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Toshiyuki Takai

Toshiyuki Takai

D-Index & Metrics

Immunology

D-Index
84
Citations
28225
World Ranking
1358
National Ranking
53

Overview

Toshiyuki Takai is affiliated with Tohoku University in Japan and has contributed extensively to research in immunology and microbiology, with additional work spanning the fields of medicine and neurology. Their research interests focus primarily on immune cell function and interactions, cell adhesion molecules, immune cells in cancer, neuroinflammation and neurodegeneration mechanisms, and immune response and inflammation. Additional topics addressed in their work include monoclonal and polyclonal antibodies research as well as galectins and cancer biology.

Their research outputs have been published in a range of academic venues, notably including:

  • International Immunology
  • The Tohoku Journal of Experimental Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • The EMBO Journal

Frequent collaborators in their research include:

  • Mei-Tzu Su
  • Shota Endo
  • Takaomi C. Saido
  • Taisuke Tomita
  • So Itoi

A selection of recent papers authored by Toshiyuki Takai includes:

  • "Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction," published in 2020 in The EMBO Journal
  • "LILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAs," published in 2022 in OncoImmunology
  • "INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model," published in 2023 in iScience
  • "Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice," published in 2021 in International Immunology
  • "TLR7/8 stress response drives histiocytosis in SLC29A3 disorders," published in 2023 in The Journal of Experimental Medicine

Their work often addresses complex immune regulatory mechanisms and disease models, involving both neurological and immunological dimensions. This research is characterized by interdisciplinary approaches connecting cellular immunology with pathological conditions.

Best Publications

  • Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.

    Masaharu Noda;Shin Shimizu;Tsutomu Tanabe;Toshiyuki Takai

  • Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought conditions

    Yusaku Uga;Kazuhiko Sugimoto;Satoshi Ogawa;Satoshi Ogawa;Jagadish Rane;Jagadish Rane

  • FcR γ chain deletion results in pleiotrophic effector cell defects

    Toshiyuki Takai;Min Li;Diana Sylvestre;Raphael Clynes

  • Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

    Masayoshi Mishina;Toshiyuki Takai;Keiji Imoto;Masaharu Noda

  • Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

    Takako Koga;Masanori Inui;Kazuya Inoue;Sunhwa Kim

  • Augmented humoral and anaphylactic responses in FcγRII-deficient mice

    Toshiyuki Takai;Masao Ono;Masaki Hikida;Hitoshi Ohmori

  • Roles of Fc receptors in autoimmunity.

    Toshiyuki Takai

  • Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors.

    Raphael Clynes;Jay S. Maizes;Rodolphe Guinamard;Masao Ono

  • The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.

    Hiromitsu Hara;Chitose Ishihara;Arata Takeuchi;Takayuki Imanishi

  • Deletion of Fcγ Receptor IIB Renders H-2b Mice Susceptible to Collagen-induced Arthritis

    Takae Yuasa;Satoshi Kubo;Tadashi Yoshino;Azusa Ujike

  • Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.

    Kojiro Sato;Ayako Suematsu;Tomoki Nakashima;Sayaka Takemoto-Kimura

  • Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

    Tomonori Kaifu;Jin Nakahara;Masanori Inui;Kenichi Mishima

  • Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease.

    Akira Nakamura;Takae Yuasa;Azusa Ujike;Masao Ono

  • Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

    Masahiro Shinohara;Takako Koga;Kazuo Okamoto;Shinya Sakaguchi

  • Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin.

    Karel Otero;Isaiah R Turnbull;Pietro Luigi Poliani;William Vermi

  • Fc Receptors and Their Role in Immune Regulation and Autoimmunity

    Toshiyuki Takai

  • Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12

    Amanda L. Blasius;Marina Cella;Marina Cella;Jorge Maldonado;Jorge Maldonado;Toshiyuki Takai;Toshiyuki Takai

  • Role of acetylcholine receptor subunits in gating of the channel.

    Bert Sakmann;Christoph Methfessel;Masayoshi Mishina;Tomoyuki Takahashi;Tomoyuki Takahashi

  • Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells

    Masaki Hikida;Masaharu Mori;Toshiyuki Takai;Ken Ichi Tomochika

  • Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

    Chieko Yokoyama;Toshiyuki Takai;Tadashi Tanabe

  • Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.

    Noriko Takegahara;Hyota Takamatsu;Toshihiko Toyofuku;Tohru Tsujimura

  • Requirement of SH2-containing Protein Tyrosine Phosphatases SHP-1 and SHP-2 for Paired Immunoglobulin-like Receptor B (PIR-B)–mediated Inhibitory Signal

    Akito Maeda;Mari Kurosaki;Masao Ono;Toshiyuki Takai

  • Molecular Cloning of a Novel Murine Cell-surface Glycoprotein Homologous to Killer Cell Inhibitory Receptors

    Keiko Hayami;Daisuke Fukuta;Yasuhiro Nishikawa;Yumi Yamashita

  • Impaired dendritic cell maturation and increased T H 2 responses in PIR-B −/− mice

    Azusa Ujike;Kazuhiko Takeda;Akira Nakamura;Shin Ebihara

Frequent Co-Authors

Motohiko Kondo
Motohiko Kondo Nagoya University
Marco Colonna
Marco Colonna Washington University in St. Louis
Tadashi Tanabe
Tadashi Tanabe University of Tokushima
Jeffrey V. Ravetch
Jeffrey V. Ravetch Rockefeller University
Masahiro Yano
Masahiro Yano National Agriculture and Food Research Organization
Toshihiro Nukiwa
Toshihiro Nukiwa Tohoku University
Hiroshi Takayanagi
Hiroshi Takayanagi University of Tokyo
Toshio Kitamura
Toshio Kitamura University of Tokyo
Yusaku Uga
Yusaku Uga Institute of Crop Science
Toshihide Yamashita
Toshihide Yamashita Osaka University

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Related Online Degrees & Career Pathways

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Understanding the financial outlook is also essential. Salaries can vary widely depending on location and credentials, so reviewing the DNP salary by state can help prospective students and professionals make informed career decisions in Immunology-related nursing fields across the USA.

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