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Irwin M. Chaiken

Irwin M. Chaiken

D-Index & Metrics

Chemistry

D-Index
53
Citations
10849
World Ranking
13012
National Ranking
3437

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors

Overview

Irwin M. Chaiken is affiliated with Drexel University in the United States. Their research primarily focuses on Medicine and Immunology and Microbiology, with significant contributions in related subfields such as Infectious Diseases, Virology, Molecular Biology, Immunology, and Radiology, Nuclear Medicine and Imaging.

The main topics of their work include HIV Research and Treatment, HIV/AIDS drug development and treatment, SARS-CoV-2 and COVID-19 Research, RNA Interference and Gene Delivery, Monoclonal and Polyclonal Antibodies Research, COVID-19 Clinical Research Studies, and Immune Cell Function and Interaction.

Irwin M. Chaiken has published extensively in several venues, with frequent publications in:

  • Frontiers in Immunology
  • Biochemistry
  • ACS Chemical Biology
  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)

Some selected recent papers include:

  • The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic (2021), Frontiers in Immunology
  • The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site (2020), mBio
  • Injectable Granular Hydrogels Enable Avidity-Controlled Biotherapeutic Delivery (2024), ACS Biomaterials Science & Engineering
  • Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors (2020), Biochemistry
  • Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein (2023), Biochemistry

Frequent collaborators of Irwin M. Chaiken include:

  • Gabriela Canziani
  • Cameron F. Abrams
  • Charles G. Ang
  • Adel A. Rashad
  • Amos B. Smith

In 2020, Irwin M. Chaiken was recognized as a Fellow of the National Academy of Inventors.

Best Publications

  • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

    Peter D. Kwong;Peter D. Kwong;Michael L. Doyle;Michael L. Doyle;David J. Casper;Claudia Cicala

  • Interpreting complex binding kinetics from optical biosensors: a comparison of analysis by linearization, the integrated rate equation, and numerical integration.

    T.A. Morton;D.G. Myszka;I.M. Chaiken

  • Nature of the charged-group effect on the stability of the C-peptide helix.

    Kevin R. Shoemaker;Peter S. Kim;David N. Brems;Susan Marqusee

  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

    Trevor L. Hoffman;Celia C. LaBranche;Wentao Zhang;Gabriella Canziani

  • Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor.

    David G. Myszka;Thomas A. Morton;Michael L. Doyle;Irwin M. Chaiken

  • Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

    Zhihai Si;Navid Madani;Jason M. Cox;Jason J. Chruma

  • Analysis of macromolecular interactions using immobilized ligands.

    Irwin Chaiken;Sergio Rosé;Robert Karlsson

  • Semisynthetic peptides and proteins

    Irwin M. Chaiken

  • Click Chemistry in Peptide-Based Drug Design

    Huiyuan Li;Rachna Aneja;Irwin Chaiken

  • Controlled formation of model homo- and heterodimer coiled coil polypeptides

    Thomas J. Graddis;David G. Myszka;Irwin M. Chaiken

  • Binding Interactions of Human Interleukin 5 with Its Receptor α Subunit: LARGE SCALE PRODUCTION, STRUCTURAL, AND FUNCTIONAL STUDIES OF DROSOPHILA-EXPRESSED RECOMBINANT PROTEINS (∗)

    Kyung Johanson;Edward Appelbaum;Michael Doyle;Preston Hensley

  • Quantitative affinity chromatography. Determination of binding constants by elution with competitive inhibitors.

    Ben M. Dunn;Irwin M. Chaiken

  • Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders

    Robert S. Ames;Edward Robert Appelbaum;Irwin M. Chaiken;Richard M. Cook

  • Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic.

    Wentao Zhang;Gabriela Canziani;Carmela Plugariu;Richard Wyatt

  • Anti-sense peptide recognition of sense peptides: direct quantitative characterization with the ribonuclease S-peptide system using analytical high-performance affinity chromatography.

    Yechiel Shai;Michael Flashner;Irwin M. Chaiken

  • Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist

    Joel R. Courter;Navid Madani;Joseph Sodroski;Joseph Sodroski;Arne Schön

  • Evaluation of quantitative affinity chromatography by comparison with kinetic and equilibrium dialysis methods for the analysis of nucleotide binding to staphylococcal nuclease.

    Ben M. Dunn;Irwin M. Chaiken

  • Current trends in molecular recognition and bioseparation

    Chris Jones;Arun Patel;Skip Griffin;John Martin

  • Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425.

    Vishal Kamat;Joshua M. Donaldson;Csaba Kari;Marlene R.D. Quadros

  • Design and characterization of an intramolecular antiparallel coiled coil peptide.

    David G. Myszka;Irwin M. Chaiken

  • Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.

    Hao Wu;David G. Myszka;Susan W. Tendian;Christie G. Brouillette

  • Peptides 1982—Proceedings of the 17th European Peptide Symposium: Edited by K. Bláha and P. Malon̆, de Gruyter, Berlin, 1983. 846 pp. $134.00

    Irwin M. Chaiken

Frequent Co-Authors

Joseph Sodroski
Joseph Sodroski Harvard Medical School
David G. Myszka
David G. Myszka University of Utah
Amos B. Smith
Amos B. Smith University of Pennsylvania
Ernesto Freire
Ernesto Freire Johns Hopkins University
Thomas A. Morton
Thomas A. Morton University of Copenhagen
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Richard J. Cook
Richard J. Cook University of Waterloo
Richard T. Wyatt
Richard T. Wyatt Scripps Research Institute
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
Douglas B. Cines
Douglas B. Cines University of Pennsylvania

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