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Biology and Biochemistry

D-Index
103
Citations
35571
World Ranking
1324
National Ranking
774

Medicine

D-Index
103
Citations
35897
World Ranking
7411
National Ranking
3874

Overview

Charles L. Hoppel is affiliated with Case Western Reserve University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with a significant number of publications in these areas. Subfields of particular interest include Molecular Biology, Physiology, Clinical Biochemistry, Epidemiology, and Neurology.

The main topics addressed in their work encompass Mitochondrial Function and Pathology, Adipose Tissue and Metabolism, Metabolism and Genetic Disorders, ATP Synthase and ATPases Research, Metabolomics and Mass Spectrometry Studies, Muscle Metabolism and Nutrition, and Nutrition and Health in Aging.

Frequent co-authors who have collaborated extensively with Hoppel include Christopher L. Axelrod, John P. Kirwan, Elizabeth R. M. Zunica, Gangarao Davuluri, and Wagner S. Dantas.

Charles L. Hoppel has published articles in a variety of scientific journals. Notable publication venues include the Journal of Cachexia Sarcopenia and Muscle, Scientific Reports, Diabetes, EMBO Molecular Medicine, and Metabolism.

  • "BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control" (2020) in EMBO Molecular Medicine
  • "Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans" (2021) in Metabolism
  • "Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control" (2022) in Journal of Cachexia Sarcopenia and Muscle
  • "Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass" (2021) in Scientific Reports
  • "Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women" (2021) in American Journal of Physiology-Endocrinology and Metabolism

Best Publications

  • Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III *

    Qun Chen;Qun Chen;Edwin J. Vazquez;Shadi Moghaddas;Charles L. Hoppel;Charles L. Hoppel

  • Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle.

    J W Palmer;B Tandler;C L Hoppel

  • Effect of high-dose ibuprofen in patients with cystic fibrosis.

    Michael W. Konstan;Pamela J. Byard;Charles L. Hoppel;Pamela B. Davis

  • Fatty acid import into mitochondria.

    Janos Kerner;Charles Hoppel

  • Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure.

    Edward J. Lesnefsky;Edward J. Lesnefsky;Shadi Moghaddas;Bernard Tandler;Janos Kerner

  • Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

    Sean H. Adams;Charles L. Hoppel;Kerry H. Lok;Ling Zhao

  • The Failing Heart Relies on Ketone Bodies as a Fuel

    Gregory Aubert;Ola J. Martin;Julie L. Horton;Ling Lai

  • Carnitine: a nutritional, biosynthetic, and functional perspective

    Alison Leah Steiber;Janos Kerner;Charles L. Hoppel;Charles L. Hoppel

  • Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

    Tatyana I. Gudz;Kou Yi Tserng;Kou Yi Tserng;Charles L. Hoppel

  • Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

    Oliver Fiehn;W. Timothy Garvey;John W. Newman;Kerry H. Lok

  • Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

    Mariana G. Rosca;Edwin J. Vazquez;Janos Kerner;William Parland

  • The role of carnitine in normal and altered fatty acid metabolism.

    Charles Hoppel

  • Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

    Qun Chen;Shadi Moghaddas;Charles L. Hoppel;Edward J. Lesnefsky

  • Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies

    Edward J. Lesnefsky;Edward J. Lesnefsky;Qun Chen;Bernard Tandler;Charles L. Hoppel

  • HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

    Weinan Du;Luchang Zhang;Adina Brett-Morris;Brittany Aguila

  • A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.

    Jaume Amengual;Glenn P. Lobo;Marcin Bernard Golczak;Hua Nan M Li

  • Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion

    Qun Chen;Amadou K. S. Camara;David F. Stowe;David F. Stowe;David F. Stowe;Charles L. Hoppel

  • Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

    Wenzhang Wang;Xinglong Wang;Hisashi Fujioka;Charles Hoppel

  • Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states.

    C Hoppel;J P DiMarco;B Tandler

  • Mitochondrial Metabolism in Aging Heart.

    Edward J. Lesnefsky;Qun Chen;Charles L. Hoppel

Frequent Co-Authors

Edward J. Lesnefsky
Edward J. Lesnefsky Virginia Commonwealth University
Bernard Tandler
Bernard Tandler Case Western Reserve University
Hisashi Fujioka
Hisashi Fujioka Case Western Reserve University
Henri Brunengraber
Henri Brunengraber Case Western Reserve University
W. Timothy Garvey
W. Timothy Garvey University of Alabama at Birmingham
John P. Kirwan
John P. Kirwan Pennington Biomedical Research Center
Stanton L. Gerson
Stanton L. Gerson Case Western Reserve University
Martin E. Young
Martin E. Young University of Alabama at Birmingham
Oliver Fiehn
Oliver Fiehn University of California, Davis
Mukesh K. Jain
Mukesh K. Jain Brown University

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