World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
10112
World Ranking
17953
National Ranking
7349

Overview

John J. Mieyal is affiliated with Case Western Reserve University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in several subfields including molecular biology, biochemistry, immunology, and organic chemistry.

The scientist's work covers various main topics, such as:

  • Sulfur Compounds in Biology
  • Redox biology and oxidative stress
  • Glutathione Transferases and Polymorphisms
  • Phagocytosis and Immune Regulation
  • Synthesis and Characterization of Heterocyclic Compounds

John J. Mieyal has published research in different scientific venues, notably in:

  • Antioxidants
  • mBio

Among their recent papers are:

  • "Glutathione and Glutaredoxin-Key Players in Cellular Redox Homeostasis and Signaling," published in 2023 in Antioxidants
  • "Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300," published in 2021 in mBio

Their work has involved collaboration with multiple frequent coauthors including:

  • Yuh-Cherng Chai
  • David A. Davis
  • Haydar Bulut
  • Prabha Shrestha
  • Amulya Yaparla

This body of work contributes to understanding biochemical processes related to cellular redox homeostasis, immune regulation, and molecular mechanisms of enzyme activity modification. Throughout their career, the scientist has focused on detailed molecular interactions and the roles of specific sulfur-containing compounds in biology.

Best Publications

  • Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

    John J. Mieyal;John J. Mieyal;Molly M. Gallogly;Suparna Qanungo;Elizabeth A. Sabens;Elizabeth A. Sabens

  • Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress.

    Molly M Gallogly;John J Mieyal

  • Glutaredoxin: Role in Reversible Protein S-Glutathionylation and Regulation of Redox Signal Transduction and Protein Translocation

    Melissa D. Shelton;P. Boon Chock;John J. Mieyal

  • Reversible Glutathionylation Regulates Actin Polymerization in A431 Cells

    Jun Wang;Emily S. Boja;Wuhong Tan;Ephrem Tekle

  • Dysregulation of glutathione homeostasis in neurodegenerative diseases.

    William M. Johnson;Amy L. Wilson-Delfosse;John. J. Mieyal

  • Thioltransferase is a specific glutathionyl mixed disulfide oxidoreductase.

    Stephen A. Gravina;John J. Mieyal

  • Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis

    Carol A. Chrestensen;David W. Starke;John J. Mieyal

  • Mechanistic and Kinetic Details of Catalysis of Thiol-Disulfide Exchange by Glutaredoxins and Potential Mechanisms of Regulation

    Molly M. Gallogly;David W. Starke;John J. Mieyal;John J. Mieyal

  • Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction.

    David W. Starke;P. Boon Chock;John J. Mieyal

  • Thioltransferase (Glutaredoxin) Is Detected Within HIV-1 and Can Regulate the Activity of Glutathionylated HIV-1 Protease in Vitro

    David A. Davis;Fonda M. Newcomb;David W. Starke;David E. Ott

  • Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity.

    Yanwu Yang;Shu Chuan Jao;Sambasivarao Nanduri;David W. Starke

  • Glutathione Supplementation Potentiates Hypoxic Apoptosis by S-Glutathionylation of p65-NFκB *

    Suparna Qanungo;David W. Starke;Harish V. Pai;John J. Mieyal

  • Reversible Inactivation of α-Ketoglutarate Dehydrogenase in Response to Alterations in the Mitochondrial Glutathione Status†

    Amy C. Nulton-Persson;David W. Starke;John J. Mieyal;Luke I. Szweda

  • Posttranslational Modification of Cysteine in Redox Signaling and Oxidative Stress: Focus on S-Glutathionylation

    John J. Mieyal;P. Boon Chock

  • Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin

    Jun Wang;Ephrem Tekle;Hammou Oubrahim;John J. Mieyal

  • Protein-Thiol Oxidation and Cell Death: Regulatory Role of Glutaredoxins

    Erin M.G. Allen;John J. Mieyal

  • Thioltransferase (Glutaredoxin) Reactivates the DNA-binding Activity of Oxidation-inactivated Nuclear Factor I

    Smarajit Bandyopadhyay;David W. Starke;John J. Mieyal;Richard M. Gronostajski;Richard M. Gronostajski

  • pH profiles indicative of rate-limiting nucleophilic displacement in thioltransferase catalysis.

    Usha Srinivasan;Paul A. Mieyal;John J. Mieyal

  • Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases.

    Melissa D. Shelton;John J. Mieyal

  • Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles.

    Molly M. Gallogly;David W. Starke;Amanda K. Leonberg;Susan M. English Ospina

Frequent Co-Authors

Edward J. Lesnefsky
Edward J. Lesnefsky Virginia Commonwealth University
Timothy S. Kern
Timothy S. Kern University of California, Irvine
Xiongwei Zhu
Xiongwei Zhu Case Western Reserve University
Charles L. Hoppel
Charles L. Hoppel Case Western Reserve University
John J. Lemasters
John J. Lemasters Medical University of South Carolina
Vernon E. Anderson
Vernon E. Anderson Case Western Reserve University
Danyelle M. Townsend
Danyelle M. Townsend Medical University of South Carolina
Richard M. Gronostajski
Richard M. Gronostajski University at Buffalo, State University of New York
Marcin Golczak
Marcin Golczak Case Western Reserve University
Vijayalakshmi Ravindranath
Vijayalakshmi Ravindranath Indian Institute of Science

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