World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
43
Citations
8609
World Ranking
19373
National Ranking
7907

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Vincent J. Hilser is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on Biochemistry, Genetics and Molecular Biology, with a notable emphasis on Molecular Biology, Materials Chemistry, Spectroscopy, Biophysics, and Atomic and Molecular Physics, and Optics.

The scientist's work addresses several main topics including Protein Structure and Dynamics, RNA and protein synthesis mechanisms, Enzyme Structure and Function, Heat shock proteins research, RNA Research and Splicing, Nuclear Structure and Function, and Receptor Mechanisms and Signaling.

Vincent J. Hilser has published extensively in the following venues:

  • Biophysical Journal
  • Protein Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences

Some recent papers authored or co-authored by Hilser include:

  • Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer (2020) - Journal of Biological Chemistry
  • Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome (2020) - Proceedings of the National Academy of Sciences
  • Phylogenetic convergence of phase separation and mitotic function in the disordered protein BuGZ (2022) - Protein Science
  • Tumor Susceptibility Gene 101 Regulates the Glucocorticoid Receptor through Disorder-Mediated Allostery (2021) - Biochemistry
  • Conserved allosteric ensembles in disordered proteins using TROSY/anti-TROSY R2-filtered spectroscopy (2021) - Biophysical Journal

Frequent collaborators in Hilser's research include James O. Wrabl, Sarah J. Brantley, Jordan T. White, Ammon E. Posey, and Mehran Bagheri. These partnerships have contributed to a substantial body of work available in their primary and subfields.

Hilser's contributions have been recognized with the award of Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • The ensemble nature of allostery

    Hesam N. Motlagh;James O. Wrabl;Jing Li;Vincent J. Hilser

  • The heat capacity of proteins.

    Javier Gómez;Vincent J. Hilser;Dong Xie;Ernesto Freire

  • Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

    Vincent J. Hilser;E. Brad Thompson

  • Allostery in Its Many Disguises: From Theory to Applications

    Shoshana J. Wodak;Emanuele Paci;Nikolay V. Dokholyan;Nikolay V. Dokholyan;Igor N. Berezovsky

  • The magnitude of the backbone conformational entropy change in protein folding.

    J. Alejandro D'Aquino;Javier Gómez;Vincent J. Hilser;Kon Ho Lee;Kon Ho Lee

  • Structural and energetic basis of allostery.

    Vincent J. Hilser;James O. Wrabl;Hesam N. Motlagh

  • Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

    Vincent J. Hilser;Ernesto Freire

  • Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble

    Hong Pan;J. Ching Lee;Vincent J. Hilser

  • The structural distribution of cooperative interactions in proteins: Analysis of the native state ensemble

    Vincent J. Hilser;David Dowdy;Terrence G. Oas;Ernesto Freire

  • A statistical thermodynamic model of the protein ensemble.

    Vincent J. Hilser;Bertrand Garcia-Moreno E;Terrence G. Oas;Greg Kapp

  • Dynamic allostery can drive cold adaptation in enzymes

    Harry G. Saavedra;James O. Wrabl;Jeremy A. Anderson;Jing Li

  • Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins

    Steven T. Whitten;E Bertrand García-Moreno;Vincent J. Hilser

  • Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

    Travis P. Schrank;D. Wayne Bolen;Vincent J. Hilser

  • The enthalpy change in protein folding and binding: Refinement of parameters for structure‐based calculations

    Vincent J. Hilser;Javier Gómez;Ernesto Freire

  • Direct access to the cooperative substructure of proteins and the protein ensemble via cold denaturation.

    Charles R Babu;Vincent J Hilser;A Joshua Wand

  • An Ensemble View of Allostery

    Vincent J. Hilser

  • The role of protein conformational fluctuations in allostery, function, and evolution.

    James O. Wrabl;Jenny Gu;Tong Liu;Travis P. Schrank

  • Agonism/antagonism switching in allosteric ensembles

    Hesam N. Motlagh;Vincent J. Hilser

  • Coupled Motion in Proteins Revealed by Pressure Perturbation

    Yinan Fu;Vignesh Kasinath;Veronica R. Moorman;Nathaniel V. Nucci

  • Predicting the equilibrium protein folding pathway: structure-based analysis of staphylococcal nuclease.

    Vincent J. Hilser;Ernesto Freire

Frequent Co-Authors

Ernesto Freire
Ernesto Freire Johns Hopkins University
A. Joshua Wand
A. Joshua Wand University of Pennsylvania
Rebecca C. Wade
Rebecca C. Wade Heidelberg Institute for Theoretical Studies
Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Jean-Pierre Changeux
Jean-Pierre Changeux Institut Pasteur
Alexander N. Freiberg
Alexander N. Freiberg The University of Texas Medical Branch at Galveston
David W.C. Beasley
David W.C. Beasley The University of Texas Medical Branch at Galveston
Ruth Nussinov
Ruth Nussinov National Institutes of Health
Shoshana J. Wodak
Shoshana J. Wodak Vrije Universiteit Brussel
Tom McLeish
Tom McLeish University of York

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