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Medicine

D-Index
91
Citations
35814
World Ranking
11628
National Ranking
5964

Overview

Barry J. Byrne is affiliated with the University of Florida in the United States. Their research spans multiple fields within medicine and biomedical sciences, focusing extensively on gene therapy and genetic disorders.

The primary areas of study for this scientist include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, their work covers several specialized subfields:

  • Molecular Biology
  • Genetics
  • Physiology
  • Rheumatology
  • Psychiatry and Mental Health

Barry J. Byrne's research topics highlight specific biomedical challenges and therapeutic strategies, notably:

  • Lysosomal Storage Disorders Research
  • Glycogen Storage Diseases and Myoclonus
  • Virus-based Gene Therapy Research
  • Child Nutrition and Feeding Issues
  • Neurogenetic and Muscular Disorders Research
  • Muscle Physiology and Disorders
  • Carbohydrate Chemistry and Synthesis

The scientist has contributed to multiple recent papers illustrating these focuses. Selected recent publications include:

  • Current Clinical Applications of In Vivo Gene Therapy with AAVs, 2020, Molecular Therapy
  • Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency, 2021, Molecular Therapy
  • Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial, 2021, The Lancet Neurology
  • Management of Neuroinflammatory Responses to AAV-Mediated Gene Therapies for Neurodegenerative Diseases, 2020, Brain Sciences
  • Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies, 2023, Journal of Clinical Investigation

Barry J. Byrne often collaborates with other researchers, frequently working alongside:

  • Manuela Corti
  • Priya S. Kishnani
  • Benedikt Schoser
  • Tahseen Mozaffar
  • David D. Fuller

The scientist's research outputs have appeared primarily in these publication venues:

  • Molecular Therapy
  • Neuromuscular Disorders
  • Molecular Genetics and Metabolism
  • Physiology
  • Neurology

Best Publications

  • Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart

    Catalin Toma;Mark F. Pittenger;Kevin S. Cahill;Barry J. Byrne

  • Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

    S Zolotukhin;B J Byrne;E Mason;I Zolotukhin

  • Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

    William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal;Artur V. Cideciyan

  • Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.

    Jill W. Miller;Carl R. Urbinati;Patana Teng-umnuay;Myrna G. Stenberg

  • Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization

    Maria B. Grant;W. Stratford May;Sergio Caballero;Gary A. J. Brown

  • Recombinant human acid α-glucosidase Major clinical benefits in infantile-onset Pompe disease

    P. S. Kishnani;D. Corzo;M. Nicolino;B. Byrne

  • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

    Artur V. Cideciyan;Tomas S. Aleman;Sanford L. Boye;Sharon B. Schwartz

  • Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein

    Paul D. Kessler;Gregory M. Podsakoff;Xiaojuan Chen;Susan A. McQuiston

  • Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years

    Samuel G. Jacobson;Artur V. Cideciyan;Ramakrishna Ratnakaram;Elise Heon

  • Pompe disease diagnosis and management guideline

    Priya S Kishnani;Robert D Steiner;Deeksha Bali;Kenneth Berger

  • Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.

    Sergei Zolotukhin;Mark Potter;Irene Zolotukhin;Yoshihisa Sakai

  • Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy.

    Jerry R. Mendell;Nathalie Goemans;Linda P. Lowes;Lindsay N. Alfano

  • Current Clinical Applications of In Vivo Gene Therapy with AAVs.

    Jerry R. Mendell;Jerry R. Mendell;Samiah A. Al-Zaidy;Louise R. Rodino-Klapac;Kimberly Goodspeed

  • Antibody-Based Sensors: Principles, Problems and Potential for Detection of Pathogens and Associated Toxins

    Barry Byrne;Edwina Stack;Niamh Gilmartin;Richard O'Kennedy

  • Recombinant Adeno-Associated Virus Serotype 9 Leads to Preferential Cardiac Transduction In Vivo

    Christina A. Pacak;Cathryn S. Mah;Bijoy D. Thattaliyath;Thomas J. Conlon

  • Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year

    Artur V. Cideciyan;William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal

  • Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

    Mark L. Brantly;Jeffrey D. Chulay;Lili Wang;Christian Mueller

  • Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function The LateTIME Randomized Trial

    Jay H. Traverse;Timothy D. Henry;Stephen G. Ellis;Carl J. Pepine

  • Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

    Sihong Song;Michael Morgan;Tamir Ellis;Amy Poirier

  • Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease

    Marc Nicolino;Barry Byrne;J. E. Wraith;Nancy Leslie

Frequent Co-Authors

David D. Fuller
David D. Fuller University of Florida
Terence R. Flotte
Terence R. Flotte University of Massachusetts Chan Medical School
Priya S. Kishnani
Priya S. Kishnani Duke University
Roland W. Herzog
Roland W. Herzog Indiana University
Nicholas Muzyczka
Nicholas Muzyczka University of Florida
Sergei Zolotukhin
Sergei Zolotukhin University of Florida
Richard O'Kennedy
Richard O'Kennedy Hamad bin Khalifa University
William W. Hauswirth
William W. Hauswirth University of Florida
Benedikt Schoser
Benedikt Schoser Ludwig-Maximilians-Universität München
Richard S. Finkel
Richard S. Finkel St. Jude Children's Research Hospital

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