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Medicine

D-Index
92
Citations
34538
World Ranking
11219
National Ranking
5761

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Matthew J. During is affiliated with The Ohio State University in the United States. Their research spans fields primarily within Medicine and Biochemistry, Genetics and Molecular Biology. Specific subfields contributing to their work include Molecular Biology, Surgery, Psychiatry and Mental Health, Oncology, and Pediatrics, Perinatology and Child Health.

The scientist's research focuses on several main topics, including:

  • Cholesterol and Lipid Metabolism
  • Epilepsy research and treatment
  • Drug Transport and Resistance Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Receptor Mechanisms and Signaling
  • Steroid Chemistry and Biochemistry
  • Genetic Syndromes and Imprinting

Matthew J. During has contributed to publications in a range of journals. Frequent publication venues include:

  • Neurology
  • Epilepsia
  • Scientific Reports
  • Epilepsy Research
  • Neurobiology of Disease

Recent papers authored or coauthored by Matthew J. During include:

  • "Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice" (2020, Scientific Reports)
  • "Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice" (2021, Epilepsia)
  • "A phase 1b/2a study of soticlestat as adjunctive therapy in participants with developmental and/or epileptic encephalopathies" (2021, Epilepsy Research)
  • "The STARS Phase 2 Study" (2020, Neurology)
  • "OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats" (2021, Epilepsia)

Frequent coauthors in the scientist's publications include:

  • Toshiya Nishi
  • Jonathan J. Halford
  • Dimitrios Arkilo
  • Mahnaz Asgharnejad
  • Celia Zinger

Matthew J. During was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2007.

Best Publications

  • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

    Michael G. Kaplitt;Paola Leone;Richard J. Samulski;Xiao Xiao

  • Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.

    Michael G Kaplitt;Andrew Feigin;Andrew Feigin;Chengke Tang;Helen L Fitzsimons

  • Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain

    M.J. During;D.D. Spencer

  • VEGF links hippocampal activity with neurogenesis, learning and memory.

    Lei Cao;Xiangyang Jiao;David S Zuzga;Yuhong Liu

  • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

    Matthew J During;Lei Cao;David S Zuzga;Jeremy S Francis

  • Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.

    Deborah Young;Patricia A. Lawlor;Paola Leone;Michael Dragunow

  • Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

    Robert E MacLaren;Robert E MacLaren;Markus Groppe;Markus Groppe;Alun R Barnard;Charles L Cottriall

  • The endocannabinoid system controls key epileptogenic circuits in the hippocampus.

    Krisztina Monory;Federico Massa;Federico Massa;Michaela Egertová;Matthias Eder

  • Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach

    Wei Lu;Yun Shi;A. Jackson;Kirsten Bjorgan

  • AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

    Peter A LeWitt;Ali R Rezai;Maureen A Leehey;Steven G Ojemann

  • Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Heiko Johnen;Shu Lin;Tamara Kuffner;David A. Brown

  • Adenosine: a potential mediator of seizure arrest and postictal refractoriness.

    Matthew J. During;Dennis D. Spencer

  • Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase.

    Matthew J. During;Janice R. Naegele;Karen L. O'Malley;Alfred I. Geller

  • Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release

    Walter P Borg;Robert S Sherwin;Matthew J During;Monica A Borg

  • White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

    Lei Cao;Eugene Y. Choi;Xianglan Liu;Adam Martin

  • Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.

    Omar Akil;Rebecca P. Seal;Kevin Burke;Chuansong Wang

  • Hippocampal GABA transporter function in temporal-lobe epilepsy

    Matthew J. During;Kathryn M Ryder;Dennis D. Spencer

  • Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition

    Lei Cao;Lei Cao;Xianglan Liu;En-Ju D. Lin;Chuansong Wang

  • Subthalamic GAD gene therapy in a Parkinson's disease rat model.

    Jia Luo;Michael G. Kaplitt;Helen L. Fitzsimons;David S. Zuzga

  • Controlled release of dopamine from a polymeric brain implant: In vivo characterization

    Matthew J. During;Matthew J. During;Andrew Freese;Bernhard A. Sabel;W. Mark Saltzman;W. Mark Saltzman

Frequent Co-Authors

Matthias Klugmann
Matthias Klugmann University of New South Wales
Herbert Herzog
Herbert Herzog Garvan Institute of Medical Research
Amanda Sainsbury
Amanda Sainsbury University of Western Australia
Mike Dragunow
Mike Dragunow University of Auckland
Chris Ward
Chris Ward Newcastle University
David Eidelberg
David Eidelberg Feinstein Institute for Medical Research
Annamaria Vezzani
Annamaria Vezzani Mario Negri Institute for Pharmacological Research
Karen L. O'Malley
Karen L. O'Malley Washington University in St. Louis
Karen K. Szumlinski
Karen K. Szumlinski University of California, Santa Barbara
Michael J. O'Connor
Michael J. O'Connor Thomas Jefferson University Hospital

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