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Pierre-Olivier Couraud

Pierre-Olivier Couraud

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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
28943
World Ranking
1929
National Ranking
35

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Pierre-Olivier Couraud is affiliated with Inserm in France. Their research is predominantly in the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Within these fields, their work has a particular focus on Neurology, Molecular Biology, and Cell Biology, with additional interests occasionally touching on Pulmonary and Respiratory Medicine and Biomaterials.

Their scholarly investigations concentrate on several main topics including Barrier Structure and Function Studies, Kruppel-like factors research, Ferroptosis and cancer prognosis, RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, Nanoparticle-Based Drug Delivery, and Cerebrospinal fluid and hydrocephalus.

Frequent collaborators in their work include Shingo Ito, Takeshi Masuda, Sumio Ohtsuki, Ignacio A. Romero, and Babette B. Weksler.

Their publications appear across a variety of journals and venues, reflecting the multidisciplinary nature of their research:

  • Journal of Controlled Release
  • Fluids and Barriers of the CNS
  • Frontiers in Cellular Neuroscience
  • Pharmaceutics
  • Clinics and Research in Hepatology and Gastroenterology

Representative recent papers authored or coauthored by Pierre-Olivier Couraud include:

  • Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo, 2020, Journal of Controlled Release
  • Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses, 2022, Fluids and Barriers of the CNS
  • A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity, 2022, Frontiers in Cellular Neuroscience
  • Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro, 2020, Pharmaceutics
  • A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy, 2021, Clinics and Research in Hepatology and Gastroenterology

Best Publications

  • Blood-brain barrier-specific properties of a human adult brain endothelial cell line

    B. B. Weksler;E. A. Subileau;N. Perrière;P. Charneau

  • The blood-brain barrier in brain homeostasis and neurological diseases.

    Nicolas Weiss;Florence Miller;Florence Miller;Sylvie Cazaubon;Sylvie Cazaubon;Pierre Olivier Couraud;Pierre Olivier Couraud

  • In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

    Hans C. Helms;N. Joan Abbott;Malgorzata Burek;Romeo Cecchelli

  • The hCMEC/D3 cell line as a model of the human blood brain barrier

    Babette Barbash Weksler;Ignacio A. Romero;Pierre-Olivier Couraud;Pierre-Olivier Couraud;Pierre-Olivier Couraud

  • Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

    Anny-Claude Luissint;Cédric Artus;Cédric Artus;Cédric Artus;Fabienne Glacial;Fabienne Glacial;Fabienne Glacial;Kayathiri Ganeshamoorthy;Kayathiri Ganeshamoorthy;Kayathiri Ganeshamoorthy

  • BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

    L. M. Griep;F. Wolbers;B. de Wagenaar;P. M. ter Braak

  • Strategies to advance translational research into brain barriers

    Edward Neuwelt;N Joan Abbott;Lauren Abrey;William A Banks

  • Regulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

    F. Roux;O. Durieu-Trautmann;N. Chaverot;M. Claire

  • Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

    Gerty Schreibelt;Gijs Kooij;Arie Reijerkerk;Ruben van Doorn

  • Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

    Ramzi Shawahna;Yasuo Uchida;Xavier Declèves;Sumio Ohtsuki

  • Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

    Kathryn Hatherell;Pierre-Olivier Couraud;Ignacio A. Romero;Babette Weksler

  • Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties.

    N Perriere;PH Demeuse;E Garcia;A Regina

  • Successful conservation of a threatened Maculinea butterfly.

    J. A. Thomas;D. J. Simcox;R. T. Clarke

  • ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

    Sandrine Dauchy;Sandrine Dauchy;Fabien Dutheil;Richard J. Weaver;Francine Chassoux

  • ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

    Sandrine Etienne-Manneville;Jean-Baptiste Manneville;Peter Adamson;Barry Wilbourn

  • The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies.

    Birk Poller;Heike Gutmann;Stephan Krahenbuhl;Babette Weksler

  • Differential effects of hydrocortisone and TNFα on tight junction proteins in an in vitro model of the human blood-brain barrier

    Carola Förster;Malgorzata Burek;Ignacio A. Romero;Babette Weksler

  • Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells

    O Durieu-Trautmann;N Chaverot;S Cazaubon;A D Strosberg

  • Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies:

    Luca Cucullo;Pierre-Olivier Couraud;Babette Weksler;Babette Weksler;Ignacio-Andres Romero

  • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model

    Sumio Ohtsuki;Chiemi Ikeda;Yasuo Uchida;Yumi Sakamoto

Frequent Co-Authors

Babette B. Weksler
Babette B. Weksler Cornell University
Ignacio A. Romero
Ignacio A. Romero The Open University
Arthur Donny Strosberg
Arthur Donny Strosberg Scripps Research Institute
Georges E. Grau
Georges E. Grau University of Sydney
Antoine Gessain
Antoine Gessain Institut Pasteur
Sumio Ohtsuki
Sumio Ohtsuki Kumamoto University
Catherine Boileau
Catherine Boileau Université Paris Cité
Joan Montaner
Joan Montaner Autonomous University of Barcelona
Dave S.B. Hoon
Dave S.B. Hoon St. John's University
John Greenwood
John Greenwood University College London

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