2013 - Hellman Fellow
His primary scientific interests are in Biochemistry, Cell biology, Glutamine, Metabolism and Cell growth. His Pyruvate kinase and PKM2 study are his primary interests in Biochemistry. His Cell biology research includes themes of Cancer cell, Metabolic pathway, Biosynthesis and Flux.
His Glutamine research integrates issues from Lipogenesis, Fatty acid synthesis and Carbohydrate metabolism. Christian M. Metallo integrates several fields in his works, including Lipogenesis and ATP citrate lyase. Many of his studies on Metabolism apply to Lipid metabolism as well.
Cell biology, Biochemistry, Metabolism, Metabolic pathway and Glutamine are his primary areas of study. His Cell biology study integrates concerns from other disciplines, such as Cancer cell, Flux and Carbohydrate metabolism. His work is connected to Citric acid cycle, Lipogenesis, Lipid metabolism, Metabolic flux analysis and Lipid biosynthesis, as a part of Biochemistry.
His Citric acid cycle study deals with Oxidative phosphorylation intersecting with Isocitrate dehydrogenase and Mutation. His biological study spans a wide range of topics, including Catabolism, Fatty acid synthesis and White adipose tissue. In Metabolism, Christian M. Metallo works on issues like Cell growth, which are connected to Cancer research, Cell culture and Cancer.
Christian M. Metallo mostly deals with Cell biology, Metabolism, Internal medicine, Endocrinology and Serine. Christian M. Metallo has included themes like Cancer cell, Beta oxidation, Brown adipose tissue and Pentose phosphate pathway in his Cell biology study. The subject of his Metabolism research is within the realm of Biochemistry.
The Small molecule, Lipogenesis, Lipid Transport and Endogeny research he does as part of his general Biochemistry study is frequently linked to other disciplines of science, such as Sphingosine metabolism, therefore creating a link between diverse domains of science. When carried out as part of a general Endocrinology research project, his work on Catabolism and Lipid metabolism is frequently linked to work in Type 2 diabetes, therefore connecting diverse disciplines of study. His research integrates issues of Glycine, Retinal Defect, Pigmented Epithelium and Biosynthesis in his study of Serine.
Christian M. Metallo focuses on Cell biology, Lipid metabolism, Internal medicine, Endocrinology and Metabolism. His study on Serine is often connected to SPTLC1 as part of broader study in Cell biology. His Lipid metabolism research is multidisciplinary, relying on both Inheritance Patterns, Adipocyte and Pathology.
His study in the field of Apolipoprotein E, White adipose tissue and Catabolism is also linked to topics like Apolipoprotein C-III and Hypertriglyceridemia. His work in the fields of Endocrinology, such as Lipoprotein lipase and Insulin resistance, overlaps with other areas such as Apolipoprotein B and ATP citrate lyase. His research on Metabolism concerns the broader Biochemistry.
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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo;Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini.
Nature (2012)
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso;Shawn M. Davidson;Rengin G. Soydaner-Azeloglu;Seth J. Parker.
Nature (2013)
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis.
Nature Genetics (2011)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Dimitrios Anastasiou;Yimin Yu;William James Israelsen;Jian-Kang Jiang.
Nature Chemical Biology (2012)
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
Daniela Gaglio;Daniela Gaglio;Christian M Metallo;Paulo A Gameiro;Karsten Hiller.
Molecular Systems Biology (2011)
A roadmap for interpreting 13 C metabolite labeling patterns from cells
Joerg M. Buescher;Maciek R. Antoniewicz;Laszlo G. Boros;Shawn C Burgess.
Current Opinion in Biotechnology (2015)
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.
Caroline A. Lewis;Seth J. Parker;Brian P. Fiske;Douglas McCloskey.
Molecular Cell (2014)
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Lei Jiang;Alexander A. Shestov;Pamela Swain;Chendong Yang.
Nature (2016)
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells.
Christian M. Metallo;Jason L. Walther;Gregory Stephanopoulos.
Journal of Biotechnology (2009)
Understanding Metabolic Regulation and Its Influence on Cell Physiology
Christian M. Metallo;Matthew G. Vander Heiden;Matthew G. Vander Heiden.
Molecular Cell (2013)
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