Jason R.B. Dyck

Overview

Best Publications

• Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

  Timothy R. Koves;John R. Ussher;Robert C. Noland;Dorothy Slentz

  2076
  Citations

• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

  Morgan D. Fullerton;Sandra Galic;Katarina Marcinko;Sarah Sikkema

  849
  Citations

• Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

  Jayan Nagendran;Stephen L. Archer;Daniel Soliman;Vikram Gurtu

  611
  Citations

• Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury

  Wenjie Wang;Costas J. Schulze;Wilma L. Suarez-Pinzon;Jason R.B. Dyck

  556
  Citations

• Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity

  Debby P Y Koonen;René L. Jacobs;Maria Febbraio;Martin E. Young

  549
  Citations

• Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

  M. Sean McMurtry;Sebastien Bonnet;Xichen Wu;Jason R.B. Dyck

  542
  Citations

• Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

  Justin D Crane;Rengasamy Palanivel;Emilio P Mottillo;Adam L Bujak

  517
  Citations

• Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice

  Renaud Dentin;Fadila Benhamed;Isabelle Hainault;Véronique Fauveau

  512
  Citations

• Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats Role of Increased Expression and Activity of Voltage-Gated Potassium Channels

  Evangelos D. Michelakis;M. Sean McMurtry;Xi Chen Wu;Jason R.B. Dyck

  491
  Citations

• Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart.

  Suzanne Kovacic;Carrie-Lynn M. Soltys;Amy J. Barr;Ichiro Shiojima

  486
  Citations

• AMPK alterations in cardiac physiology and pathology: enemy or ally?

  Jason R. B. Dyck;Gary D. Lopaschuk

  473
  Citations

• A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

  Min Xie;Dou Zhang;Jason R.B. Dyck;Yi-Heng Li

  434
  Citations

• Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension A Basis for Excessive Cell Proliferation and a New Therapeutic Target

  Stephen L. Archer;Glenn Marsboom;Gene H. Kim;Hannah J. Zhang

  427
  Citations

• Activation of AMP-activated Protein Kinase Inhibits Protein Synthesis Associated with Hypertrophy in the Cardiac Myocyte

  Anita Y.M. Chan;Carrie Lynn M. Soltys;Martin E. Young;Christopher G. Proud

  396
  Citations

• Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

  Molly S. Bray;Chad A. Shaw;Michael W.S. Moore;Rodrigo A.P. Garcia;Rodrigo A.P. Garcia

  391
  Citations

• V3 spinal neurons establish a robust and balanced locomotor rhythm during walking.

  Ying Zhang;Sujatha Narayan;Eric Geiman;Guillermo M. Lanuza

  379
  Citations

• A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase.

  Fiona M. Campbell;Ray Kozak;Alese Wagner;Judith Y. Altarejos

  368
  Citations

• In Vivo Gene Transfer of the O2-Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats

  Zlatko I. Pozeg;Evangelos D. Michelakis;M. Sean McMurtry;Bernard Thébaud

  365
  Citations

• Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases.

  Beshay N.M. Zordoky;Ian M. Robertson;Jason R.B. Dyck

  358
  Citations

• Short Communication: Ischemia/Reperfusion Tolerance Is Time-of-Day–Dependent: Mediation by the Cardiomyocyte Circadian Clock

  David J. Durgan;Thomas Pulinilkunnil;Carolina Villegas-Montoya;Merissa E. Garvey

  319
  Citations