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Karl Frei

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
16848
World Ranking
10085
National Ranking
177

Karl Frei publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Karl Frei sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 149 publications — 26th percentile

26% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Karl Frei D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Karl Frei sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 63 D-Index — 49th percentile

49% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Karl Frei is affiliated with the University of Zurich in Switzerland and has contributed to research primarily within the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their work is concentrated on several subfields including Neurology, Molecular Biology, Cancer Research, Immunology, and Genetics.

Their research topics cover a range of biomedical themes such as Single-cell and spatial transcriptomics, Neuroinflammation and Neurodegeneration Mechanisms, Barrier Structure and Function Studies, MicroRNA in disease regulation, Immune cells in cancer, Neurological disorders and treatments, and Glioma Diagnosis and Treatment.

Karl Frei has authored recent publications across notable journals and platforms. These include:

  • Single-cell atlas of the human brain vasculature across development, adulthood and disease (2024), published in Nature
  • Molecular atlas of the human brain vasculature at the single-cell level (2021), published in bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleolin promotes angiogenesis and endothelial metabolism along the oncofetal axis in the human brain vasculature (2023), published in JCI Insight
  • Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours (2022), published in Anticancer Research
  • Nucleolin is expressed in human fetal brain development and reactivated in human glial brain tumors regulating angiogenesis and vascular metabolism (2020), published in bioRxiv (Cold Spring Harbor Laboratory)

The frequent publication venues where Karl Frei has contributed include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Parkinsonism & Related Disorders
  • Nature
  • JCI Insight
  • Anticancer Research

Collaborations have been established with researchers such as Thomas Wälchli, Moheb Ghobrial, Marc Schwab, Ralph Schlapbach, and Katrien De Bock, indicating a consistent network of coauthors across their publications.

Best Publications

  • Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

    Pascal Schneider;Nils Holler;Jean Luc Bodmer;Michael Hahne

  • On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.

    Karl Frei;Ursula V. Malipiero;Thomas P. Leist;Rolf M. Zinkernagel

  • Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells

    Karl Frei;Christine Siepl;Peter Groscurth;Stefan Bodmer

  • Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

    Melanie Greter;Iva Lelios;Pawel Pelczar;Guillaume Hoeffel

  • Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

    Daniela Piani;Karl Frei;Kim Quang Do;Michel Cuénod

  • Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.

    Hakim Echchannaoui;Karl Frei;Christian Schnell;Stephen L. Leib

  • Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

    Michael Weller;Karl Frei;Peter Groscurth;Peter H. Krammer

  • Increased Secretion of Tumor Necrosis Factor α, Interleukin 1, and Interleukin 6 by Human Mononuclear Cells Exposed to β-Galactoside-specific Lectin from Clinically Applied Mistletoe Extract

    Tibor Hajto;Katarina Hostanska;Karl Frei;Christiane Rordorf

  • T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

    M Wrann;S Bodmer;R de Martin;C Siepl

  • Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL

    David C. S. Huang;Michael Hahne;Michael Schroeter;Karl Frei

  • IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

    Hans-Pietro Eugster;Karl Frei;Manfred Kopf;Hans Lassmann

  • Molecular and cellular permeability control at the blood-brain barrier.

    Sergio M Gloor;Marco Wachtel;Marc F Bolliger;Hideyuki Ishihara

  • Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid

    Paolo Gallo;Karl Frei;Christiane Rordorf;Janis Lazdins

  • Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

    K Frei;T P Leist;A Meager;P Gallo

  • Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

    Michela Zattoni;Maria Luisa Mura;Francine Deprez;Reto A Schwendener

  • Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines

    Daniela Piani;Matthias Spranger;Karl Frei;Andreas Schaffner

  • Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.

    T P Leist;K Frei;S Kam-Hansen;R M Zinkernagel

  • Local Fas/APO-1(CD95) ligand-mediated tumor cell killing in vivo

    Anne Rensing‐Ehl;Karl Frei;Renata Flury;Bernd Matiba

  • Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1.

    Hans-Pietro Eugster;Karl Frei;Rosilla Bachmann;Horst Bluethmann

  • TUMOR NECROSIS FACTOR ALPHA AND LYMPHOTOXIN ALPHA ARE NOT REQUIRED FOR INDUCTION OF ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

    Karl Frei;Hans-Pietro Eugster;Martin Bopst;Cris S. Constantinescu

Frequent Co-Authors

Adriano Fontana
Adriano Fontana University of Zurich
Michael Weller
Michael Weller University of Zurich
Hans Lassmann
Hans Lassmann Medical University of Vienna
Hans-Walter Pfister
Hans-Walter Pfister Ludwig-Maximilians-Universität München
Martin E. Schwab
Martin E. Schwab University of Zurich
David Nadal
David Nadal University of Zurich
Uwe Koedel
Uwe Koedel Ludwig-Maximilians-Universität München
Guido Reifenberger
Guido Reifenberger Heinrich Heine University Düsseldorf
Robert M. Strieter
Robert M. Strieter University of Virginia
Regine Landmann
Regine Landmann University Hospital of Basel

External Links

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Best Scientists Citing Karl Frei

Michael Weller

Michael Weller

University of Zurich

Publications: 123

Adriano Fontana

Adriano Fontana

University of Zurich

Publications: 60

Uwe Koedel

Uwe Koedel

Ludwig-Maximilians-Universität München

Publications: 48

Hans Lassmann

Hans Lassmann

Medical University of Vienna

Publications: 45

Iain L. Campbell

Iain L. Campbell

University of Sydney

Publications: 44

Harald Wajant

Harald Wajant

University of Würzburg

Publications: 43

Pascal Schneider

Pascal Schneider

University of Lausanne

Publications: 38

Etty N. Benveniste

Etty N. Benveniste

University of Alabama at Birmingham

Publications: 36

Georg W. Kreutzberg

Georg W. Kreutzberg

Max Planck Society

Publications: 36

Gregg B. Fields

Gregg B. Fields

Florida Atlantic University

Publications: 35

Hans-Walter Pfister

Hans-Walter Pfister

Ludwig-Maximilians-Universität München

Publications: 35

Marco Prinz

Marco Prinz

University of Freiburg

Publications: 34

Andreas Strasser

Andreas Strasser

Walter and Eliza Hall Institute of Medical Research

Publications: 33

Wolfgang J. Streit

Wolfgang J. Streit

University of Florida

Publications: 30

Richard M. Ransohoff

Richard M. Ransohoff

Harvard University

Publications: 30

Jack P. Antel

Jack P. Antel

McGill University

Publications: 28

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