Naoya Fujita

Overview

Best Publications

• Modulation of Akt kinase activity by binding to Hsp90

  Saori Sato;Naoya Fujita;Takashi Tsuruo

  1243
  Citations

• The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer

  Luc Friboulet;Nanxin Li;Ryohei Katayama;Christian C. Lee

  868
  Citations

• Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.

  Takashi Tsuruo;Mikihiko Naito;Akihiro Tomida;Naoya Fujita

  684
  Citations

• Domain Mapping Studies Reveal That the M Domain of hsp90 Serves as a Molecular Scaffold to Regulate Akt-Dependent Phosphorylation of Endothelial Nitric Oxide Synthase and NO Release

  Jason Fontana;David Fulton;Yan Chen;Todd A. Fairchild

  473
  Citations

• Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

  Mika Shimonaka;Mika Shimonaka;Koko Katagiri;Toshinori Nakayama;Naoya Fujita

  440
  Citations

• Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

  Naoya Fujita;Saori Sato;Kazuhiro Katayama;Takashi Tsuruo;Takashi Tsuruo

  438
  Citations

• Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer

  Ken Uchibori;Naohiko Inase;Mitsugu Araki;Mayumi Kamada

  386
  Citations

• Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

  Daisuke Morishita;Ryohei Katayama;Kazuhisa Sekimizu;Takashi Tsuruo

  342
  Citations

• Molecular Identification of Aggrus/T1α as a Platelet Aggregation-inducing Factor Expressed in Colorectal Tumors

  Yukinari Kato;Naoya Fujita;Akiko Kunita;Shigeo Sato

  330
  Citations

• Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.

  Yongke Zhang;Naoya Fujita;Takashi Tsuruo;Takashi Tsuruo

  329
  Citations

• Two novel ALK mutations mediate acquired resistance to the next generation ALK inhibitor alectinib

  Ryohei Katayama;Luc Friboulet;Sumie Koike;Elizabeth L. Lockerman

  318
  Citations

• Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.

  Tetsuo Mashima;Mikihiko Naito;Naoya Fujita;Kohji Noguchi

  287
  Citations

• Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)

  Saori Sato;Naoya Fujita;Takashi Tsuruo;Takashi Tsuruo

  270
  Citations

• Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

  Naoya Fujita;Saori Sato;Atsushi Ishida;Takashi Tsuruo;Takashi Tsuruo

  256
  Citations

• Enhanced Expression of Aggrus (T1alpha/Podoplanin), a Platelet-Aggregation-Inducing Factor in Lung Squamous Cell Carcinoma

  Yukinari Kato;Mika Kaneko;Mika Kaneko;Makoto Sata;Naoya Fujita

  249
  Citations

• Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

  Naoya Fujita;Saori Sato;Takashi Tsuruo;Takashi Tsuruo

  247
  Citations

• Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

  Satoshi Takagi;Shigeo Sato;Tomoko Oh-hara;Miho Takami

  238
  Citations

• Cytotoxic Activity of Tivantinib (ARQ 197) Is Not Due Solely to c-MET Inhibition

  Ryohei Katayama;Aki Aoyama;Takao Yamori;Jie Qi

  218
  Citations

• Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion–Positive Cancer

  Ryohei Katayama;Yuka Kobayashi;Yuka Kobayashi;Luc Friboulet;Elizabeth L. Lockerman

  218
  Citations

• Binding and Phosphorylation of Par-4 by Akt Is Essential for Cancer Cell Survival

  Anindya Goswami;Ravshan Burikhanov;Aurelie de Thonel;Naoya Fujita

  215
  Citations