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D-Index
114
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52000
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4704
National Ranking
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Overview

Richard J. Samulski is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on gene therapy using virus-based vectors, with extensive work in the fields of biochemistry, genetics, molecular biology, and medicine.

Their subfields of study include genetics, molecular biology, cardiology and cardiovascular medicine, infectious diseases, and animal science and zoology. These areas of specialization reflect a broad engagement with both fundamental and applied biomedical research.

Key topics covered in their work include:

  • Virus-based gene therapy research
  • RNA interference and gene delivery
  • Viral infectious diseases and gene expression in insects
  • Viral infections and immunology research
  • CRISPR and genetic engineering
  • Animal virus infections studies
  • Viral gastroenteritis research and epidemiology

Among their recent publications are several notable papers:

  • Engineering adeno-associated virus vectors for gene therapy, 2020, Nature Reviews Genetics
  • AAV vectors: The Rubik's cube of human gene therapy, 2022, Molecular Therapy
  • BAX 335 hemophilia B gene therapy clinical trial results: potential impact of CpG sequences on gene expression, 2020, Blood
  • Addressing high dose AAV toxicity - 'one and done' or 'slower and lower'?, 2022, Expert Opinion on Biological Therapy
  • Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression, 2020, Human Gene Therapy

Richard J. Samulski frequently collaborates with a core group of researchers, including Chengwen Li, Matthew L. Hirsch, Joshua C. Grieger, Steven J. Gray, and Laurie R. Goodrich. These frequent coauthorships indicate sustained collaborative efforts in advancing gene therapy methodologies and applications.

Their research outputs have been published predominantly in specialized venues such as UNC Libraries, Molecular Therapy, Human Gene Therapy, Molecular Therapy - Methods & Clinical Development, and bioRxiv (Cold Spring Harbor Laboratory). This publication history highlights a focused dissemination strategy within the gene therapy and molecular biology communities.

Best Publications

  • Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus

    Xiao Xiao;Juan Li;Richard Jude Samulski

  • Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

    Candace Summerford;Richard Jude Samulski

  • Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

    S Zolotukhin;B J Byrne;E Mason;I Zolotukhin

  • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

    Michael G. Kaplitt;Paola Leone;Richard J. Samulski;Xiao Xiao

  • Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.

    Xiao Xiao;Juan Li;Richard Jude Samulski

  • Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

    Joseph E. Rabinowitz;Fabienne Rolling;Chengwen Li;Hervè Conrath

  • Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression.

    R J Samulski;L S Chang;T Shenk

  • Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis.

    D M McCarty;P E Monahan;R J Samulski

  • AAV transduction vectors

    Nicholas Muzyczka;Paul L. Hermonat;Kenneth I. Berns;Richard J. Samulski

  • αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection

    Candace Summerford;Jeffrey S. Bartlett;Richard Jude Samulski

  • Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors.

    Forrest K. Ferrari;Thaddeus Samulski;Thomas Shenk;Richard Jude Samulski

  • Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo.

    D M McCarty;H Fu;P E Monahan;C E Toulson;C E Toulson

  • Production and characterization of adeno-associated viral vectors

    Joshua C Grieger;Vivian W Choi;Vivian W Choi;R Jude Samulski

  • Dystrophin Immunity in Duchenne's Muscular Dystrophy

    Jerry R. Mendell;Katherine Campbell;Katherine Campbell;Louise Rodino-Klapac;Louise Rodino-Klapac;Zarife Sahenk;Zarife Sahenk

  • Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors.

    Jeffrey S. Bartlett;Rose Wilcher;R. Jude Samulski

  • Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells

    Richard J. Samulski;Kenneth I. Berns;Ming Tan;Nicholas Muzyczka

  • Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.

    Thomas J Mccown;Xiao Xiao;Juan Li;George R Breese

  • A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication.

    R. J. Samulski;L. S. Chang;Thomas Eugene Shenk

  • Integration of Adeno-Associated Virus (AAV) and Recombinant AAV Vectors

    Douglas M. McCarty;Samuel M. Young;R. Jude Samulski

  • AAV-Mediated Gene Therapy for Research and Therapeutic Purposes.

    R Jude Samulski;Nicholas Muzyczka

Frequent Co-Authors

Xiao Xiao
Xiao Xiao University of North Carolina at Chapel Hill
Aravind Asokan
Aravind Asokan Duke University
Nicholas Muzyczka
Nicholas Muzyczka University of Florida
Juan Li
Juan Li University of North Carolina at Chapel Hill
Kenneth I. Berns
Kenneth I. Berns University of Florida
Mavis Agbandje-McKenna
Mavis Agbandje-McKenna University of Florida
Ronald G. Thurman
Ronald G. Thurman University of North Carolina at Chapel Hill
Arun Srivastava
Arun Srivastava University of Florida
Roger J. Hajjar
Roger J. Hajjar Icahn School of Medicine at Mount Sinai
Mark H. Tuszynski
Mark H. Tuszynski University of California, San Diego

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