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Microbiology

D-Index
53
Citations
11023
World Ranking
4074
National Ranking
167

Overview

Akira Shibuya is affiliated with the University of Tsukuba in Japan and has a research focus primarily in the fields of Immunology and Microbiology, with additional contributions to Medicine. Their work spans several subfields including Immunology, Molecular Biology, Oncology, Immunology and Allergy, and Surgery.

The main topics studied by Akira Shibuya cover a range of immunological and cellular processes:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immune cells in cancer
  • IL-33, ST2, and ILC Pathways
  • Mast cells and histamine
  • Eosinophilic Esophagitis
  • Asthma and respiratory diseases

The scientist has published extensively in notable journals. Frequent publication venues include:

  • The Journal of Immunology
  • International Immunology
  • Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  • Biochemical and Biophysical Research Communications
  • bioRxiv (Cold Spring Harbor Laboratory)

Some of the recent published papers with notable citation counts are:

  • "Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells", 2020, The Journal of Experimental Medicine
  • "CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke", 2021, Science Immunology
  • "DNAM-1 versus TIGIT: competitive roles in tumor immunity and inflammatory responses", 2021, International Immunology
  • "Type 1 innate lymphoid cells: Soldiers at the front line of immunity", 2020, Biomedical Journal
  • "DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions", 2021, Proceedings of the National Academy of Sciences

Akira Shibuya has collaborated frequently with several researchers, reflecting a broad network of scientific cooperation. Key co-authors include:

  • Kazuko Shibuya
  • Tsukasa Nabekura
  • Chigusa Nakahashi-Oda
  • Kazumasa Kanemaru
  • Satoko Tahara-Hanaoka

Best Publications

  • DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes

    Akira Shibuya;David Campbell;Charles Hannum;Hans Yssel

  • Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes.

    Akira Shibuya;Norihisa Sakamoto;Norihisa Sakamoto;Yoshio Shimizu;Kazuko Shibuya;Kazuko Shibuya

  • Applications of retrovirus-mediated expression cloning.

    M Onishi;S Kinoshita;Y Morikawa;A Shibuya

  • The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.

    Hiromitsu Hara;Chitose Ishihara;Arata Takeuchi;Takayuki Imanishi

  • NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

    Tadepally Lakshmikanth;Shannon Burke;Talib Hassan Ali;Silvia Kimpfler

  • Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2

    Yun Gi Kim;Yun Gi Kim;Kankanam Gamage Sanath Udayanga;Naoya Totsuka;Jason B. Weinberg

  • In vivo effects of recombinant human interleukin-6 in primates: Stimulated production of platelets

    S Asano;A Okano;K Ozawa;T Nakahata

  • Functional characterization of DNAM‐1 (CD226) interaction with its ligands PVR (CD155) and nectin‐2 (PRR‐2/CD112)

    Satoko Tahara‐Hanaoka;Kazuko Shibuya;Yuko Onoda;Hua Zhang

  • Accelerated tumor growth in mice deficient in DNAM-1 receptor.

    Akiko Iguchi-Manaka;Hirayasu Kai;Yumi Yamashita;Kai Shibata

  • Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule

    Kazuko Shibuya;Lewis L Lanier;Joseph H Phillips;Hans D Ochs

  • Efficient screening of retroviral cDNA expression libraries.

    Toshio Kitamura;Mayumi Onishi;Shigemi Kinoshita;Akira Shibuya

  • CD226 (DNAM-1) Is Involved in Lymphocyte Function–associated Antigen 1 Costimulatory Signal for Naive T Cell Differentiation and Proliferation

    Kazuko Shibuya;Jun Shirakawa;Tomie Kameyama;Shin-ichiro Honda

  • A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory

    Akiko Murayama;Kazuhisa Sakura;Mina Nakama;Kayoko Yasuzawa-Tanaka

  • Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

    Tsukasa Nabekura;Minoru Kanaya;Akira Shibuya;Guo Fu

  • A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.

    Masanori Sakaguchi;Tetsuro Shingo;Takuya Shimazaki;Hirotaka James Okano

  • Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor.

    Satoko Tahara-Hanaoka;Kazuko Shibuya;Hirayasu Kai;Akitomo Miyamoto

  • Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

    Satoko Arai;Natsumi Maehara;Yoshihiro Iwamura;Shin ichiro Honda

  • Lymphokine requirement for the generation of natural killer cells from CD34+ hematopoietic progenitor cells

    Akira Shibuya;Kazunari Nagayoshi;Kozo Nakamura;Hiromitsu Nakauchi

  • Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor

    Akira Shibuya;Lewis L. Lanier;Joseph H. Phillips

  • A novel Fc receptor for IgA and IgM is expressed on both hematopoietic and non-hematopoietic tissues.

    Norihisa Sakamoto;Kazuko Shibuya;Yoshio Shimizu;Katsumi Yotsumoto

Frequent Co-Authors

Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Lewis L. Lanier
Lewis L. Lanier University of California, San Francisco
Atsushi Iwama
Atsushi Iwama University of Tokyo
Toshio Kitamura
Toshio Kitamura University of Tokyo
Hitoshi Kikutani
Hitoshi Kikutani Osaka University
Toshiyuki Takai
Toshiyuki Takai Tohoku University
Joseph H. Phillips
Joseph H. Phillips MSD (United States)
Takayuki Sumida
Takayuki Sumida University of Tsukuba
Satoru Takahashi
Satoru Takahashi University of Tsukuba
Grant R. Sutherland
Grant R. Sutherland University of Adelaide

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