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Niek N. Sanders

Niek N. Sanders

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13762
World Ranking
8787
National Ranking
152

Overview

Niek N. Sanders is affiliated with Ghent University in Belgium. Their research focuses on biochemistry, genetics, molecular biology, immunology, microbiology, and medicine, with a significant number of publications in these fields. The subfields they contribute to include molecular biology, immunology, infectious diseases, genetics, and biomedical engineering.

The main topics of their research encompass RNA interference and gene delivery, immunotherapy and immune responses, immune response and inflammation, advanced biosensing and bioanalysis techniques, SARS-CoV-2 and COVID-19 research, viral gastroenteritis research and epidemiology, and virus-based gene therapy research.

Frequent publication venues for Sanders include Molecular Therapy, Angewandte Chemie International Edition, Angewandte Chemie, Journal of Controlled Release, and Frontiers in Immunology.

Frequent coauthors working with Sanders are Zifu Zhong, Bruno G. De Geest, Stefan Lienenklaus, Bart N. Lambrecht, and Kim Deswarte.

Recent publications by Niek N. Sanders include:

  • Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across, 2021, Advanced Drug Delivery Reviews
  • Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles, 2020, Journal of the American Chemical Society
  • Immune cells as tumor drug delivery vehicles, 2020, Journal of Controlled Release
  • Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine, 2021, Angewandte Chemie International Edition
  • Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators, 2021, Journal of the American Chemical Society

Best Publications

  • The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

    Dries Vercauteren;Roosmarijn E. Vandenbroucke;Arwyn Tomos Jones;Joanna Rejman

  • Release mechanisms for polyelectrolyte capsules.

    Bruno G. De Geest;Niek N. Sanders;Gleb B. Sukhorukov;Joseph Demeester

  • N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.

    Oliwia Andries;Séan Mc Cafferty;Stefaan C. De Smedt;Ron Weiss

  • The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type

    Katharina von Gersdorff;Niek N. Sanders;Roosmarijn Vandenbroucke;Stefaan C. De Smedt

  • mRNA as gene therapeutic: how to control protein expression.

    Geertrui Tavernier;Oliwia Andries;Jo Demeester;Niek N. Sanders

  • Intracellularly Degradable Polyelectrolyte Microcapsules

    B. G. De Geest;R. E. Vandenbroucke;A. M. Guenther;G. B. Sukhorukov

  • Three-Dimensional Fluorescence Recovery after Photobleaching with the Confocal Scanning Laser Microscope

    Kevin Braeckmans;Liesbeth Peeters;Niek N. Sanders;Stefaan C. De Smedt

  • Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved

    Ine Lentacker;Bart Geers;Joseph Demeester;Stefaan C De Smedt

  • Cystic fibrosis sputum: a barrier to the transport of nanospheres.

    Niek N. Sanders;Stefaan C. De Smedt;Elsa Van Rompaey;Paul Simoens

  • Drug loaded microbubble design for ultrasound triggered delivery

    Ine Lentacker;Stefaan C. De Smedt;Niek N. Sanders

  • Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

    Olivia M. Merkel;Damiano Librizzi;Andreas Pfestroff;Tino Schurrat

  • Extracellular barriers in respiratory gene therapy.

    Niek Sanders;Carsten Rudolph;Carsten Rudolph;Kevin Braeckmans;Stefaan C. De Smedt

  • The challenge of West Nile virus in Europe: knowledge gaps and research priorities

    A. Rizzoli;M.A. Jiménez-Clavero;L. Barzon;Paolo Cordioli

  • Vitreous : A barrier to nonviral ocular gene therapy

    Liesbeth Peeters;Niek N. Sanders;Kevin Braeckmans;Koen Boussery

  • Ultrasound-Responsive Polymer-Coated Microbubbles That Bind and Protect DNA

    Ine Lentacker;Bruno G. De Geest;Roosmarijn E. Vandenbroucke;Liesbeth Peeters

  • Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design.

    Kevin Buyens;Stefaan C. De Smedt;Kevin Braeckmans;Joseph Demeester

  • Sizing nanomatter in biological fluids by fluorescence single particle tracking.

    Kevin Braeckmans;Kevin Buyens;Wim Bouquet;Chris Vervaet

  • Recent progress in West Nile virus diagnosis and vaccination

    Marina De Filette;Sebastian Ulbert;Michael S Diamond;Niek N Sanders

  • Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery

    Bart Geers;Ine Lentacker;Niek N. Sanders;Joseph Demeester

  • A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum.

    Kevin Buyens;Bart Lucas;Koen Raemdonck;Kevin Braeckmans

Frequent Co-Authors

Stefaan C. De Smedt
Stefaan C. De Smedt Ghent University
Bruno G. De Geest
Bruno G. De Geest Ghent University
Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Olivier De Wever
Olivier De Wever Ghent University
Jo Lambert
Jo Lambert Ghent University Hospital
Koen Raemdonck
Koen Raemdonck Ghent University
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel
Luisa Barzon
Luisa Barzon University of Padua

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