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Timothy M. Crombleholme

Timothy M. Crombleholme

D-Index & Metrics

Medicine

D-Index
84
Citations
22481
World Ranking
15247
National Ranking
7691

Overview

Timothy M. Crombleholme is affiliated with the University of Connecticut in the United States. Their scholarly work primarily focuses on medical research, with a concentration in surgery and pulmonary and respiratory medicine. The research also encompasses obstetrics and gynecology, molecular biology, and pediatrics, perinatology, and child health.

The scientist's research topics cover a range of areas including congenital diaphragmatic hernia studies, tracheal and airway disorders, neonatal respiratory health research, wound healing and treatments, pregnancy and preeclampsia studies, prenatal screening and diagnostics, and RNA modifications and cancer.

Timothy M. Crombleholme has contributed to several recent papers with notable publications such as:

  • "IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3," The FASEB Journal, 2022
  • "Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene," The American Journal of Human Genetics, 2021
  • "Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes," Genetics in Medicine, 2020
  • "Fetoscopic Endoluminal Tracheal Occlusion for Severe, Left-Sided Congenital Diaphragmatic Hernia," Obstetrics and Gynecology, 2023
  • "Placental Gene Therapy for Fetal Growth Restriction and Preeclampsia: Preclinical Studies and Prospects for Clinical Application," Journal of Clinical Medicine, 2024

Frequent co-authors collaborating with Timothy M. Crombleholme include:

  • Foong-Yen Lim
  • Amy J. Wagner
  • Julia Wynn
  • Rebecca Hernan
  • Christiana Farkouh-Karoleski

Their work has appeared regularly in recognized publication venues, notably:

  • The American Journal of Human Genetics
  • Fetal Diagnosis and Therapy
  • Placenta
  • The FASEB Journal
  • Obstetrics and Gynecology

Timothy M. Crombleholme's research contributions are strongly rooted in clinical and molecular investigations related to congenital conditions, neonatal health, and pregnancy complications. The diversity of publication venues and co-authorship patterns reflect a multidisciplinary approach leveraging expertise across medicine, surgery, and molecular biology to address complex health issues.

Best Publications

  • Fetal lung lesions: Management and outcome

    N.Scott Adzick;Michael R. Harrison;Timothy M. Crombleholme;Alan W. Flake

  • Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung

    Timothy M. Crombleholme;Beverly Coleman;Holly Hedrick;Kenneth Liechty

  • Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele.

    Sutton Ln;Adzick Ns;Bilaniuk Lt;Johnson Mp

  • The EXIT procedure: Experience and outcome in 31 cases

    Sarah Bouchard;Mark P. Johnson;Alan W. Flake;Lori J. Howell

  • Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation.

    Michael T. Longaker;David J. Whitby;N. Scott Adzick;Timothy M. Crombleholme

  • Optimized large-scale production of high titer lentivirus vector pseudotypes.

    Miguel Sena-Esteves;Jessica C. Tebbets;Sabine Steffens;Timothy Crombleholme

  • Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome.

    Holly L Hedrick;Alan W Flake;Timothy M Crombleholme;Lori J Howell

  • Successful fetal surgery for spina bifida

    N Scott Adzick;Leslie N Sutton;Timothy M Crombleholme;Alan W Flake

  • Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair.

    Kenneth W Liechty;N.Scott Adzick;Timothy M Crombleholme

  • Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases.

    Alan W. Flake;Timothy M. Crombleholme;Mark P. Johnson;Lori J. Howell

  • Primary fetal hydrothorax: natural history and management.

    Michael T. Longaker;Jean-Martin Laberge;Jean Dansereau;Jacob C. Langer

  • Human melanoma progression in skin reconstructs : biological significance of bFGF.

    Friedegund Meier;Mark Nesbit;Mei-Yu Hsu;Bernard Martin

  • Studies in fetal wound healing: I. A factor in fetal serum that stimulates deposition of hyaluronic acid.

    Michael T. Longaker;Michael R. Harrison;Timothy M. Crombleholme;Jacob C. Langer

  • Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair.

    Kenneth W. Liechty;Heung B. Kim;N.Scott Adzick;Timothy M. Crombleholme

  • Cystic lung lesions with systemic arterial blood supply: A hybrid of congenital cystic adenomatoid malformation and bronchopulmonary sequestration

    Darrell L Cass;Darrell L Cass;Timothy M Crombleholme;Timothy M Crombleholme;Lori J Howell;Lori J Howell;Perry W Stafford;Perry W Stafford

  • Etiology of intestinal damage in gastroschisis. I: Effects of amniotic fluid exposure and bowel constriction in a fetal lamb model

    Jacob C. Langer;Michael T. Longaker;Timothy M. Crombleholme;Sheldon J. Bond

  • Congenital chest lesions: diagnosis and characterization with prenatal MR imaging.

    Hubbard Am;Adzick Ns;Crombleholme Tm;Coleman Bg

  • Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart

    Joerg Heineke;Mannix Auger-Messier;Jian Xu;Toru Oka

  • Fetal intervention in obstructive uropathy: prognostic indicators and efficacy of intervention.

    Timothy M. Crombleholme;Michael R. Harrison;Mitchell S. Golbus;Michael T. Longaker

  • Fetal myelomeningocele repair: short-term clinical outcomes.

    Mark P Johnson;Leslie N Sutton;Natalie Rintoul;Timothy M Crombleholme

Frequent Co-Authors

N. Scott Adzick
N. Scott Adzick Children's Hospital of Philadelphia
Alan W. Flake
Alan W. Flake Children's Hospital of Philadelphia
Michael T. Longaker
Michael T. Longaker Stanford University
Michael R. Harrison
Michael R. Harrison Duke University
Jacob C. Langer
Jacob C. Langer University of Toronto
Edward D. Verrier
Edward D. Verrier University of Washington
Jack Rychik
Jack Rychik Children's Hospital of Philadelphia
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Roy A. Filly
Roy A. Filly University of California, San Francisco
James M. Wilson
James M. Wilson University of Pennsylvania

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