Karl Frei spends much of his time researching Immunology, Tumor necrosis factor alpha, Cell biology, Molecular biology and Microglia. His studies deal with areas such as Meningitis and Central nervous system as well as Immunology. His Cell biology research incorporates themes from Macrophage, Programmed cell death, Granulocyte macrophage colony-stimulating factor and Granulocyte.
His studies in Molecular biology integrate themes in fields like Apoptosis, Peripheral blood mononuclear cell and Fas ligand. His work deals with themes such as Receptor and Astrocyte, which intersect with Microglia. Karl Frei combines subjects such as B cell and Virology with his study of Lymphocytic choriomeningitis.
His primary areas of investigation include Immunology, Cell biology, Tumor necrosis factor alpha, Pathology and Cancer research. He interconnects Meningitis, Macrophage and Cerebrospinal fluid in the investigation of issues within Immunology. His Cell biology study also includes fields such as
His Tumor necrosis factor alpha study combines topics from a wide range of disciplines, such as Pathogenesis, Glutamate receptor, Apoptosis, Microbiology and Nitric oxide. Karl Frei has included themes like Endothelial stem cell and Epilepsy in his Pathology study. His Glioma research is multidisciplinary, incorporating elements of Molecular biology, Ex vivo and Fas ligand.
His scientific interests lie mostly in Cancer research, Glioma, Angiogenesis, Pathology and Cell biology. His study in Cancer research is interdisciplinary in nature, drawing from both Thymosin beta-4, Transforming growth factor, Transforming growth factor beta and Gene silencing. His research in Glioma intersects with topics in Downregulation and upregulation, Tissue microarray and Cell growth.
His Downregulation and upregulation research is multidisciplinary, incorporating perspectives in Cytokine and Sensitization. The Angiogenesis study combines topics in areas such as Retina, Neuroscience, Neurovascular bundle and Immunology. His study explores the link between Cell biology and topics such as Cerebral cortex that cross with problems in Astrocyte, Human brain, Chemokine and Receptor.
His primary scientific interests are in Cancer research, Angiogenesis, Transforming growth factor beta, Retina and Neuroscience. His biological study spans a wide range of topics, including Neural stem cell, Immunology, Thymosin beta-4, Molecular biology and Gene isoform. His study in the fields of Tumor microenvironment under the domain of Immunology overlaps with other disciplines such as Vascular endothelial growth factor A.
The study incorporates disciplines such as Growth factor, Platelet-derived growth factor receptor, Messenger RNA, Plasminogen activator and SMAD in addition to Transforming growth factor beta. The concepts of his Retina study are interwoven with issues in Neurovascular bundle, Central nervous system and Nervous system. His Neuroscience research incorporates elements of Filopodia and Intracellular, Cell biology.
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Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity
Pascal Schneider;Nils Holler;Jean-Luc Bodmer;Michael Hahne.
Journal of Experimental Medicine (1998)
On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.
Karl Frei;Ursula V. Malipiero;Thomas P. Leist;Rolf M. Zinkernagel.
European Journal of Immunology (1989)
Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells
Karl Frei;Christine Siepl;Peter Groscurth;Stefan Bodmer.
European Journal of Immunology (1987)
Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate
Daniela Piani;Karl Frei;Kim Quang Do;Michel Cuénod.
Neuroscience Letters (1991)
Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.
S Bodmer;K Strommer;K Frei;C Siepl.
Journal of Immunology (1989)
Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.
Hakim Echchannaoui;Karl Frei;Christian Schnell;Stephen L. Leib.
The Journal of Infectious Diseases (2002)
Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.
Michael Weller;Karl Frei;Peter Groscurth;Peter H. Krammer.
Journal of Clinical Investigation (1994)
Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia
Melanie Greter;Iva Lelios;Pawel Pelczar;Guillaume Hoeffel.
Increased Secretion of Tumor Necrosis Factor α, Interleukin 1, and Interleukin 6 by Human Mononuclear Cells Exposed to β-Galactoside-specific Lectin from Clinically Applied Mistletoe Extract
Tibor Hajto;Katarina Hostanska;Karl Frei;Christiane Rordorf.
Cancer Research (1990)
T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.
M Wrann;S Bodmer;R de Martin;C Siepl.
The EMBO Journal (1987)
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