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Evangelos D. Michelakis

Evangelos D. Michelakis

D-Index & Metrics

Medicine

D-Index
85
Citations
29355
World Ranking
14518
National Ranking
604

Overview

Evangelos D. Michelakis is affiliated with the University of Alberta in Canada. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Epidemiology, and Oncology.

The scientist's work covers a range of key topics:

  • Pulmonary Hypertension Research and Treatments
  • Cardiovascular Function and Risk Factors
  • RNA modifications and cancer
  • Prostate Cancer Treatment and Research
  • Cancer, Hypoxia, and Metabolism
  • Mitochondrial Function and Pathology
  • Prostate Cancer Diagnosis and Treatment

Recent publications by Evangelos D. Michelakis include:

  • "Mechanical Stiffness Controls Dendritic Cell Metabolism and Function," 2021, published in Cell Reports
  • "Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state," 2022, published in Cell Metabolism
  • "MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex," 2022, published in Molecular Cell
  • "TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure," 2022, published in Science Translational Medicine
  • "Fluorine-18 Prostate-Specific Membrane Antigen-1007 PET/CT vs Multiparametric MRI for Locoregional Staging of Prostate Cancer," 2024, published in JAMA Oncology

The scientist frequently publishes in venues such as:

  • Circulation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • The Journal of Urology
  • Science Translational Medicine

Frequent co-authors collaborating with Evangelos D. Michelakis include:

  • Gopinath Sutendra
  • Yongneng Zhang
  • Alois Haromy
  • Bruno Saleme
  • Adam Kinnaird

Best Publications

  • A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

    Sébastien Bonnet;Stephen L. Archer;Joan Allalunis-Turner;Alois Haromy

  • Metabolic Modulation of Glioblastoma with Dichloroacetate

    E. D. Michelakis;G. Sutendra;P. Dromparis;L. Webster

  • Inflammation, growth factors, and pulmonary vascular remodeling.

    Paul M. Hassoun;Luc Mouthon;Joan A. Barberà;Saadia Eddahibi

  • Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

    E D Michelakis;L Webster;J R Mackey

  • An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats Similarities to Human Pulmonary Arterial Hypertension

    Sébastien Bonnet;Evangelos D. Michelakis;Christopher J. Porter;Miguel A. Andrade-Navarro

  • Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension Comparison With Inhaled Nitric Oxide

    Evangelos Michelakis;Wayne Tymchak;Dale Lien;Linda Webster

  • Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury Evidence That Angiogenesis Participates in Alveolarization

    Bernard Thébaud;Faruqa Ladha;Evangelos D. Michelakis;Monika Sawicka

  • Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension

    Evangelos D. Michelakis;Wayne Tymchak;Dale Lien;Linda DaSilva

  • Relevant issues in the pathology and pathobiology of pulmonary hypertension

    Rubin M Tuder;Stephen L Archer;Peter Dorfmüller;Serpil C Erzurum

  • Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

    Jayan Nagendran;Stephen L. Archer;Daniel Soliman;Vikram Gurtu

  • Hypoxic pulmonary vasoconstriction.

    Rohit Moudgil;Evangelos D. Michelakis;Stephen L. Archer

  • Comprehensive Invasive and Noninvasive Approach to the Right Ventricle–Pulmonary Circulation Unit State of the Art and Clinical and Research Implications

    Hunter C. Champion;Evangelos D. Michelakis;Evangelos D. Michelakis;Paul M. Hassoun

  • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

    M. Sean McMurtry;Sebastien Bonnet;Xichen Wu;Jason R.B. Dyck

  • A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

    Gopinath Sutendra;Adam Kinnaird;Peter Dromparis;Roxane Paulin

  • Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension

    Evangelos D. Michelakis;Wayne Tymchak;Michelle Noga;Linda Webster

  • Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats Role of Increased Expression and Activity of Voltage-Gated Potassium Channels

    Evangelos D. Michelakis;M. Sean McMurtry;Xi Chen Wu;Jason R.B. Dyck

  • Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

    M. Sean McMurtry;Stephen L. Archer;Dario C. Altieri;Sebastien Bonnet

  • The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

    Sebastien Bonnet;Gael Rochefort;Gopinath Sutendra;Stephen L. Archer

  • Differential Distribution of Electrophysiologically Distinct Myocytes in Conduit and Resistance Arteries Determines Their Response to Nitric Oxide and Hypoxia

    Stephen L. Archer;James M.C. Huang;Helen L. Reeve;Václav Hampl

  • Riociguat for Patients With Pulmonary Hypertension Caused by Systolic Left Ventricular Dysfunction A Phase IIb Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Hemodynamic Study

    Diana Bonderman;Stefano Ghio;Stephan B. Felix;Hossein Ardeschir Ghofrani

Frequent Co-Authors

Stephen L. Archer
Stephen L. Archer Queen's University
Jason R.B. Dyck
Jason R.B. Dyck University of Alberta
Gary D. Lopaschuk
Gary D. Lopaschuk University of Alberta
Robert C. Robbins
Robert C. Robbins Stanford University
Gavin Y. Oudit
Gavin Y. Oudit University of Alberta
Paul M. Hassoun
Paul M. Hassoun Johns Hopkins University
Marlene Rabinovitch
Marlene Rabinovitch Stanford University
Dario C. Altieri
Dario C. Altieri The Wistar Institute
William C. Sessa
William C. Sessa Pfizer (United States)
Serpil C. Erzurum
Serpil C. Erzurum Cleveland Clinic Lerner College of Medicine

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