World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
84
Citations
52914
World Ranking
14808
National Ranking
489

Research.com Recognitions

  • 2015 - Fellow of the Australian Academy of Health and Medical Science

Overview

John Simes is affiliated with the University of Sydney in Australia and has contributed extensively to the field of medicine, with a particular focus on oncology. Their research spans a variety of subfields including pulmonary and respiratory medicine, surgery, cancer research, and genetics. The primary domain of their work centers on oncology, supported by 38 published works in this subfield.

The scientist's research topics cover diverse areas within cancer treatment and management. Key topics of their work include:

  • Gastric Cancer Management and Outcomes
  • Colorectal Cancer Treatments and Studies
  • Cancer Genomics and Diagnostics
  • Lung Cancer Treatments and Mutations
  • Colorectal Cancer Surgical Treatments
  • Health Systems, Economic Evaluations, Quality of Life
  • Glioma Diagnosis and Treatment

John Simes has published research in several prominent medical and oncology journals, with frequent contributions to:

  • Journal of Clinical Oncology (12 publications)
  • Annals of Oncology (8 publications)
  • Annals of Surgical Oncology (3 publications)
  • Neuro-Oncology (2 publications)
  • Trials (2 publications)

Their recent papers include:

  • Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group, 2021, Radiotherapy and Oncology
  • Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances, 2021, JAMA
  • Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis, 2021, The Lancet Oncology
  • A randomized phase II trial of veliparib, radiotherapy, and temozolomide in patients with unmethylated MGMT glioblastoma: the VERTU study, 2021, Neuro-Oncology
  • Preoperative cisplatin, fluorouracil, and docetaxel with or without radiotherapy after poor early response to cisplatin and fluorouracil for resectable oesophageal adenocarcinoma (AGITG DOCTOR): results from a multicentre, randomised controlled phase II trial, 2020, Annals of Oncology

Collaborative work is a significant aspect of their research career. Frequent co-authors include:

  • Subotheni Thavaneswaran
  • Val Gebski
  • Katrin Marie Sjoquist
  • Mandy L. Ballinger
  • David M. Thomas

John Simes was recognized as a Fellow of the Australian Academy of Health and Medical Science in 2015.

Best Publications

  • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.

    C Baigent;L Blackwell;J Emberson

  • Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

    S. MacMahon;B. Neal;C. Tzourio;A. Rodgers

  • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials

    B Mihaylova;J Emberson;L Blackwell

  • Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis

    Katrin M Sjoquist;Bryan H Burmeister;B Mark Smithers;B Mark Smithers;John R Zalcberg

  • Interpretation of the evidence for the efficacy and safety of statin therapy.

    Rory Collins;Christina Reith;Jonathan Emberson;Jane Armitage

  • Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis.

    P M Kearney;L Blackwell;R Collins

  • Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

    Kerry Dwan;Douglas G. Altman;Juan A. Arnaiz;Jill Bloom

  • Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174 000 participants in 27 randomised trials

    J Fulcher;R O'Connell;M Voysey

  • Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis

    Val Gebski;Bryan Burmeister;B Mark Smithers;Kerwyn Foo

  • Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials

    Eric Boersma;Robert A Harrington;David J Moliterno;Harvey White

  • A systematic review of physicians' survival predictions in terminally ill cancer patients

    Paul Glare;Kiran Virik;Mark Jones;Malcolm Hudson

  • Effect of Laparoscopic-Assisted Resection vs Open Resection on Pathological Outcomes in Rectal Cancer: The ALaCaRT Randomized Clinical Trial

    Andrew R. L. Stevenson;Andrew R. L. Stevenson;Michael J. Solomon;John W. Lumley;Peter Hewett

  • Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial

    J O'Brien;H Duncan;G Kirsh;V Allen

  • Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab

    Wendy De Roock;Derek J Jonker;Federica Di Nicolantonio;Andrea Sartore-Bianchi

  • Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

    Jane Armitage;Colin Baigent;Elizabeth Barnes;D John Betteridge

  • Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism

    Timothy A. Brighton;John W. Eikelboom;Kristy Mann;Rebecca Mister

  • Effect of Pravastatin on Coronary Disease Events in Subgroups Defined by Coronary Risk Factors The Prospective Pravastatin Pooling Project

    Frank M. Sacks;Andrew M. Tonkin;James Shepherd;Eugene Braunwald

  • Effect of Pravastatin on Cardiovascular Events in People With Chronic Kidney Disease

    Marcello Tonelli;Chris Isles;Gary C Curhan;Andrew Maxwell Tonkin

  • Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials

    Peter Willeit;Peter Willeit;Paul M Ridker;Paul J Nestel;John Simes

  • Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis

    Michael Fogarty;David A. Osborn;Lisa Askie;Anna Lene Seidler

Frequent Co-Authors

Andrew Tonkin
Andrew Tonkin Monash University
Anthony C. Keech
Anthony C. Keech University of Sydney
Val Gebski
Val Gebski University of Sydney
Harvey D. White
Harvey D. White Auckland City Hospital
John R. Zalcberg
John R. Zalcberg Monash University
David Colquhoun
David Colquhoun University of Queensland
Paul J. Nestel
Paul J. Nestel Baker IDI Heart and Diabetes Institute
Dongsheng Tu
Dongsheng Tu Queen's University
Rory Collins
Rory Collins University of Oxford
Colin Baigent
Colin Baigent University of Oxford

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