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Biology and Biochemistry

D-Index
83
Citations
24798
World Ranking
3496
National Ranking
83

Overview

Ronald Melki is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on neurological conditions, with particular attention to the mechanisms and potential treatments of Parkinson's disease and Alzheimer's disease.

Their extensive publication record reflects a deep engagement with medicine and neuroscience as main fields of study. Within these areas, Melki's work spans subfields including neurology, physiology, molecular biology, cellular and molecular neuroscience, and cell biology.

Prominent research topics covered in Melki's work include:

  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Neurological disorders and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Nerve injury and regeneration
  • Neurological diseases and metabolism
  • Botulinum Toxin and Related Neurological Disorders

Melki has contributed to multiple influential papers, some of which include:

  • "Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes," published in 2021 in Cell
  • "The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies," published in 2020 in Acta Neuropathologica
  • "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease," published in 2021 in npj Parkinson's Disease
  • "Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species," published in 2020 in Journal of Biological Chemistry
  • "Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies," published in 2021 in The Journal of Immunology

The scientist frequently collaborates with colleagues such as Luc Bousset, Alexis Fenyi, Virginie Redeker, Tracy Bellande, and Leonidas Stefanis. Their joint research efforts include a substantial number of publications together, with the highest collaboration count being 30 publications with Luc Bousset.

Melki's work has been published often in venues including bioRxiv (Cold Spring Harbor Laboratory), npj Parkinson's Disease, Journal of Biological Chemistry, Biophysical Journal, and PLoS ONE.

Best Publications

  • Actin Depolymerizing Factor (ADF/Cofilin) Enhances the Rate of Filament Turnover: Implication in Actin-based Motility

    Marie-France Carlier;Valérie Laurent;Jérôme Santolini;Ronald Melki

  • α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

    W. Peelaerts;L. Bousset;A. Van der Perren;A. Moskalyuk

  • Structural and functional characterization of two alpha-synuclein strains

    Luc Bousset;Laura Pieri;Gemma Ruiz-Arlandis;Julia Gath

  • α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

    Christian Hansen;Elodie Angot;Ann-Louise Bergström;Jennifer A. Steiner

  • Prion-like transmission of protein aggregates in neurodegenerative diseases

    Patrik Brundin;Ronald Melki;Ron Kopito

  • Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

    Staffan Holmqvist;Oldriska Chutna;Luc Bousset;Patrick Aldrin-Kirk

  • G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

    Suzanne Lesage;Mathieu Anheim;Franck Letournel;Luc Bousset

  • Cytoplasmic Penetration and Persistent Infection of Mammalian Cells by Polyglutamine Aggregates

    Pei-Hsien Ren;Jane E. Lauckner;Ioulia Kachirskaia;John E. Heuser

  • Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

    Eric C. Freundt;Nate Maynard;Eileen K. Clancy;Shyamali Roy

  • Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

    Saïda Abounit;Luc Bousset;Frida Loria;Seng Zhu

  • α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.

    Parvez Alam;Luc Bousset;Ronald Melki;Daniel E. Otzen

  • Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

    Ricardo Guerrero-Ferreira;Nicholas Mi Taylor;Ana-Andreea Arteni;Pratibha Kumari

  • Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

    Laura Pieri;Karine Madiona;Luc Bousset;Ronald Melki

  • Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.

    William P. Flavin;Luc Bousset;Zachary C. Green;Yaping Chu

  • Structure-Function Studies on Small Heat Shock Protein Oligomeric Assembly and Interaction with Unfolded Polypeptides

    Michel R. Leroux;Ronald Melki;Bruce Gordon;Gérard Batelier

  • Prying into the Prion Hypothesis for Parkinson's Disease.

    Patrik Brundin;Ronald Melki

  • Alpha-synuclein transfers from neurons to oligodendrocytes.

    Juan F. Reyes;Nolwen L. Rey;Luc Bousset;Ronald Melki

  • Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

    Nolwen L. Rey;Geraldine H. Petit;Luc Bousset;Ronald Melki

  • Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

    Meryem Tardivel;Séverine Bégard;Luc Bousset;Simon Dujardin;Simon Dujardin

  • α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading

    Frida Loria;Jessica Y Vargas;Luc Bousset;Sylvie Syan

Frequent Co-Authors

Luc Bousset
Luc Bousset Centre national de la recherche scientifique, CNRS
Beat H. Meier
Beat H. Meier ETH Zurich
Anja Böckmann
Anja Böckmann University of Lyon System
Patrik Brundin
Patrik Brundin Roche (United States)
Dominique Pantaloni
Dominique Pantaloni Centre national de la recherche scientifique, CNRS
Antoine Triller
Antoine Triller École Normale Supérieure
Luc Buée
Luc Buée University of Lille
Harm H. Kampinga
Harm H. Kampinga University Medical Center Groningen
Jeffrey H. Kordower
Jeffrey H. Kordower Arizona State University

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