World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
23339
World Ranking
7654
National Ranking
3485

Research.com Recognitions

  • 2013 - Hellman Fellow

Overview

Christian M. Metallo is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Within these fields, the scientist has focused on subfields such as molecular biology, cell biology, physiology, cancer research, and epidemiology.

The main topics of their work include:

  • Metabolism and Genetic Disorders
  • Cancer, Hypoxia, and Metabolism
  • Sphingolipid Metabolism and Signaling
  • Adipose Tissue and Metabolism
  • Mitochondrial Function and Pathology
  • Endoplasmic Reticulum Stress and Disease
  • Peroxisome Proliferator-Activated Receptors

Christian M. Metallo has published frequently in several scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Metabolism
  • Nature
  • Science Advances
  • Cell Metabolism

Frequent co-authors of Metallo include:

  • Thekla Cordes
  • Michal K. Handzlik
  • Martina Wallace
  • Courtney R. Green
  • Jivani M. Gengatharan

Selected recent publications of Christian M. Metallo include:

  • "Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer," 2020, Nature Cell Biology
  • "Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes," 2020, Cell Reports
  • "Fructose stimulated de novo lipogenesis is promoted by inflammation," 2020, Nature Metabolism
  • "Serine restriction alters sphingolipid diversity to constrain tumour growth," 2020, Nature
  • "Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome," 2022, Nature

Christian M. Metallo was awarded the Hellman Fellow recognition in 2013.

Best Publications

  • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

    Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini

  • Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

    Cosimo Commisso;Shawn M. Davidson;Rengin G. Soydaner-Azeloglu;Seth J. Parker

  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

    Dimitrios Anastasiou;Yimin Yu;William James Israelsen;Jian-Kang Jiang

  • A roadmap for interpreting 13 C metabolite labeling patterns from cells

    Joerg M. Buescher;Maciek R. Antoniewicz;Laszlo G. Boros;Shawn C Burgess

  • Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

    Caroline A. Lewis;Seth J. Parker;Brian P. Fiske;Douglas McCloskey

  • Reductive carboxylation supports redox homeostasis during anchorage-independent growth

    Lei Jiang;Alexander A. Shestov;Pamela Swain;Chendong Yang

  • Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

    Daniela Gaglio;Daniela Gaglio;Christian M Metallo;Paulo A Gameiro;Karsten Hiller

  • Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.

    Thekla Cordes;Martina Wallace;Alessandro Michelucci;Ajit S. Divakaruni

  • Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

    Robert U Svensson;Seth J Parker;Lillian J Eichner;Matthew J Kolar

  • Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

    Courtney R Green;Martina Wallace;Ajit S Divakaruni;Susan A Phillips

  • ATP-citrate lyase controls a glucose-to-acetate metabolic switch

    Steven Zhao;AnnMarie Torres;Ryan A. Henry;Sophie Trefely

  • Understanding Metabolic Regulation and Its Influence on Cell Physiology

    Christian M. Metallo;Matthew G. Vander Heiden;Matthew G. Vander Heiden

  • Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

    Xiaoguang Liu;Kellen Olszewski;Yilei Zhang;Esther W Lim

  • Mitochondria as biosynthetic factories for cancer proliferation

    Christopher S Ahn;Christian M Metallo

  • Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells.

    Christian M. Metallo;Jason L. Walther;Gregory Stephanopoulos

  • Metabolic Pathway Alterations that Support Cell Proliferation

    M G Vander Heiden;S Y Lunt;T L Dayton;B P Fiske

  • Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

    Tania Valencia;Ji Young Kim;Shadi Abu-Baker;Jorge Moscat-Pardos

  • Regulation of substrate utilization by the mitochondrial pyruvate carrier

    Nathaniel M. Vacanti;Ajit S. Divakaruni;Courtney R. Green;Seth J. Parker

  • Transaminase inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma

    Samuel K. McBrayer;Jared R. Mayers;Gabriel J. DiNatale;Diana D. Shi

Frequent Co-Authors

Anne N. Murphy
Anne N. Murphy Cytokinetics (United States)
Sean P. Palecek
Sean P. Palecek University of Wisconsin–Madison
Maria T. Diaz-Meco
Maria T. Diaz-Meco Cornell University
Jorge Moscat
Jorge Moscat Cornell University
Mark Mercola
Mark Mercola Cardiovascular Institute of the South
Martin Friedlander
Martin Friedlander Scripps Research Institute
Lewis C. Cantley
Lewis C. Cantley Harvard University
Juan J. de Pablo
Juan J. de Pablo New York University

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