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D-Index & Metrics

Genetics

D-Index
65
Citations
26386
World Ranking
2657
National Ranking
190

Overview

Dirk Grimm is affiliated with Heidelberg University in Germany and has made contributions primarily in the fields of Biochemistry, Genetics, and Molecular Biology, with additional work spanning Medicine. Their research output includes a significant focus on Molecular Biology and Genetics as well as Infectious Diseases, Cardiology and Cardiovascular Medicine, and Epidemiology.

The scientist's main areas of research encompass virus-based gene therapy, CRISPR and genetic engineering, RNA interference and gene delivery, viral gastroenteritis research and epidemiology, viral infections and immunology, viral infectious diseases and gene expression in insects, and CAR-T cell therapy research.

  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery
  • Viral gastroenteritis research and epidemiology
  • Viral Infections and Immunology Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • CAR-T cell therapy research

Dirk Grimm has frequently published in several scientific venues, indicating consistent contributions to diverse fields. These venues include bioRxiv (Cold Spring Harbor Laboratory), Molecular Therapy, Molecular Therapy - Methods & Clinical Development, Nature Communications, and Human Gene Therapy.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Therapy
  • Molecular Therapy - Methods & Clinical Development
  • Nature Communications
  • Human Gene Therapy

Collaboration is a notable aspect of their career, with frequent coauthors such as Jihad El Andari, Kathleen Börner, Ellen Wiedtke, Kleopatra Rapti, and Jonas Becker, reflecting ongoing partnerships in research projects.

  • Jihad El Andari
  • Kathleen Börner
  • Ellen Wiedtke
  • Kleopatra Rapti
  • Jonas Becker

Some of the recent papers contributed by Dirk Grimm include:

  • "Loss of epigenetic information as a cause of mammalian aging," 2023, published in Cell
  • "Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants," 2020, published in Nature Communications
  • "Methane formation driven by reactive oxygen species across all living organisms," 2022, published in Nature
  • "Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models," 2021, published in Nature Communications
  • "Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice," 2020, published in Gastroenterology

Best Publications

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

  • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.

    Dirk Grimm;Konrad L. Streetz;Konrad L. Streetz;Catherine L. Jopling;Theresa A. Storm

  • Novel tools for production and purification of recombinant adenoassociated virus vectors.

    Dirk Grimm;Andrea Kern;Karola Rittner;Jürgen A. Kleinschmidt

  • In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

    Dirk Grimm;Joyce S. Lee;Lora Wang;Tushar Desai

  • Single-Nucleotide Polymorphisms in Soybean

    Y. L. Zhu;Y. L. Zhu;Q. J. Song;Q. J. Song;D. L. Hyten;C. P. Van Tassell

  • The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9

    Bassel Akache;Dirk Grimm;Kusum Pandey;Stephen R. Yant

  • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.

    Yann Malato;Syed Naqvi;Nina Schürmann;Raymond Ng

  • From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

    D. Grimm;M. A. Kay

  • Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6

    Dirk Grimm;Mark A Kay;Juergen A Kleinschmidt

  • DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids

    Jason A. King;Ralf Dubielzig;Dirk Grimm;Jürgen A. Kleinschmidt

  • CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox.

    Elena Senís;Chronis Fatouros;Stefanie Große;Ellen Wiedtke

  • Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems

    Poornima Parameswaran;Ella Sklan;Courtney Wilkins;Trever Burgon

  • Subcellular compartmentalization of adeno-associated virus type 2 assembly.

    A Wistuba;A Kern;S Weger;D Grimm

  • Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

    Stephane Heymans;Maarten F. Corsten;Wouter Verhesen;Paolo Carai

  • Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic.

    Jeffery C Giering;Dirk Grimm;Theresa A Storm;Mark A Kay

  • Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system.

    Wim T.J.M.C. Hermens;Olivier Ter Brake;Paul A. Dijkhuizen;Marc A.F. Sonnemans

  • Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

    Dirk Grimm;Lora Wang;Joyce S. Lee;Nina Schürmann

  • Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

    Dirk Grimm;Mark A. Kay

  • Loss of Epigenetic Information as a Cause of Mammalian Aging

    Jae-Hyun Yang;Motoshi Hayano;Patrick Griffin;Joao A. Amorim

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

Frequent Co-Authors

Mark A. Kay
Mark A. Kay Stanford University
Roland Eils
Roland Eils Charité - University Medicine Berlin
Jürgen A. Kleinschmidt
Jürgen A. Kleinschmidt German Cancer Research Center
Ulrike Protzer
Ulrike Protzer Technical University of Munich
Udo Reichl
Udo Reichl Otto-von-Guericke University Magdeburg
Hans-Georg Kräusslich
Hans-Georg Kräusslich Heidelberg University
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Steeve Boulant
Steeve Boulant University of Florida
Joan K. Lunney
Joan K. Lunney Agricultural Research Service
Paul Schnitzler
Paul Schnitzler University Hospital Heidelberg

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