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Chemistry

D-Index
55
Citations
8134
World Ranking
12403
National Ranking
3303

Overview

Henri Brunengraber is affiliated with Case Western Reserve University in the United States. Their research spans primarily the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a particular focus on cancer biology, metabolism, and clinical applications.

The main areas of study for their work include:

  • Cancer Research
  • Oncology
  • Surgery
  • Physiology
  • Biomedical Engineering

Brunengraber's research topics cover:

  • Cancer, Hypoxia, and Metabolism
  • Pancreatic and Hepatic Oncology Research
  • Diet and Metabolism Studies
  • Epigenetics and DNA Methylation
  • Cardiac Ischemia and Reperfusion
  • Mechanical Circulatory Support Devices
  • Dialysis and Renal Disease Management

They have published extensively in several venues, with multiple papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Military Medicine
  • Nature Communications
  • Plastic & Reconstructive Surgery Global Open
  • Preprints.org

Among their recent papers are:

  • Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors (2022, Nature Cancer)
  • Increased glucose availability sensitizes pancreatic cancer to chemotherapy (2023, Nature Communications)
  • Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease (2022, American Journal of Kidney Diseases)
  • Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells (2020, Nature Communications)
  • Weight gain is an early indicator of injury in ex vivo normothermic limb perfusion (EVNLP) (2022, Artificial Organs)

Henri Brunengraber frequently collaborates with several coauthors, including:

  • Ali Vaziri-Gohar
  • Jonathan J. Hue
  • Rui Wang
  • Jordan M. Winter
  • Mehrdad Zarei

Best Publications

  • A roadmap for interpreting 13 C metabolite labeling patterns from cells

    Joerg M. Buescher;Maciek R. Antoniewicz;Laszlo G. Boros;Shawn C Burgess

  • Correction of 13C mass isotopomer distributions for natural stable isotope abundance.

    Charles A. Fernandez;Christine Des Rosiers;Stephen F. Previs

  • Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting.

    Karin Ekberg;Bernard R. Landau;Alexandre Wajngot;Visvanathan Chandramouli

  • Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride

    Charles R. Roe;Lawrence Sweetman;Diane S. Roe

  • Assessing Cardiac Metabolism

    Heinrich Taegtmeyer;Martin E. Young;Gary D. Lopaschuk;E. Dale Abel

  • Fatty Acid and 3-β-Hydroxysterol Synthesis in the Perfused Rat Liver INCLUDING MEASUREMENTS ON THE PRODUCTION OF LACTATE, PYRUVATE, β-HYDROXYBUTYRATE, AND ACETOACETATE BY THE FED LIVER

    Henri Brunengraber;Mireille Boutry;John M. Lowenstein

  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

    Yujun Hao;Yardena Samuels;Qingling Li;Dawid Krokowski

  • Anaplerotic molecules: Current and future

    Henri Brunengraber;Charles R. Roe

  • Lipogenesis from ketone bodies in the isolated perfused rat liver. Evidence for the cytosolic activation of acetoacetate.

    G. Endemann;P. G. Goetz;J. Edmond;Henri Brunengraber

  • Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy.

    Fanny Mochel;Pascale DeLonlay;Guy Touati;Henri Brunengraber

  • Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

    Dominic P. D'Agostino;Raffaele Pilla;Heather E. Held;Carol S. Landon

  • Assay of low deuterium enrichment of water by isotopic exchange with [U-13C3]acetone and gas chromatography-mass spectrometry

    Dawei Yang;Frédérique Diraison;Michel Beylot;Daniel Z. Brunengraber

  • Isotopomer Analysis of Citric Acid Cycle and Gluconeogenesis in Rat Liver REVERSIBILITY OF ISOCITRATE DEHYDROGENASE AND INVOLVEMENT OF ATP-CITRATE LYASE IN GLUCONEOGENESIS

    Christine Des Rosiers;Lorella Di Donato;Blandine Comte;Annick Laplante

  • Origin of biliary cholesterol and lecithin in the rat: contribution of new synthesis and preformed hepatic stores.

    S. J. Robins;Henri Brunengraber

  • APPLICATIONS OF MASS ISOTOPOMER ANALYSIS TO NUTRITION RESEARCH

    H. Brunengraber;J.K. Kelleher;C. Des Rosiers

  • Partitioning of pyruvate between oxidation and anaplerosis in swine hearts.

    Ashish R. Panchal;Blandine Comte;Hazel Huang;Todd Kerwin

  • Quantifying rates of protein synthesis in humans by use of 2H2O: application to patients with end-stage renal disease

    Stephen F. Previs;Richard Fatica;Visvanathan Chandramouli;James C. Alexander

  • Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.

    C Des Rosiers;C A Fernandez;F David;H Brunengraber

  • Fatty acid synthesis by the liver perfused with deuterated and tritiated water

    Manohar Wadke;Henri Brunengraber;John J.M. Lowenstein;John Dolhun

  • 3-β-Hydroxysterol synthesis by the liver☆

    Henri Brunengraber;J. R. Sabine;Mireille Boutry;J. M. Lowenstein

  • Rates of gluconeogenesis and citric acid cycle in perfused livers, assessed from the mass spectrometric assay of the 13C labeling pattern of glutamate.

    L Di Donato;C Des Rosiers;J A Montgomery;F David

  • [34] Measurement of rates of lipogenesis with deuterated and tritiated water

    J.M. Lowenstein;H. Brunengraber;M. Wadke

  • Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes

    Werner J. Kovacs;Werner J. Kovacs;Khanichi N. Tape;Janis E. Shackelford;Xueying Duan

  • Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart.

    Aneta E. Reszko;Takhar Kasumov;Kathryn A. Jobbins

Frequent Co-Authors

Bernard R. Landau
Bernard R. Landau Case Western Reserve University
Vernon E. Anderson
Vernon E. Anderson Case Western Reserve University
Christine Des Rosiers
Christine Des Rosiers University of Montreal
Charles L. Hoppel
Charles L. Hoppel Case Western Reserve University
Juan Sanabria
Juan Sanabria Marshall University
Srinivasan Dasarathy
Srinivasan Dasarathy Cleveland Clinic
Ron R. Kopito
Ron R. Kopito Stanford University
John M. Lowenstein
John M. Lowenstein Brandeis University
Robert G. Salomon
Robert G. Salomon Case Western Reserve University
Pascal Dubreuil
Pascal Dubreuil University of Montreal

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