Niek N. Sanders spends much of his time researching Gene delivery, Drug delivery, Nanotechnology, Microbubbles and Biophysics. His Gene delivery research incorporates elements of Molecular biology, Polyethylenimine, Liposome and Pharmacology. His work carried out in the field of Nanotechnology brings together such families of science as Polyelectrolyte and In vivo.
His research integrates issues of Ultrasound guided, Medical physics, Ultrasonic drug delivery and Ultrasound imaging in his study of Microbubbles. His Biophysics research integrates issues from Gene silencing, Fluorescence recovery after photobleaching, Fluorescence and Cationic liposome. His Endocytic cycle research includes elements of Transfection, Clathrin and Cell biology.
His primary areas of study are Biophysics, Cell biology, Transfection, Molecular biology and Liposome. His studies deal with areas such as Nanotechnology, Biochemistry, Fluorescence, Oligonucleotide and Gene delivery as well as Biophysics. He focuses mostly in the field of Gene delivery, narrowing it down to matters related to Microbubbles and, in some cases, Drug delivery, Biomedical engineering and Doxorubicin.
His Transfection research is multidisciplinary, relying on both Messenger RNA, Genetic enhancement and Electroporation. His Molecular biology research is multidisciplinary, incorporating elements of In vitro and Small interfering RNA. The concepts of his Liposome study are interwoven with issues in Chromatography, Genetic transfer and Cationic liposome.
Immune system, Cell biology, Cancer research, Messenger RNA and Innate immune system are his primary areas of study. The various areas that he examines in his Cell biology study include Chlamydia, Chlamydiae and Gram-negative bacteria. His studies in Messenger RNA integrate themes in fields like RNA, Protein expression, Electroporation and Replicon.
His Electroporation study combines topics from a wide range of disciplines, such as In vitro, Transfection, Molecular biology, Genetic enhancement and Intradermal injection. His research in Genetic enhancement intersects with topics in Pharmaceutical sciences, Targeted drug delivery, Drug delivery, Drug carrier and Bone marrow. His biological study spans a wide range of topics, including Vesicle, Biophysics and Antigen-presenting cell.
His scientific interests lie mostly in Messenger RNA, Innate immune system, Cell biology, Immune system and Immunogenicity. The Messenger RNA study combines topics in areas such as RNA, Gene expression, In vitro and Electroporation. His In vitro research is multidisciplinary, incorporating perspectives in Molecular medicine, Transfection, Chemokine, Molecular biology and Virus.
His work deals with themes such as Agonist, Biophysics and Small molecule, which intersect with Innate immune system. Niek N. Sanders has included themes like Replicon, Synthetic biology, Subgenomic mRNA, Gene and RNA-binding protein in his Cell biology study. His Immunogenicity study combines topics in areas such as Protein expression, Recombinant DNA, In vivo, In vivo degradation and Computational biology.
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The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls
Dries Vercauteren;Roosmarijn E. Vandenbroucke;Arwyn Tomos Jones;Joanna Rejman.
Molecular Therapy (2010)
Release mechanisms for polyelectrolyte capsules.
Bruno G. De Geest;Niek N. Sanders;Gleb B. Sukhorukov;Joseph Demeester.
Chemical Society Reviews (2007)
The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type
Katharina von Gersdorff;Niek N. Sanders;Roosmarijn Vandenbroucke;Stefaan C. De Smedt.
Molecular Therapy (2006)
Intracellularly Degradable Polyelectrolyte Microcapsules
B. G. De Geest;R. E. Vandenbroucke;A. M. Guenther;G. B. Sukhorukov.
Advanced Materials (2006)
Three-Dimensional Fluorescence Recovery after Photobleaching with the Confocal Scanning Laser Microscope
Kevin Braeckmans;Liesbeth Peeters;Niek N. Sanders;Stefaan C. De Smedt.
Biophysical Journal (2003)
mRNA as gene therapeutic: how to control protein expression.
Geertrui Tavernier;Oliwia Andries;Jo Demeester;Niek N. Sanders.
Journal of Controlled Release (2011)
Cystic fibrosis sputum: a barrier to the transport of nanospheres.
Niek N. Sanders;Stefaan C. De Smedt;Elsa Van Rompaey;Paul Simoens.
American Journal of Respiratory and Critical Care Medicine (2000)
Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved
Ine Lentacker;Bart Geers;Joseph Demeester;Stefaan C De Smedt.
Molecular Therapy (2010)
Drug loaded microbubble design for ultrasound triggered delivery
Ine Lentacker;Stefaan C. De Smedt;Niek N. Sanders.
Soft Matter (2009)
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
Olivia M. Merkel;Damiano Librizzi;Andreas Pfestroff;Tino Schurrat.
Journal of Controlled Release (2009)
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