What is he best known for?
The fields of study he is best known for:
- Gene
- Cytokine
- Immune system
Karl Frei spends much of his time researching Immunology, Tumor necrosis factor alpha, Cell biology, Molecular biology and Microglia.
His studies deal with areas such as Meningitis and Central nervous system as well as Immunology.
His Cell biology research incorporates themes from Macrophage, Programmed cell death, Granulocyte macrophage colony-stimulating factor and Granulocyte.
His studies in Molecular biology integrate themes in fields like Apoptosis, Peripheral blood mononuclear cell and Fas ligand.
His work deals with themes such as Receptor and Astrocyte, which intersect with Microglia.
Karl Frei combines subjects such as B cell and Virology with his study of Lymphocytic choriomeningitis.
His most cited work include:
- Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity (742 citations)
- On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. (640 citations)
- Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells (598 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Immunology, Cell biology, Tumor necrosis factor alpha, Pathology and Cancer research.
He interconnects Meningitis, Macrophage and Cerebrospinal fluid in the investigation of issues within Immunology.
His Cell biology study also includes fields such as
- Astrocyte together with Microglia,
- Cerebral cortex that connect with fields like Microvessel.
His Tumor necrosis factor alpha study combines topics from a wide range of disciplines, such as Pathogenesis, Glutamate receptor, Apoptosis, Microbiology and Nitric oxide.
Karl Frei has included themes like Endothelial stem cell and Epilepsy in his Pathology study.
His Glioma research is multidisciplinary, incorporating elements of Molecular biology, Ex vivo and Fas ligand.
He most often published in these fields:
- Immunology (40.00%)
- Cell biology (22.22%)
- Tumor necrosis factor alpha (21.48%)
What were the highlights of his more recent work (between 2012-2020)?
- Cancer research (17.04%)
- Glioma (12.59%)
- Angiogenesis (5.19%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Cancer research, Glioma, Angiogenesis, Pathology and Cell biology.
His study in Cancer research is interdisciplinary in nature, drawing from both Thymosin beta-4, Transforming growth factor, Transforming growth factor beta and Gene silencing.
His research in Glioma intersects with topics in Downregulation and upregulation, Tissue microarray and Cell growth.
His Downregulation and upregulation research is multidisciplinary, incorporating perspectives in Cytokine and Sensitization.
The Angiogenesis study combines topics in areas such as Retina, Neuroscience, Neurovascular bundle and Immunology.
His study explores the link between Cell biology and topics such as Cerebral cortex that cross with problems in Astrocyte, Human brain, Chemokine and Receptor.
Between 2012 and 2020, his most popular works were:
- Wiring the Vascular Network with Neural Cues: A CNS Perspective. (81 citations)
- Nogo-A is a negative regulator of CNS angiogenesis (73 citations)
- Transforming growth factor-β pathway activity in glioblastoma. (55 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Cytokine
- Immune system
His primary scientific interests are in Cancer research, Angiogenesis, Transforming growth factor beta, Retina and Neuroscience.
His biological study spans a wide range of topics, including Neural stem cell, Immunology, Thymosin beta-4, Molecular biology and Gene isoform.
His study in the fields of Tumor microenvironment under the domain of Immunology overlaps with other disciplines such as Vascular endothelial growth factor A.
The study incorporates disciplines such as Growth factor, Platelet-derived growth factor receptor, Messenger RNA, Plasminogen activator and SMAD in addition to Transforming growth factor beta.
The concepts of his Retina study are interwoven with issues in Neurovascular bundle, Central nervous system and Nervous system.
His Neuroscience research incorporates elements of Filopodia and Intracellular, Cell biology.
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