;Rodney L. Biltonen

  • Adding calorimetric data to decision making in lead discovery: a hot tip

    John E. Ladbury;Gerhard Klebe;Ernesto Freire

  • Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

    Young Do Kwon;Marie Pancera;Priyamvada Acharya;Ivelin S. Georgiev

  • Isothermal titration calorimetry to determine association constants for high-affinity ligands

    Adrian Velazquez-Campoy;Ernesto Freire

  • The magnitude of the backbone conformational entropy change in protein folding.

    J. Alejandro D'Aquino;Javier Gómez;Vincent J. Hilser;Kon Ho Lee;Kon Ho Lee

  • Forces and factors that contribute to the structural stability of membrane proteins.

    Tuomas Haltia;Ernesto I Freire

  • Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

    Zhihai Si;Navid Madani;Jason M. Cox;Jason J. Chruma

  • Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

    Vincent J. Hilser;Ernesto Freire

  • Calorimetrically Determined Dynamics of Complex Unfolding Transitions in Proteins

    E Freire;W W van Osdol;O L Mayorga;J M Sanchez-Ruiz

  • Thermodynamic Mapping of the Inhibitor Site of the Aspartic Protease Endothiapepsin

    Javier Gómez;Ernesto Freire

  • Differential Scanning Calorimetry

    Ernesto Freire

  • Isothermal Titration Calorimetry

    Adrián Velázquez-Campoy;Hiroyasu Ohtaka;Azin Nezami;Salman Muzammil

  • A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

    Neville K. Kisalu;Azza H. Idris;Connor Weidle;Yevel Flores-Garcia

  • Estimation of changes in side chain configurational entropy in binding and folding: General methods and application to helix formation

    Kon Ho Lee;Dong Xie;Ernesto Freire;L. Mario Amzel

  • ITC in the post-genomic era...? Priceless.

    Adrián Velázquez Campoy;Ernesto Freire

Frequent Co-Authors

Joseph Sodroski
Joseph Sodroski Harvard Medical School
Yoshiaki Kiso
Yoshiaki Kiso Nagahama Institute of Bio-Science and Technology
Amos B. Smith
Amos B. Smith University of Pennsylvania
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
Rodney L. Biltonen
Rodney L. Biltonen University of Virginia
L. Mario Amzel
L. Mario Amzel Johns Hopkins University School of Medicine
Vincent J. Hilser
Vincent J. Hilser Johns Hopkins University
Marie Pancera
Marie Pancera Fred Hutchinson Cancer Research Center
Irwin M. Chaiken
Irwin M. Chaiken Drexel University
Gwo-Yu Chuang
Gwo-Yu Chuang Moderna Therapeutics (United States)

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