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Stephan Krähenbühl

Stephan Krähenbühl

D-Index & Metrics

Medicine

D-Index
82
Citations
21729
World Ranking
16261
National Ranking
243

Overview

Stephan Krähenbühl is a researcher affiliated with the University of Basel in Switzerland. Their work primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with a focus on molecular biology and pharmacology as key subfields.

The research topics addressed by Krähenbühl include pharmacogenetics and drug metabolism, drug transport and resistance mechanisms, and PI3K/AKT/mTOR signaling in cancer. Additional areas of study involve lipoproteins and cardiovascular health, adipose tissue and metabolism, chronic myeloid leukemia treatments, as well as genomics, phytochemicals, and oxidative stress.

Frequent co-authors collaborating with Krähenbühl are Jamal Bouitbir, Urs Duthaler, Miljenko V. Panajatovic, Gerda M. Sanvee, and Noëmi Johanna Roos.

Significant publication venues for Krähenbühl include the International Journal of Molecular Sciences, Biochemical Pharmacology, British Journal of Clinical Pharmacology, The AAPS Journal, and Clinical Pharmacokinetics.

Among recent papers are:

  • "mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle - Roles of Rap1 geranylgeranylation and mitochondrial dysfunction," 2021, Biochemical Pharmacology
  • "Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms," 2020, Biochemical Pharmacology
  • "The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: an Observational Cohort Study," 2021, Journal of General Internal Medicine
  • "Mitochondrial Toxicity Associated with Imatinib and Sorafenib in Isolated Rat Heart Fibers and the Cardiomyoblast H9c2 Cell Line," 2022, International Journal of Molecular Sciences
  • "The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells," 2020, Free Radical Biology and Medicine

Best Publications

  • Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: Meta-analysis of randomized trials

    Christoph Stettler;Sabin Allemann;Peter Jüni;Peter Jüni;Carole A. Cull

  • Drug-related problems in hospitals: a review of the recent literature.

    Anita Krähenbühl-Melcher;Raymond Schlienger;Markus Lampert;Manuel Haschke

  • Long-term metformin use is associated with decreased risk of breast cancer.

    Michael Bodmer;Christian Meier;Stephan Krähenbühl;Susan S. Jick

  • Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

    Michael Bodmer;Christian Meier;Stephan Krähenbühl;Susan S. Jick

  • Fulminant liver failure in association with the emetic toxin of Bacillus cereus

    Hellmut Mahler;Aurelio Pasi;John M. Kramer;Petra Schulte

  • Interaction between grapefruit juice and midazolam in humans

    Hugo H.T. Kupferschmidt;Huy Riem Ha;Walter H. Ziegler;Peter J. Meier

  • The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies.

    Birk Poller;Heike Gutmann;Stephan Krahenbuhl;Babette Weksler

  • Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects.

    Manuel Haschke;Manuel Haschke;Manfred Schuster;Marko Poglitsch;Hans Loibner

  • Toxicity of statins on rat skeletal muscle mitochondria

    Priska Kaufmann;Michael Török;Anja Zahno;Katri Waldhauser

  • Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

    Stephan Krähenbühl;Christine Talos;Sven Fischer;Jürg Reichen;Jürg Reichen

  • Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

    Hugo H. T. Kupferschmidt;Karin E. Fattinger;Huy Riem Ha;Ferenc Follath

  • Dose Adjustment in Patients with Liver Disease

    Fabiola Delcò;Lydia Tchambaz;Raymond Schlienger;Jürgen Drewe

  • Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria.

    Stephan Krahenbuhl;Mei Chang;Eric P. Brass;Charles L. Hoppel

  • Mechanisms of benzarone and benzbromarone-induced hepatic toxicity.

    Priska Kaufmann;Michael Török;Anya Hänni;Paul Roberts

  • Tumor targeting using liposomal antineoplastic drugs.

    Jörg Huwyler;Jürgen Drewe;Stephan Krähenbühl

  • Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier

    Birk Poller;Jürgen Drewe;Stephan Krähenbühl;Jörg Huwyler

  • Bile duct injury and use of cholangiography during laparoscopic cholecystectomy

    U. Giger;M. Ouaissi;S.-F. H. Schmitz;S. Krähenbühl

  • Development and evaluation of a spectrophotometric assay for complex III in isolated mitochondria, tissues and fibroblasts from rats and humans

    Stephan Krähenbühl;Christine Talos;Ulrich Wiesmann;Charles L. Hoppel

  • Statin use and risk of gallstone disease followed by cholecystectomy.

    Michael Bodmer;Yolanda B. Brauchli;Stephan Krähenbühl;Susan S. Jick

  • Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats

    Stephan Krähenbühl;Christine Talos;Bernhard H. Lauterburg;Jürg Reichen

Frequent Co-Authors

Christoph R. Meier
Christoph R. Meier University Hospital of Basel
Luigi Terracciano
Luigi Terracciano University Hospital of Basel
Arthur Zimmermann
Arthur Zimmermann University of Bern
Peter C. Hauser
Peter C. Hauser University of Basel
Bruno Stieger
Bruno Stieger University of Zurich
Susan S. Jick
Susan S. Jick Boston University
Werner J. Pichler
Werner J. Pichler University Hospital of Bern
Markus R. Wenk
Markus R. Wenk Hamad bin Khalifa University
Bruno Hagenbuch
Bruno Hagenbuch University of Kansas
Charles L. Hoppel
Charles L. Hoppel Case Western Reserve University

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