World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
69
Citations
13437
World Ranking
6357
National Ranking
1927

Biology and Biochemistry

D-Index
69
Citations
13470
World Ranking
7563
National Ranking
3437

Overview

Dehua Pei is a researcher affiliated with The Ohio State University in the United States, specializing in the field of Biochemistry, Genetics and Molecular Biology with a strong focus on Molecular Biology. Their scholarly work encompasses various subfields including Immunology, Microbiology, Genetics, and Pulmonary and Respiratory Medicine.

The main topics covered in their research include RNA Interference and Gene Delivery, Advanced Biosensing and Bioanalysis Techniques, Antimicrobial Peptides and Activities, Chemical Synthesis and Analysis, Toxin Mechanisms and Immunotoxins, Protein Kinase Regulation and GTPase Signaling, and Lipid Membrane Structure and Behavior.

Their body of work is published extensively in notable scientific venues. Frequent publication venues include:

  • Journal of Medicinal Chemistry
  • ACS Chemical Biology
  • Journal of the American Chemical Society
  • Molecular Pharmaceutics
  • Nature Communications

Dehua Pei has collaborated with several researchers across different projects. Frequent co-authors include:

  • Ashweta Sahni
  • Ziqing Qian
  • Marina Buyanova
  • Amritendu Koley
  • Heba Salim

Recent publications by Dehua Pei showcase the breadth and depth of their research interests:

  • "Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations" (2024, Nature Communications)
  • "Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse" (2020, ACS Chemical Biology)
  • "How Do Biomolecules Cross the Cell Membrane?" (2022, Accounts of Chemical Research)
  • "Targeting intracellular protein-protein interactions with macrocyclic peptides" (2021, Trends in Pharmacological Sciences)
  • "An intracellular nanobody targeting T4SS effector inhibits Ehrlichia infection" (2021, Proceedings of the National Academy of Sciences)

Dehua Pei's research addresses molecular mechanisms relevant to intracellular delivery, protein-protein interactions, and antimicrobial strategies, highlighting multidisciplinary approaches involving peptide design, deep learning, and molecular modeling.

Best Publications

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • Understanding Cell Penetration of Cyclic Peptides.

    Patrick G Dougherty;Ashweta Sahni;Dehua Pei

  • Overcoming Endosomal Entrapment in Drug Delivery

    Dehua Pei;Marina Buyanova

  • Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides

    Ziqing Qian;Agnieszka Martyna;Ryan L. Hard;Jiang Wang

  • Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains

    Dehua Pei;Ulrike Lorenz;Ulrike Lorenz;Ursula Klingmuller;Benjamin G. Neel;Benjamin G. Neel

  • Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.

    Qing Xiao;Feiran Zhang;Benjamin A. Nacev;Jun O. Liu

  • Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells

    U. Lorenz;K. S. Ravichandran;Dehua Pei;C. T. Walsh

  • PEPTIDE DEFORMYLASE : A NEW TYPE OF MONONUCLEAR IRON PROTEIN

    P. T. Ravi Rajagopalan;and X. Christopher Yu;Dehua Pei

  • Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.

    Ziqing Qian;Tao Liu;Yu Yu Liu;Roger Briesewitz

  • Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery.

    Ziqing Qian;Jonathan R. LaRochelle;Bisheng Jiang;Wenlong Lian

  • Crystal Structure of the Escherichia coli Peptide Deformylase

    M.K Chan;W Gong;P.T Rajagopalan;B Hao

  • Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains.

    Michael C Sweeney;Anne-Sophie Wavreille;Junguk Park;Jonathan P Butchar

  • Inhibition of Ras Signaling by Blocking Ras–Effector Interactions with Cyclic Peptides

    Punit Upadhyaya;Ziqing Qian;Nicholas G. Selner;Sarah R. Clippinger

  • Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1

    Dehua Pei;Jun Wang;Christopher T. Walsh

  • Macrocycles as protein-protein interaction inhibitors.

    Patrick G. Dougherty;Ziqing Qian;Dehua Pei

  • α-Haloacetophenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine Phosphatases

    Gulnur Arabaci;† Xiao-Chuan Guo;Kirk D. Beebe;and K. Mark Coggeshall

  • Purification, characterization, and inhibition of peptide deformylase from Escherichia coli.

    P. T. Ravi Rajagopalan;and Abhijit Datta;Dehua Pei

  • Bicyclic Peptides as Next-Generation Therapeutics.

    Curran A. Rhodes;Dehua Pei

  • Screening Bicyclic Peptide Libraries for Protein–Protein Interaction Inhibitors: Discovery of a Tumor Necrosis Factor-α Antagonist

    Wenlong Lian;Punit Upadhyaya;Curran A. Rhodes;Yusen Liu

  • S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein.

    Jinge Zhu;Eric Dizin;Xubo Hu;Anne-Sophie Wavreille

  • Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133.

    Rajagopalan Pt;Grimme S;Pei D

Frequent Co-Authors

Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Benjamin G. Neel
Benjamin G. Neel New York University Langone Medical Center
Christopher T. Walsh
Christopher T. Walsh Stanford University
John W. Christman
John W. Christman The Ohio State University
Ross E. Dalbey
Ross E. Dalbey The Ohio State University
David R. Corey
David R. Corey The University of Texas Southwestern Medical Center
Meenakshi Devidas
Meenakshi Devidas St. Jude Children's Research Hospital
Wim G. J. Hol
Wim G. J. Hol University of Washington
Li Ding
Li Ding Washington University in St. Louis
Gang Wu
Gang Wu Washington University in St. Louis

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