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Biology and Biochemistry

D-Index
77
Citations
34398
World Ranking
4682
National Ranking
2267

Overview

Ron R. Kopito is affiliated with Stanford University in the United States, focusing on research in the fields of biochemistry, genetics, and molecular biology. Their work spans multiple subfields including molecular biology, cell biology, oncology, epidemiology, and pulmonary and respiratory medicine. Kopito's research addresses a variety of topics, notably ubiquitin and proteasome pathways, endoplasmic reticulum stress and disease, RNA modifications and cancer, peptidase inhibition and analysis, lipid metabolism and biosynthesis, cystic fibrosis advances, and autophagy in disease and therapy.

Their recent publications demonstrate active inquiries into protein modification mechanisms, ribosome quality control, lipid droplet regulation, and cellular processes involving neurodegenerative disease proteins. Some key papers include:

  • "A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation" (2022), published in The EMBO Journal
  • "RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum" (2023), published in Proceedings of the National Academy of Sciences
  • "Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation" (2023), published in Developmental Cell
  • "Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses" (2020), published in eLife
  • "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER" (2024), published in Nature

The scientist collaborates frequently with several coauthors, including Celeste Riepe, Magda Wąchalska, Paul A. DaRosa, Francesco Scavone, and Samantha C. Gumbin. These collaborations have contributed to a diverse set of outputs.

Kopito regularly publishes in several academic venues. The most frequent include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of Cystic Fibrosis
  • The EMBO Journal
  • Developmental Cell

Best Publications

  • Impairment of the ubiquitin proteasome system by protein aggregation

    Neil F. Bence;Roopal M. Sampat;Ron R. Kopito

  • Aggresomes: A Cellular Response to Misfolded Proteins

    Jennifer A. Johnston;Cristina L. Ward;Ron R. Kopito

  • Aggresomes, inclusion bodies and protein aggregation.

    Ron R Kopito

  • Degradation of CFTR by the ubiquitin-proteasome pathway

    Cristina L. Ward;Satoshi Omura;Ron R. Kopito

  • Misfolded proteins partition between two distinct quality control compartments

    Daniel Kaganovich;Ron Kopito;Judith Frydman

  • Subversion of cellular autophagosomal machinery by RNA viruses.

    William T Jackson;Thomas H Giddings;Matthew P Taylor;Sara Mulinyawe

  • Prion-like transmission of protein aggregates in neurodegenerative diseases

    Patrik Brundin;Ronald Melki;Ron Kopito

  • HDAC6 and Microtubules Are Required for Autophagic Degradation of Aggregated Huntingtin

    Atsushi Iwata;Brigit E. Riley;Jennifer A. Johnston;Ron R. Kopito

  • Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

    Jennifer A. Johnston;Muffie J. Dalton;Mark E. Gurney;Ron R. Kopito

  • ER quality control: the cytoplasmic connection.

    Ron R Kopito

  • Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

    Sachiko Sato;Cristina L. Ward;Mauri E. Krouse;Jeffrey J. Wine

  • Primary structure and transmembrane orientation of the murine anion exchange protein

    Ron R. Kopito;Harvey F. Lodish

  • Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation

    Eric J. Bennett;Neil F. Bence;Rajadas Jayakumar;Rajadas Jayakumar;Ron R. Kopito

  • Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.

    C L Ward;R R Kopito

  • OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

    John C. Christianson;Thomas A. Shaler;Ryan E. Tyler;Ron R. Kopito

  • Global changes to the ubiquitin system in Huntington's disease

    Eric J. Bennett;Thomas A. Shaler;Ben Woodman;Kwon-Yul Ryu

  • Protein misfolding in neurodegenerative diseases: implications and strategies

    Patrick Sweeney;Patrick Sweeney;Hyunsun Park;Marc Baumann;John Dunlop

  • Biosynthesis and degradation of CFTR.

    Ron R. Kopito

  • Defining human ERAD networks through an integrative mapping strategy.

    John C. Christianson;John C. Christianson;James A. Olzmann;Thomas A. Shaler;Mathew E. Sowa

  • Cytoplasmic Penetration and Persistent Infection of Mammalian Cells by Polyglutamine Aggregates

    Pei-Hsien Ren;Jane E. Lauckner;Ioulia Kachirskaia;John E. Heuser

Frequent Co-Authors

Liqun Luo
Liqun Luo Stanford University
Henri Brunengraber
Henri Brunengraber Case Western Reserve University
Joshua E. Elias
Joshua E. Elias Stanford University
Joseph R. Casey
Joseph R. Casey University of Alberta
Israel Sekler
Israel Sekler Ben-Gurion University of the Negev
Ronald Melki
Ronald Melki Centre national de la recherche scientifique, CNRS
Jeffrey J. Wine
Jeffrey J. Wine Stanford University
Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Gillian P. Bates
Gillian P. Bates University College London

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