World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
100
Citations
30378
World Ranking
8358
National Ranking
4318

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

James A. Hoxie is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on topics related to medicine, immunology, and microbiology, with a strong emphasis on infectious diseases, immunology, virology, epidemiology, and neurology.

The scientist's body of work includes key topics such as HIV research and treatment, SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, immune cell function and interaction, T-cell and B-cell immunology, and the long-term effects of COVID-19. These topics intersect studies on HIV/AIDS drug development and treatment.

They have contributed to several recent papers, including:

  • Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo, 2020, Nature Medicine
  • The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease, 2021, PLoS Pathogens
  • Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4, 2022, PLoS Pathogens
  • HIV-1-Infected CD4+ T Cells Present MHC Class II-Restricted Epitope via Endogenous Processing, 2022, The Journal of Immunology
  • A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection, 2022, PLoS Pathogens

The frequent coauthors collaborating with James A. Hoxie include:

  • Nicholas J. Maness
  • Lara Doyle-Meyers
  • Robert V. Blair
  • Pyone P. Aye
  • Faith Schiro

James A. Hoxie's work has been published in notable venues such as:

  • PLoS Pathogens
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine
  • The Journal of Immunology
  • PLoS ONE

Their research spans across 19 publications in Medicine and 12 in Immunology and Microbiology. The specific subfields covered include 11 publications in infectious diseases, 6 in immunology, and 6 in virology, among others.

James A. Hoxie has received recognition as a member of the Association of American Physicians, an award that reflects their standing in the medical research community.

Best Publications

  • The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

    Conrad C. Bleul;Lijun Wu;James A. Hoxie;Timothy A. Springer

  • Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

    S J Shattil;J A Hoxie;M Cunningham;L F Brass

  • Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

    Sanford J. Shattil;Michael Cunningham;James A. Hoxie

  • Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

    Marina Molino;Elliot S. Barnathan;Robert Numerof;Jim Clark

  • CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

    Michael J Endres;Paul R Clapham;Mark Marsh;Ména Ahuja

  • Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

    Katharine J Bar;Michael C Sneller;Linda J Harrison;J Shawn Justement

  • Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4

    Joseph Hesselgesser;Dennis Taub;Padmavathi Baskar;Michael Greenberg

  • Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.

    James A. Hoxie;James D. Alpers;Jerome L. Rackowski;Kay Huebner

  • The chemokine SDF‐1, stromal cell‐derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4

    Massimo D'Apuzzo;Antonius Rolink;Marcel Loetscher;James A. Hoxie

  • Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

    Elena Chertova;Julian W. Bess;Bruce J. Crise;Raymond C. Sowder

  • Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

    Joel S. Bennett;James A. Hoxie;Susan F. Leitman;Gaston Vilaire

  • CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.

    Joseph Hesselgesser;Meredith Halks-Miller;Virginia DelVecchio;Stephen C. Peiper

  • Antigenic conservation and immunogenicity of the HIV coreceptor binding site

    Julie M. Decker;Frederic Bibollet-Ruche;Xiping Wei;Shuyi Wang

  • Internalization and recycling of activated thrombin receptors

    James A. Hoxie;Menaka Ahuja;Elizabeth Belmonte;Shelly Pizarro

  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

    Trevor L. Hoffman;Celia C. LaBranche;Wentao Zhang;Gabriella Canziani

  • CD4-independent infection of human neural cells by human immunodeficiency virus type 1.

    J M Harouse;C Kunsch;H T Hartle;M A Laughlin

  • A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.

    R Taub;R J Gould;V M Garsky;T M Ciccarone

  • Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation

    Tsuneyoshi Hamada;Robert Möhle;Joseph Hesselgesser;James Hoxie

  • HIV vaccine research: the way forward.

    Anthony S. Fauci;Margaret I. Johnston;Carl W. Dieffenbach;Dennis R. Burton

  • An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum

    Guido Ferrari;Justin Pollara;Daniel Kozink;Tiara Harms

Frequent Co-Authors

Robert W. Doms
Robert W. Doms Children's Hospital of Philadelphia
Lawrence F. Brass
Lawrence F. Brass University of Pennsylvania
Mark Marsh
Mark Marsh University College London
Celia C. LaBranche
Celia C. LaBranche Duke University
Robert H. Vonderheide
Robert H. Vonderheide University of Pennsylvania
David L. Porter
David L. Porter University of Pennsylvania
George M. Shaw
George M. Shaw University of Pennsylvania
Dennis L. Kolson
Dennis L. Kolson University of Pennsylvania
David C. Montefiori
David C. Montefiori Duke University
Beatrice H. Hahn
Beatrice H. Hahn University of Pennsylvania

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