Karl Frei

Overview

Best Publications

• Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

  Pascal Schneider;Nils Holler;Jean Luc Bodmer;Michael Hahne

  1015
  Citations

• On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.

  Karl Frei;Ursula V. Malipiero;Thomas P. Leist;Rolf M. Zinkernagel

  840
  Citations

• Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells

  Karl Frei;Christine Siepl;Peter Groscurth;Stefan Bodmer

  765
  Citations

• Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

  Melanie Greter;Iva Lelios;Pawel Pelczar;Guillaume Hoeffel

  685
  Citations

• Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

  Daniela Piani;Karl Frei;Kim Quang Do;Michel Cuénod

  554
  Citations

• Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.

  Hakim Echchannaoui;Karl Frei;Christian Schnell;Stephen L. Leib

  442
  Citations

• Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

  Michael Weller;Karl Frei;Peter Groscurth;Peter H. Krammer

  433
  Citations

• Increased Secretion of Tumor Necrosis Factor α, Interleukin 1, and Interleukin 6 by Human Mononuclear Cells Exposed to β-Galactoside-specific Lectin from Clinically Applied Mistletoe Extract

  Tibor Hajto;Katarina Hostanska;Karl Frei;Christiane Rordorf

  429
  Citations

• T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

  M Wrann;S Bodmer;R de Martin;C Siepl

  410
  Citations

• Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL

  David C. S. Huang;Michael Hahne;Michael Schroeter;Karl Frei

  380
  Citations

• IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

  Hans-Pietro Eugster;Karl Frei;Manfred Kopf;Hans Lassmann

  355
  Citations

• Molecular and cellular permeability control at the blood-brain barrier.

  Sergio M Gloor;Marco Wachtel;Marc F Bolliger;Hideyuki Ishihara

  353
  Citations

• Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid

  Paolo Gallo;Karl Frei;Christiane Rordorf;Janis Lazdins

  339
  Citations

• Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

  K Frei;T P Leist;A Meager;P Gallo

  337
  Citations

• Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

  Michela Zattoni;Maria Luisa Mura;Francine Deprez;Reto A Schwendener

  325
  Citations

• Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines

  Daniela Piani;Matthias Spranger;Karl Frei;Andreas Schaffner

  313
  Citations

• Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.

  T P Leist;K Frei;S Kam-Hansen;R M Zinkernagel

  302
  Citations

• Local Fas/APO-1(CD95) ligand-mediated tumor cell killing in vivo

  Anne Rensing‐Ehl;Karl Frei;Renata Flury;Bernd Matiba

  250
  Citations

• Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1.

  Hans-Pietro Eugster;Karl Frei;Rosilla Bachmann;Horst Bluethmann

  250
  Citations

• TUMOR NECROSIS FACTOR ALPHA AND LYMPHOTOXIN ALPHA ARE NOT REQUIRED FOR INDUCTION OF ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

  Karl Frei;Hans-Pietro Eugster;Martin Bopst;Cris S. Constantinescu

  238
  Citations