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Christine Des Rosiers

Christine Des Rosiers

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
8175
World Ranking
15293
National Ranking
538

Overview

Christine Des Rosiers is affiliated with the University of Montreal in Canada and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans multiple interconnected fields with a strong focus on molecular biology, physiology, genetics, cardiology and cardiovascular medicine, and immunology.

Their research topics cover several specialized areas, including:

  • Metabolomics and Mass Spectrometry Studies
  • Mitochondrial Function and Pathology
  • Cardiovascular Function and Risk Factors
  • Adipose Tissue and Metabolism
  • Inflammatory Bowel Disease
  • Sphingolipid Metabolism and Signaling
  • Lipid Metabolism and Biosynthesis

Christine Des Rosiers has published a range of scientific articles in several frequent venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Metabolism, The FASEB Journal, Inflammatory Bowel Diseases, and Circulation. These venues highlight a broad engagement with high-profile and specialized journals in metabolism, molecular biology, inflammatory disease, and cardiovascular research.

Some selected recent papers that demonstrate the scope and focus of their research include:

  • Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation (2023, Science)
  • Mitochondrial pyruvate carriers are required for myocardial stress adaptation (2020, Nature Metabolism)
  • First characterization of glucose flux through the hexosamine biosynthesis pathway (HBP) in ex vivo mouse heart (2020, Journal of Biological Chemistry)
  • Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice (2020, International Journal of Obesity)
  • Branched chain amino acids selectively promote cardiac growth at the end of the awake period (2021, Journal of Molecular and Cellular Cardiology)

Christine Des Rosiers frequently collaborates with a core group of coauthors that includes Caroline Daneault, Anik Forest, John D. Rioux, Matthieu Ruiz, and Gabrielle Boucher, demonstrating an active engagement in collaborative research projects.

Best Publications

  • Correction of 13C mass isotopomer distributions for natural stable isotope abundance.

    Charles A. Fernandez;Christine Des Rosiers;Stephen F. Previs

  • Assessing Cardiac Metabolism

    Heinrich Taegtmeyer;Martin E. Young;Gary D. Lopaschuk;E. Dale Abel

  • Dystrophin-deficient cardiomyocytes are abnormally vulnerable to mechanical stress-induced contractile failure and injury

    Gawiyou Danialou;Alain S. Comtois;Roy Dudley;George Karpati

  • Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.

    Martin Picard;Boris Jung;Feng Liang;Ilan Azuelos

  • AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation.

    Roselle Gélinas;Florence Mailleux;Justine Dontaine;Laurent Bultot

  • SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.

    Alexandre Janer;Alexandre Janer;Julien Prudent;Julien Prudent;Vincent Paupe;Vincent Paupe;Somayyeh Fahiminiya

  • Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development.

    Mohamed Benderdour;Guy Charron;Denis deBlois;Blandine Comte

  • A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

    Julie Thompson Legault;Julie Thompson Legault;Laura Strittmatter;Jessica Tardif;Rohit Sharma

  • Isotopomer Analysis of Citric Acid Cycle and Gluconeogenesis in Rat Liver REVERSIBILITY OF ISOCITRATE DEHYDROGENASE AND INVOLVEMENT OF ATP-CITRATE LYASE IN GLUCONEOGENESIS

    Christine Des Rosiers;Lorella Di Donato;Blandine Comte;Annick Laplante

  • Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy.

    Maya Khairallah;Maya Khairallah;Ramzi Khairallah;Martin E. Young;Jason R.B. Dyck

  • Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond.

    Matthieu Ruiz;Matthieu Ruiz;François Labarthe;Annik Fortier;Bertrand Bouchard;Bertrand Bouchard

  • Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids

    Cecile Hryhorczuk;Marc Florea;Demetra Rodaros;Isabelle Poirier

  • Partitioning of pyruvate between oxidation and anaplerosis in swine hearts.

    Ashish R. Panchal;Blandine Comte;Hazel Huang;Todd Kerwin

  • Dietary ω-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition

    Karen M. O'Shea;Karen M. O'Shea;Ramzi J. Khairallah;Genevieve C. Sparagna;Wenhong Xu

  • NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.

    Magali Balteau;Nicolas Tajeddine;Carole De Meester;Audrey Ginion

  • Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.

    C Des Rosiers;C A Fernandez;F David;H Brunengraber

  • Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition

    Ramzi J. Khairallah;Genevieve C. Sparagna;Nishanth Khanna;Karen M. O'Shea

  • Evidence of separate pathways for lactate uptake and release by the perfused rat heart

    John C. Chatham;Christine Des Rosiers;John R. Forder

  • Mitochondrial pyruvate carriers are required for myocardial stress adaptation.

    Yuan Zhang;Paul V. Taufalele;Jesse D. Cochran;Isabelle Robillard-Frayne

  • A 13C Mass Isotopomer Study of Anaplerotic Pyruvate Carboxylation in Perfused Rat Hearts

    Blandine Comte;Geneviève Vincent;Bertrand Bouchard;Manon Jetté

Frequent Co-Authors

Jean-Claude Tardif
Jean-Claude Tardif Montreal Heart Institute
Henri Brunengraber
Henri Brunengraber Case Western Reserve University
Bruce G. Allen
Bruce G. Allen Montreal Heart Institute
John D. Rioux
John D. Rioux University of Montreal
Eric A. Shoubridge
Eric A. Shoubridge Montreal Neurological Institute and Hospital
Gary D. Lopaschuk
Gary D. Lopaschuk University of Alberta
Jean-Louis Vanoverschelde
Jean-Louis Vanoverschelde Université Catholique de Louvain
Heidi M. McBride
Heidi M. McBride Montreal Neurological Institute and Hospital
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Luc Bertrand
Luc Bertrand Université Catholique de Louvain

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