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Frans H. H. Leenen

Frans H. H. Leenen

D-Index & Metrics

Medicine

D-Index
74
Citations
26676
World Ranking
19305
National Ranking
816

Overview

Frans H. H. Leenen is affiliated with the University of Ottawa in Canada and specializes in medical research with a strong focus on cardiology and cardiovascular medicine. Their scholarly output spans multiple topics related to cardiovascular health, molecular biology, complementary and alternative medicine, pathology and forensic medicine, as well as physiology.

Their research interests are reflected in their primary fields of study, which include:

  • Medicine

Within this broad area, their subfields of study concentrate mainly on:

  • Cardiology and Cardiovascular Medicine
  • Molecular Biology
  • Complementary and Alternative Medicine
  • Pathology and Forensic Medicine
  • Physiology

The main topics covered in their work offer insight into specific areas of cardiovascular science and related disciplines:

  • Heart Rate Variability and Autonomic Control
  • Cardiovascular and Exercise Physiology
  • Ion Transport and Channel Regulation
  • Heart Failure Treatment and Management
  • Cardiac Health and Mental Health
  • Obstructive Sleep Apnea Research
  • Neuroscience of Respiration and Sleep

Frans H. H. Leenen has contributed to several recent research publications, including:

  • "The effects of high-intensity interval training, Nordic walking and moderate-to-vigorous intensity continuous training on functional capacity, depression and quality of life in patients with coronary artery disease enrolled in cardiac rehabilitation: A randomized controlled trial (CRX study)" (2021), published in Progress in Cardiovascular Diseases
  • "Effects of CPAP on Blood Pressure and Sympathetic Activity in Patients With Diabetes Mellitus, Chronic Kidney Disease, and Resistant Hypertension" (2020), published in CJC Open
  • "Can heat therapy help patients with heart failure?" (2020), published in Artificial Organs
  • "Effects of exercise on BDNF-TrkB signaling in the paraventricular nucleus and rostral ventrolateral medulla in rats post myocardial infarction" (2020), published in Neuropeptides
  • "Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension" (2022), published in American Journal of Physiology-Heart and Circulatory Physiology

Their publications have appeared frequently in the following scholarly venues:

  • American Journal of Physiology-Heart and Circulatory Physiology
  • Canadian Journal of Cardiology
  • Progress in Cardiovascular Diseases
  • CJC Open
  • Artificial Organs

Frequent collaborators in their research include:

  • Mordecai P. Blaustein
  • John M. Hamlyn
  • Frédérique Tesson
  • Jennifer L. Reed
  • Tasuku Terada

Best Publications

  • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)

    Curt D. Furberg;Jackson T. Wright;Barry R Davis;Jeffrey A. Cutler

  • Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care

    Curt D. Furberg;Jackson T. Wright;Barry R. Davis;Jeffrey A. Cutler

  • Outcomes in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone, Amlodipine, and Lisinopril

    Jackson T. Wright;J. Kay Dunn;Jeffrey A. Cutler;Barry R. Davis

  • The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): clinical center recruitment experience.

    Jackson T Wright;William C Cushman;Barry R Davis;Joshua Barzilay

  • Clinical Outcomes in Antihypertensive Treatment of Type 2 Diabetes, Impaired Fasting Glucose Concentration, and Normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

    Paul K. Whelton;Joshua Barzilay;William C. Cushman;Barry R. Davis

  • Changes in the rates of awareness, treatment and control of hypertension in Canada over the past two decades

    Finlay A. McAlister;Kathryn Wilkins;Michel Joffres;Frans H.H. Leenen

  • Results of the Ontario Survey on the Prevalence and Control of Hypertension

    Frans H.H. Leenen;Jean Dumais;Natalie H. McInnis;Penelope Turton

  • How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.

    Mordecai P. Blaustein;Frans H. H. Leenen;Ling Chen;Vera A. Golovina

  • Clinical Events in High-Risk Hypertensive Patients Randomly Assigned to Calcium Channel Blocker Versus Angiotensin-Converting Enzyme Inhibitor in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

    Frans H.H. Leenen;Chuke E. Nwachuku;Henry R. Black;William C. Cushman

  • A solid silver clip for induction of predictable levels of renal hypertension in the rat.

    F H Leenen;W de Jong

  • Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain.

    Shahrier Amin;Hong-Wei Wang;Erona Reza;Stewart C. Whitman

  • Increases in CSF [Na+] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet.

    Bing S. Huang;Bruce N. Van Vliet;Frans H. H. Leenen

  • 17β-Estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats

    Stephanie A. Dean;Junhui Tan;Edward R. O'Brien;Frans H. H. Leenen

  • Both Brain Angiotensin II and “Ouabain” Contribute to Sympathoexcitation and Hypertension in Dahl S Rats on High Salt Intake

    Bing S. Huang;Frans H. H. Leenen

  • Prevention of Sympathetic and Cardiac Dysfunction After Myocardial Infarction in Transgenic Rats Deficient in Brain Angiotensinogen

    Hao Wang;Bing S Huang;Detlev Ganten;Frans H H Leenen Leenen

  • The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats. Effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker.

    M. Ruzicka;Baoxue Yuan;E. Harmsen;F. H. H. Leenen

  • Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring.

    F. H. H. Leenen;T. W. Wilson;P. Bolli;P. Larochelle

  • Role of Diuretics in the Prevention of Heart Failure The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

    Barry R. Davis;Linda B. Piller;Jeffrey A. Cutler;Curt Furberg

  • Brain "ouabain" mediates the sympathoexcitatory and hypertensive effects of high sodium intake in Dahl salt-sensitive rats.

    B. S. Huang;F. H. H. Leenen

  • The central role of the brain aldosterone–“ouabain” pathway in salt-sensitive hypertension

    Frans H.H. Leenen

Frequent Co-Authors

Barry R. Davis
Barry R. Davis The University of Texas Health Science Center at Houston
William C. Cushman
William C. Cushman University of Tennessee Health Science Center
Jeffrey A. Cutler
Jeffrey A. Cutler National Institutes of Health
Jackson T. Wright
Jackson T. Wright Case Western Reserve University
Michael H. Alderman
Michael H. Alderman Albert Einstein College of Medicine
John S. Floras
John S. Floras University Health Network
Alexandre F.R. Stewart
Alexandre F.R. Stewart University of Ottawa
Paul K. Whelton
Paul K. Whelton Tulane University
Curt D. Furberg
Curt D. Furberg Wake Forest University
Ernesto L. Schiffrin
Ernesto L. Schiffrin McGill University

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