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Biology and Biochemistry

D-Index
62
Citations
13933
World Ranking
10789
National Ranking
191

Overview

Motowo Nakajima is affiliated with Novartis in Switzerland. Their research spans multiple fields, with a primary focus on Medicine as well as Biochemistry, Genetics and Molecular Biology. Within these main disciplines, their work further explores Molecular Biology, Immunology, Infectious Diseases, Epidemiology, and Cell Biology.

The scientist's research covers a variety of topics, including:

  • Heme Oxygenase-1 and Carbon Monoxide
  • COVID-19 Clinical Research Studies
  • Proteoglycans and Glycosaminoglycans Research
  • Glycosylation and Glycoproteins Research
  • Fibroblast Growth Factor Research
  • Photodynamic Therapy Research Studies
  • Autophagy in Disease and Therapy

Frequent co-authors collaborating with Motowo Nakajima include:

  • Kiwamu Takahashi
  • Tohru Tanaka
  • Hidenori Ito
  • Xiao-Kang Li
  • Masahiro Ishizuka

Publications have appeared recurrently in the following venues:

  • International Immunopharmacology
  • Photodiagnosis and Photodynamic Therapy
  • International Journal of Molecular Sciences
  • PLoS ONE
  • Life

Several representative papers authored or co-authored by Nakajima include:

  • Efficacy of 5-aminolevulinic acid and LED photodynamic therapy in cervical intraepithelial neoplasia: A clinical trial, 2020, Photodiagnosis and Photodynamic Therapy
  • Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID-19: A Randomized Controlled Trial, 2022, Archives of Medical Research
  • Heparanase is Involved in Leukocyte Migration, 2020, Advances in Experimental Medicine and Biology
  • 5-Aminolevulinic acid/sodium ferrous citrate enhanced the antitumor effects of programmed cell death-ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model, 2021, Cancer Science
  • Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver, 2020, Archives of Biochemistry and Biophysics

Best Publications

  • Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

    Danny R. Welch;Angels Fabra;Motowo Nakajima

  • Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation

    Ikuo Saiki;Junya Yoneda;Ichiro Azuma;Hideji Fujii

  • Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.

    Motowo Nakajima;Danny R. Welch;Paula N. Belloni;Garth L. Nicolson

  • Human heparanase. Purification, characterization, cloning, and expression.

    Minako Toyoshima;Motowo Nakajima

  • Heparanases and tumor metastasis.

    Motowo Nakajima;Tatsuro Irimura;Garth L. Nicolson

  • Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.

    M Nakajima;T Irimura;N Di Ferrante;G L Nicolson

  • CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration.

    Isamu Okamoto;Yoshiaki Kawano;Hiromasa Tsuiki;Ji Ichiro Sasaki

  • Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation

    Osamu Nagano;Daizo Murakami;Dieter Hartmann;Bart De Strooper

  • Influence of Organ Environment on Extracellular Matrix Degradative Activity and Metastasis of Human Colon Carcinoma Cells

    Motowo Nakajima;Kiyoshi Morikawa;Angels Fabra;Corazon D. Bucana

  • The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site.

    Katsuya Ishihara;Kae Tsutsumi;Shiho Kawane;Motowo Nakajima

  • Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro.

    Masanori Baba;Motowo Nakajima;Dominique Schols;Rudi Pauwels

  • Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line.

    Danny R. Welch;J. E. Bisi;B. E. Miller;D. Conaway

  • Heparanase Expression Correlates with Invasion and Poor Prognosis in Gastric Cancers

    Munenori Takaoka;Yoshio Naomoto;Takaomi Ohkawa;Hirokazu Uetsuka

  • Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy

    Masahiro Ishizuka;Fuminori Abe;Yuki Sano;Kiwamu Takahashi

  • Suramin. A potent inhibitor of melanoma heparanase and invasion.

    M. Nakajima;A. Dechavigny;C. E. Johnson;J.-I. Hamada

  • Inhibition by Retinoic Acid of Type IV Collagenolysis and Invasion through Reconstituted Basement Membrane by Metastatic Rat Mammary Adenocarcinoma Cells

    M. Nakajima;D. Lotan;M. M. Baig;R. M. Carralero

  • Chemically modified heparins as inhibitors of heparan sulfate specific endo-.beta.-glucuronidase (heparanase) of metastatic melanoma cells

    Tatsuro Irimura;Motowo Nakajima;Garth L. Nicolson

  • Structural Recognition by Recombinant Human Heparanase That Plays Critical Roles in Tumor Metastasis: HIERARCHICAL SULFATE GROUPS WITH DIFFERENTIAL EFFECTS AND THE ESSENTIAL TARGET DISULFATED TRISACCHARIDE SEQUENCE *

    Yukihiko Okada;Shuhei Yamada;Minako Toyoshima;Jian Dong

  • Serum matrix metalloproteinase-2 and its density in men with prostate cancer as a new predictor of disease extension

    Kazuo Gohji;Noboru Fujimoto;Isao Hara;Akio Fujii

  • Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

    M J Hendrix;W R Wood;E A Seftor;D Lotan

Frequent Co-Authors

Tatsuro Irimura
Tatsuro Irimura Juntendo University
Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Sohei Kitazawa
Sohei Kitazawa Ehime University
Isaiah J. Fidler
Isaiah J. Fidler The University of Texas MD Anderson Cancer Center
Corazon D. Bucana
Corazon D. Bucana The University of Texas MD Anderson Cancer Center
Danny R. Welch
Danny R. Welch University of Kansas
Kiyoshi Kita
Kiyoshi Kita Nagasaki University
Mikihiko Naito
Mikihiko Naito University of Tokyo
Mary J.C. Hendrix
Mary J.C. Hendrix Northwestern University
Tetsu Akiyama
Tetsu Akiyama University of Tokyo

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