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Medicine

D-Index
99
Citations
35961
World Ranking
8598
National Ranking
4431

Overview

Alan W. Flake is affiliated with the Children's Hospital of Philadelphia in the United States. Their research concentrates primarily within the field of medicine, with a specific focus on surgery, pulmonary and respiratory medicine, and pediatrics, perinatology, and child health. Substantial contributions have also been made in epidemiology and public health, environmental, and occupational health.

Flake's work covers significant topics including neonatal respiratory health research, congenital diaphragmatic hernia studies, and congenital heart disease studies. Additional areas of focus include congenital anomalies and fetal surgery, neonatal and fetal brain pathology, fetal and pediatric neurological disorders, and tracheal and airway disorders.

Recent research publications by Flake demonstrate engagement with clinical and surgical challenges in neonatal care. Selected papers include:

  • Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation, 2021, Annals of Surgery
  • Artificial placenta and womb technology: Past, current, and future challenges towards clinical translation, 2020, Prenatal Diagnosis
  • Ethics Considerations Regarding Artificial Womb Technology for the Fetonate, 2022, The American Journal of Bioethics
  • The Future of In Utero Gene Therapy, 2020, Molecular Diagnosis & Therapy
  • A supportive physiologic environment for the extreme premature infant: Improving life outside the womb, 2021, Journal of Pediatric Surgery

Frequent coauthors collaborating with Flake include:

  • Marcus G. Davey
  • Felix R. De Bie
  • Barbara E. Coons
  • Kendall M. Lawrence
  • Ryne A. Didier

Flake's publications appear regularly in prominent venues such as:

  • Prenatal Diagnosis
  • Journal of Pediatric Surgery
  • PEDIATRICS
  • Fetal Diagnosis and Therapy
  • Journal of Hepatology

Best Publications

  • Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep

    Kenneth W. Liechty;Tippi C. MacKenzie;Aimen F. Shaaban;Antoneta Radu

  • Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

    Mark A. Kay;Catherine S. Manno;Catherine S. Manno;Margaret V. Ragni;Peter J. Larson;Peter J. Larson

  • AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

    Catherine S. Manno;Amy J. Chew;Sylvia Hutchison;Peter J. Larson

  • Fetal lung lesions: Management and outcome

    N.Scott Adzick;Michael R. Harrison;Timothy M. Crombleholme;Alan W. Flake

  • Mesenchymal stem cells: Paradoxes of passaging

    Elisabeth H Javazon;Kirstin J Beggs;Alan W Flake

  • Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung

    Timothy M. Crombleholme;Beverly Coleman;Holly Hedrick;Kenneth Liechty

  • Correction of congenital diaphragmatic hernia in utero: VI. hard-earned lessons

    Michael R. Harrison;N. Scott Adzick;Alan W. Flake;Russell W. Jennings

  • Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells.

    E D Zanjani;G Almeida-Porada;A G Livingston;A W Flake

  • Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling

    Cara C. Bertozzi;Alec A. Schmaier;Patricia Mericko;Paul R. Hess

  • Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele.

    Sutton Ln;Adzick Ns;Bilaniuk Lt;Johnson Mp

  • Treatment of X-Linked Severe Combined Immunodeficiency by in Utero Transplantation of Paternal Bone Marrow

    Alan W. Flake;Maria Grazia Roncarolo;Jennifer M. Puck;Graza Almeida-Porada

  • The EXIT procedure: Experience and outcome in 31 cases

    Sarah Bouchard;Mark P. Johnson;Alan W. Flake;Lori J. Howell

  • Optimized large-scale production of high titer lentivirus vector pseudotypes.

    Miguel Sena-Esteves;Jessica C. Tebbets;Sabine Steffens;Timothy Crombleholme

  • Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome.

    Holly L Hedrick;Alan W Flake;Timothy M Crombleholme;Lori J Howell

  • Successful fetal surgery for spina bifida

    N Scott Adzick;Leslie N Sutton;Timothy M Crombleholme;Alan W Flake

  • An extra-uterine system to physiologically support the extreme premature lamb.

    Emily A. Partridge;Marcus G. Davey;Matthew A. Hornick;Patrick E. McGovern

  • Plug the lung until it grows (PLUG): A new method to treat congenital diaphragmatic hernia in utero

    M H Hedrick;J M Estes;K M Sullivan;J F Bealer

  • Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.

    E D Zanjani;M G Pallavicini;J L Ascensao;A W Flake

  • Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases.

    Alan W. Flake;Timothy M. Crombleholme;Mark P. Johnson;Lori J. Howell

  • in haemophilia B patients treated with an AAV vector

    Mark A. Kay;Catherine S. Manno;Margaret V. Ragni;Peter J. Larson

Frequent Co-Authors

N. Scott Adzick
N. Scott Adzick Children's Hospital of Philadelphia
Michael R. Harrison
Michael R. Harrison Duke University
Esmail D. Zanjani
Esmail D. Zanjani University of Nevada Reno
Timothy M. Crombleholme
Timothy M. Crombleholme University of Connecticut
Jack Rychik
Jack Rychik Children's Hospital of Philadelphia
Leslie N. Sutton
Leslie N. Sutton University of Pennsylvania
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Roy A. Filly
Roy A. Filly University of California, San Francisco
Jan Deprest
Jan Deprest KU Leuven
Mark A. Rosen
Mark A. Rosen University of Pennsylvania

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