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Immunology

D-Index
65
Citations
15420
World Ranking
2845
National Ranking
1346

Overview

Douglas B. Kuhns is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with significant contributions in Immunology, Infectious Diseases, Molecular Biology, Genetics, and Rheumatology.

The main topics of Kuhns's work include Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Immunodeficiency and Autoimmune Disorders, COVID-19 Clinical Research Studies, SARS-CoV-2 and COVID-19 Research, Cell Adhesion Molecules Research, T-cell and B-cell Immunology, and Fungal Infections and Studies.

Frequent publication venues for Kuhns's research include:

  • JCI Insight
  • Blood Cells Molecules and Diseases
  • Journal of Clinical Immunology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Medicine

Some of the recent papers associated with Kuhns cover a range of immunological and clinical topics:

  • "An immune-based biomarker signature is associated with mortality in COVID-19 patients," 2020, JCI Insight
  • "Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19," 2022, Nature Medicine
  • "Lentiviral gene therapy for X-linked chronic granulomatous disease," 2020, Nature Medicine
  • "Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19," 2021, Cell
  • "HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease," 2020, Science

Kuhns frequently collaborates with other researchers including Danielle Fink, Steven M. Holland, Michail S. Lionakis, Luigi D. Notarangelo, and Ottavia M. Delmonte. The number of co-authored works with these colleagues ranges from 12 to 24 publications.

Best Publications

  • STAT3 Mutations in the Hyper-IgE Syndrome

    Steven M. Holland;Frank R. DeLeo;Houda Z. Elloumi;Amy P. Hsu

  • Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

    Amy P. Hsu;Elizabeth P. Sampaio;Javed Khan;Katherine R. Calvo

  • Residual NADPH oxidase and survival in chronic granulomatous disease.

    Douglas B. Kuhns;W. Gregory Alvord;Theo Heller;Jordan J. Feld

  • Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.

    Ji-Liang Gao;D. B. Kuhns;H. L. Tiffany;D. Mcdermott

  • Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

    Miriam Y. Kim;Kyung Rok Yu;Saad S. Kenderian;Marco Ruella

  • Common Severe Infections in Chronic Granulomatous Disease

    Beatriz E. Marciano;Christine Spalding;Alan Fitzgerald;Daphne Mann

  • Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. A preliminary report.

    Steven M. Holland;Eli M. Eisenstein;Douglas B. Kuhns;Maria L. Turner

  • A Hypermorphic Missense Mutation in PLCG2, Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

    Qing Zhou;Geun-Shik Lee;Geun-Shik Lee;Jillian Brady;Shrimati Datta

  • Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

    Donald C. Vinh;Smita Y. Patel;Gulbu Uzel;Victoria L. Anderson

  • Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

    Unknown

  • An immune-based biomarker signature is associated with mortality in COVID-19 patients.

    Michael S. Abers;Ottavia M. Delmonte;Emily E. Ricotta;Jonathan Fintzi

  • Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

    Andrei E. Medvedev;Arnd Lentschat;Arnd Lentschat;Douglas B. Kuhns;Jorge C.G. Blanco

  • CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease.

    Suk See De Ravin;Linhong Li;Xiaolin Wu;Uimook Choi

  • Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency

    Suk See De Ravin;Xiaolin Wu;Susan Moir;Lela Kardava

  • Hematologically important mutations: X-linked chronic granulomatous disease (third update).

    Dirk Roos;Douglas B. Kuhns;Anne Maddalena;Joachim Roesler

  • Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils

    Elizabeth M. Kang;Uimook Choi;Narda Theobald;Gilda Linton

  • Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis

    Elizabeth P. Sampaio;Elizabeth P. Sampaio;Amy P. Hsu;Joseph Pechacek;Hannelore I. Bax;Hannelore I. Bax

  • Lentiviral gene therapy for X-linked chronic granulomatous disease.

    Donald B. Kohn;Claire Booth;Elizabeth M. Kang;Sung-Yun Pai

  • Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).

    Andrew P. Demidowich;Alexandra F. Freeman;Douglas B. Kuhns;Ivona Aksentijevich

  • Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.

    Can Liu;Can Liu;Andrew J. Martins;William W. Lau;Nicholas Rachmaninoff;Nicholas Rachmaninoff

  • Chromothriptic Cure of WHIM Syndrome

    David H. McDermott;Ji-Liang Gao;Qian Liu;Marie Siwicki

  • Increased Circulating Cytokines, Cytokine Antagonists, And E-Selectin After Intravenous Administration Of Endotoxin In Humans

    D B Kuhns;W G Alvord;J I Gallin

Frequent Co-Authors

Harry L. Malech
Harry L. Malech National Institutes of Health
John I. Gallin
John I. Gallin National Institutes of Health
Steven M. Holland
Steven M. Holland National Institute of Allergy and Infectious Diseases
Steven M. Holland
Steven M. Holland University of Georgia
Amy P. Hsu
Amy P. Hsu National Institutes of Health
Alexandra F. Freeman
Alexandra F. Freeman National Institute of Allergy and Infectious Diseases
Gulbu Uzel
Gulbu Uzel National Institute of Allergy and Infectious Diseases
Stefania Pittaluga
Stefania Pittaluga National Institutes of Health
Theo Heller
Theo Heller National Institutes of Health
Kenneth N. Olivier
Kenneth N. Olivier National Institutes of Health

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