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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
13739
World Ranking
14873
National Ranking
580

Overview

Luc Bousset is affiliated with the Centre national de la recherche scientifique (CNRS) in France, focusing on research within the fields of medicine and biochemistry, genetics, and molecular biology. Their work prominently explores neurology, physiology, molecular biology, cellular and molecular neuroscience, and cell biology.

The scientist's research encompasses several core topics, including:

  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Nerve injury and regeneration
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurological disorders and treatments
  • Neurological diseases and metabolism
  • Peroxisome Proliferator-Activated Receptors

Luc Bousset has contributed to recent publications that reflect these interests. Key papers include:

  • "Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes," 2021, published in Cell
  • "The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies," 2020, published in Acta Neuropathologica
  • "Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species," 2020, published in Journal of Biological Chemistry
  • "Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies," 2021, published in The Journal of Immunology
  • "Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons," 2021, published in Nature Communications

Collaboration is a significant aspect of their work, with frequent co-authors including Ronald Melki, Alexis Fenyi, Erwan Bézard, Domenic Burger, and Henning Stahlberg. These collaborations have resulted in a substantial number of joint publications.

The scientist often publishes research in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Biochemical and Biophysical Research Communications, Methods in Molecular Biology, and EMPIAR dataset.

Best Publications

  • α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

    W. Peelaerts;L. Bousset;A. Van der Perren;A. Moskalyuk

  • Structural and functional characterization of two alpha-synuclein strains

    Luc Bousset;Laura Pieri;Gemma Ruiz-Arlandis;Julia Gath

  • Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

    Staffan Holmqvist;Oldriska Chutna;Luc Bousset;Patrick Aldrin-Kirk

  • G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

    Suzanne Lesage;Mathieu Anheim;Franck Letournel;Luc Bousset

  • Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

    Eric C. Freundt;Nate Maynard;Eileen K. Clancy;Shyamali Roy

  • Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

    Saïda Abounit;Luc Bousset;Frida Loria;Seng Zhu

  • α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.

    Parvez Alam;Luc Bousset;Ronald Melki;Daniel E. Otzen

  • Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

    Ricardo Guerrero-Ferreira;Nicholas Mi Taylor;Ana-Andreea Arteni;Pratibha Kumari

  • Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

    Laura Pieri;Karine Madiona;Luc Bousset;Ronald Melki

  • Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.

    William P. Flavin;Luc Bousset;Zachary C. Green;Yaping Chu

  • Alpha-synuclein transfers from neurons to oligodendrocytes.

    Juan F. Reyes;Nolwen L. Rey;Luc Bousset;Ronald Melki

  • Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

    Nolwen L. Rey;Geraldine H. Petit;Luc Bousset;Ronald Melki

  • Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

    Meryem Tardivel;Séverine Bégard;Luc Bousset;Simon Dujardin;Simon Dujardin

  • α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading

    Frida Loria;Jessica Y Vargas;Luc Bousset;Sylvie Syan

  • α‐synuclein assemblies sequester neuronal α3‐Na+/K+‐ATPase and impair Na+ gradient

    Amulya Nidhi Shrivastava;Virginie Redeker;Nicolas Fritz;Laura Pieri

  • Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

    Simon Dujardin;Séverine Bégard;Raphaëlle Caillierez;Cédrick Lachaud

  • Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.

    Hannah Scheiblich;Cira Dansokho;Dilek Mercan;Susanne V. Schmidt

  • The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

    Anke Van der Perren;Géraldine Gelders;Alexis Fenyi;Luc Bousset

  • LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

    Gregor Bieri;Michel Brahic;Luc Bousset;Julien Couthouis

  • Structure of the Globular Region of the Prion Protein Ure2 from the Yeast Saccharomyces cerevisiae

    Luc Bousset;Hassan Belrhali;Joël Janin;Ronald Melki

Frequent Co-Authors

Ronald Melki
Ronald Melki Centre national de la recherche scientifique, CNRS
Beat H. Meier
Beat H. Meier ETH Zurich
Anja Böckmann
Anja Böckmann University of Lyon System
Luc Buée
Luc Buée University of Lille
Michael T. Heneka
Michael T. Heneka University Hospital Bonn
Patrik Brundin
Patrik Brundin Roche (United States)
Antoine Triller
Antoine Triller École Normale Supérieure
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Michel Brahic
Michel Brahic Stanford University

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