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Michael W. Crowder

Michael W. Crowder

D-Index & Metrics

Chemistry

D-Index
43
Citations
5805
World Ranking
17330
National Ranking
4245

Overview

Michael W. Crowder is affiliated with Miami University in the United States and has an extensive body of research primarily focused on the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, including molecular medicine, infectious diseases, epidemiology, molecular biology, and pharmacology.

The main topics of Crowder's research concentrate on antibiotic resistance in bacteria, tuberculosis research and epidemiology, Pneumocystis jirovecii pneumonia detection and treatment, antibiotics pharmacokinetics and efficacy, metabolomics and mass spectrometry studies, pneumonia and respiratory infections, as well as bacterial biofilms and quorum sensing.

Crowder has contributed to multiple publications in well-regarded scientific venues. Frequent publication outlets include:

  • Antimicrobial Agents and Chemotherapy
  • ACS Infectious Diseases
  • Journal of the American Chemical Society
  • ChemMedChem
  • Journal of Inorganic Biochemistry

Notable recent papers authored or coauthored by Crowder demonstrate a focus on metallo-β-lactamase inhibitors and antibiotic resistance mechanisms. These include:

  • "Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants," published in 2021 in Antimicrobial Agents and Chemotherapy
  • "Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe," published in 2021 in Journal of the American Chemical Society
  • "Iminodiacetic Acid as a Novel Metal-Binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development," published in 2020 in ChemMedChem
  • "Probing the mechanisms of inhibition for various inhibitors of metallo-β-lactamases VIM-2 and NDM-1," published in 2020 in Journal of Inorganic Biochemistry
  • "1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity," published in 2021 in European Journal of Medicinal Chemistry

Michael W. Crowder frequently collaborates with several scientists who have coauthored numerous publications alongside them. Notable frequent coauthors include Caitlyn A. Thomas, Zishuo Cheng, Kundi Yang, Walter Fast, and Pei W. Thomas.

Best Publications

  • Hydrolysis of phosphate monoesters: a biological problem with multiple chemical solutions

    John B. Vincent;Michael W. Crowder;B.A. Averill

  • Overexpression, Purification, and Characterization of the Cloned Metallo-β-Lactamase L1 from Stenotrophomonas maltophilia

    Michael W. Crowder;Timothy R. Walsh;Linda Banovic;Margaret Pettit

  • Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1.

    Allie Y. Chen;Pei W. Thomas;Alesha C. Stewart;Alexander Bergstrom

  • The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters

    Lin Cheng Ju;Lin Cheng Ju;Zishuo Cheng;Walter Fast;Robert A. Bonomo

  • Characterization of the metal-binding sites of the beta-lactamase from Bacteroides fragilis.

    Michael W. Crowder;Zhigang Wang;Scott L. Franklin;Edward P. Zovinka

  • Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli

    Liliya A. Yatsunyk;J. Allen Easton;Lydia R. Kim;Stacy A. Sugarbaker

  • A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

    María Natalia Lisa;Antonela Rocio Palacios;Mahesh Aitha;Mariano Martin Gonzalez

  • KINETIC MECHANISM OF METALLO-BETA -LACTAMASE L1 FROM STENOTROPHOMONAS MALTOPHILIA

    Silvia McManus-Munoz;Michael W. Crowder

  • Mechanistic and spectroscopic studies of metallo-β-lactamase NDM-1.

    Hao Yang;Mahesh Aitha;Alyssa M Hetrick;Timothy K Richmond

  • Purple acid phosphatase: a diiron enzyme that catalyzes a direct phospho group transfer to water

    Eugene G. Mueller;Michael W. Crowder;Bruce A. Averill;Jeremy R. Knowles

  • Arabidopsis Glyoxalase II Contains a Zinc/Iron Binuclear Metal Center That Is Essential for Substrate Binding and Catalysis

    Trinity M. Zang;Denise A. Hollman;Patrick A. Crawford;Michael W. Crowder

  • Structural Studies on a Mitochondrial Glyoxalase II

    Gishanthi P. K. Marasinghe;Ian M. Sander;Brian Bennett;Gopalraj Periyannan

  • Flexible Metal Binding of the Metallo-β-lactamase Domain: Glyoxalase II Incorporates Iron, Manganese, and Zinc in Vivo†

    Oliver Schilling;Nathan Wenzel;Melissa Naylor;Andreas Vogel

  • Mutational Analysis of Metallo-β-lactamase CcrA from Bacteroides fragilis†

    Margaret P. Yanchak;Rebecca A. Taylor;Michael W. Crowder

  • Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity

    Zishuo Cheng;Pei W. Thomas;Lincheng Ju;Alexander Bergstrom

  • Direct Evidence That the Reaction Intermediate of Metallo-β-lactamase L1 Is Metal Bound

    James D. Garrity;Brian Bennett;Michael W. Crowder

  • Dimanganese complexes of a septadentate ligand. Functional analogues of the manganese pseudocatalase

    Unknown

  • SPECTROSCOPIC AND KINETICS STUDIES OF A HIGH-SALT-STABILIZED FORM OF THE PURPLE ACID PHOSPHATASE FROM BOVINE SPLEEN

    John B. Vincent;Michael W. Crowder;Bruce A. Averill

  • Metal Binding Asp-120 in Metallo-β-lactamase L1 from Stenotrophomonas maltophilia Plays a Crucial Role in Catalysis

    James D. Garrity;Anne L. Carenbauer;Lissa R. Herron;Michael W. Crowder

  • Role of the Zn1 and Zn2 sites in metallo-beta-lactamase L1.

    Zhenxin Hu;Gopalraj Periyannan;Brian Bennett;Michael W. Crowder

  • 1H NMR and NOE studies of the purple acid phosphatases from porcine uterus and bovine spleen.

    Zhigang Wang;Li June Ming;Lawrence Que;John B. Vincent

Frequent Co-Authors

Robert A. Bonomo
Robert A. Bonomo Case Western Reserve University
Christopher A. Makaroff
Christopher A. Makaroff Miami University
Bruce A. Averill
Bruce A. Averill University of Toledo
Seth M. Cohen
Seth M. Cohen University of California, San Diego
Timothy R. Walsh
Timothy R. Walsh University of Oxford
Robert A. Bonomo
Robert A. Bonomo Case Western Reserve University
Oliver Schilling
Oliver Schilling University of Freiburg
Jeremy R. Knowles
Jeremy R. Knowles Harvard University
Wolfram Meyer-Klaucke
Wolfram Meyer-Klaucke University of Paderborn
Elizabeth D. Getzoff
Elizabeth D. Getzoff Scripps Research Institute

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