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David Dombrowicz

David Dombrowicz

D-Index & Metrics

Immunology

D-Index
56
Citations
9934
World Ranking
3751
National Ranking
173

Overview

David Dombrowicz is affiliated with Inserm in France and has contributed extensively to research in medicine, with particular focus on immunology, molecular biology, and physiology. Their work spans multiple subfields, including cardiology and cardiovascular medicine as well as surgery.

Their research covers a variety of topics, notably immune cells in cancer, asthma and respiratory diseases, allergic rhinitis and sensitization, liver disease diagnosis and treatment, adipose tissue and metabolism, adipokines, inflammation and metabolic diseases, and IL-33, ST2, and ILC pathways.

Dombrowicz has published in several frequent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Hepatology
  • Nature Communications
  • Archives of Cardiovascular Diseases Supplements
  • Journal of the American College of Cardiology

Recent notable papers include:

  • Hypothalamic bile acid-TGR5 signaling protects from obesity (2021), published in Cell Metabolism
  • Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid (2020), published in Cellular and Molecular Gastroenterology and Hepatology
  • AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) (2020), published in Clinical and Translational Allergy
  • Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues (2020), published in Communications Biology
  • Immune-metabolic interactions in homeostasis and the progression to NASH (2022), published in Trends in Endocrinology and Metabolism

Frequent collaborators of Dombrowicz include Bart Staels, Olivier Molendi-Coste, Laurent Pineau, David Montaigne, and Joel T. Haas. These co-authors have contributed to multiple projects alongside Dombrowicz, enhancing interdisciplinary approaches within their common fields.

Best Publications

  • Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

    I Miyajima;D Dombrowicz;T R Martin;J V Ravetch

  • Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma.

    Valérie Verhasselt;Valérie Verhasselt;Valérie Milcent;Valérie Milcent;Julie Cazareth;Julie Cazareth;Akira Kanda;Akira Kanda;Akira Kanda

  • Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene

    David Dombrowicz;Veronique Flamand;Kristen K. Brigman;Beverly H. Koller

  • Peroxisome Proliferator–activated Receptors α and γ Down-regulate Allergic Inflammation and Eosinophil Activation

    Gaetane Woerly;Kohei Honda;Marc Loyens;Jean-Paul Papin

  • The impact of diet on asthma and allergic diseases

    Valerie Julia;Laurence Macia;David Dombrowicz

  • Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.

    D Dombrowicz;V Flamand;I Miyajima;J V Ravetch

  • Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse

    Isabelle Spik;Céline Brénuchon;Véronique Angéli;Delphine Staumont

  • Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses

    David Dombrowicz;Siqi Lin;Véronique Flamand;Anna T. Brini

  • Expression of Cd28 and Cd86 by Human Eosinophils and Role in the Secretion of Type 1 Cytokines (Interleukin 2 and Interferon γ) Inhibition by Immunoglobulin a Complexes

    Gaëtane Woerly;Nadine Roger;Sylvie Loiseau;David Dombrowicz

  • Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development

    Eric Mosconi;Eric Mosconi;Akila Rekima;Akila Rekima;B. Seitz-Polski;B. Seitz-Polski;A. Kanda;A. Kanda;A. Kanda

  • Peroxisome proliferator–activated receptor γ is expressed in airways and inhibits features of airway remodeling in a mouse asthma model

    Kohei Honda;Philippe Marquillies;Monique Capron;David Dombrowicz

  • Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

    Benoit Pourcet;Mathilde Zecchin;Lise Ferri;Justine Beauchamp

  • Acute Antiinflammatory Properties of Statins Involve Peroxisome Proliferator–Activated Receptor-α via Inhibition of the Protein Kinase C Signaling Pathway

    Réjane Paumelle;Christophe Blanquart;Olivier Briand;Olivier Barbier

  • Human Eosinophils Exert TNF-α and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells

    Fanny Legrand;Virginie Driss;Marie Delbeke;Sylvie Loiseau

  • The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways

    S Navarro;G Cossalter;G Cossalter;C Chiavaroli;A Kanda;A Kanda;A Kanda

  • Hypothalamic bile acid-TGR5 signaling protects from obesity.

    Ashley Castellanos-Jankiewicz;Omar Guzmán-Quevedo;Omar Guzmán-Quevedo;Valérie S. Fénelon;Philippe Zizzari

  • Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

    Denis A. Mogilenko;Joel T. Haas;Laurent L’homme;Sébastien Fleury

  • Eosinophils, allergy and parasites

    David Dombrowicz;Monique Capron

  • IgE-Antibody-Dependent Immunotherapy of Solid Tumors: Cytotoxic and Phagocytic Mechanisms of Eradication of Ovarian Cancer Cells

    Sophia N. Karagiannis;Marguerite G. Bracher;James Hunt;Natalie McCloskey

  • CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung

    Cyrille Mionnet;Vanessa Buatois;Vanessa Buatois;Akira Kanda;Akira Kanda;Akira Kanda;Valerie Milcent;Valerie Milcent

  • p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.

    Céline Cudejko;Kristiaan Wouters;Lucía Fuentes;Sarah Anissa Hannou

Frequent Co-Authors

Bart Staels
Bart Staels University of Lille
Monique Capron
Monique Capron University of Lille
Hannah J. Gould
Hannah J. Gould King's College London
Nicolas Glaichenhaus
Nicolas Glaichenhaus Centre national de la recherche scientifique, CNRS
Sophia N. Karagiannis
Sophia N. Karagiannis King's College London
Jean-Pierre Kinet
Jean-Pierre Kinet Beth Israel Deaconess Medical Center
André Capron
André Capron Institut Pasteur
Erika Jensen-Jarolim
Erika Jensen-Jarolim Medical University of Vienna
Brian J. Sutton
Brian J. Sutton King's College London
Walter Wahli
Walter Wahli University of Lausanne

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