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Thomas Perlmann

Thomas Perlmann

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Molecular Biology

D-Index
68
Citations
22250
World Ranking
1499
National Ranking
24

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thomas Perlmann is affiliated with the Karolinska Institute in Sweden, engaging primarily in research within biochemistry, genetics, and molecular biology, as well as neuroscience. Their scientific outputs cover a range of molecular and cellular investigations related to neurobiology and developmental processes.

The main fields of study in Perlmann's work include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, the focus extends into several subfields of study:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Genetics
  • Developmental Neuroscience
  • Neurology

Key topics emphasized in their research are:

  • Single-cell and spatial transcriptomics
  • Neurogenesis and neuroplasticity mechanisms
  • Pluripotent Stem Cells Research
  • Genetics and Neurodevelopmental Disorders
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Parkinson's Disease Mechanisms and Treatments

Perlmann has multiple recent publications illustrating these interests. Selected papers include:

  • "Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease," 2020, Nature Communications
  • "Schwann cell precursors represent a neural crest-like state with biased multipotency," 2022, The EMBO Journal
  • "CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment," 2020, Nature Communications
  • "Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model," 2023, eLife
  • "Disease Duration Influences Gene Expression in Neuromelanin-Positive Cells From Parkinson's Disease Patients," 2021, Frontiers in Molecular Neuroscience

The frequent publication venues for Perlmann's work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • eLife
  • npj Parkinson s Disease
  • The EMBO Journal

Collaborations play a significant role in Perlmann's research output. Notable frequent co-authors include:

  • Linda Gillberg
  • Per Svenningsson
  • Behzad Yaghmaeian Salmani
  • Katarína Tiklová
  • Laura Lahti

Among recognitions, Perlmann is a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

    Steven A Kliewer;John T Moore;Laura Wade;Jeff L Staudinger

  • IDENTIFICATION OF A NUCLEAR RECEPTOR THAT IS ACTIVATED BY FARNESOL METABOLITES

    Barry M Forman;Elizabeth Goode;Jasmine Chen;Anthony E Oro

  • Dopamine neuron agenesis in Nurr1-deficient mice.

    Rolf H. Zetterström;Ludmila Solomin;Ludmila Solomin;Ludmila Solomin;Lottie Jansson;Lottie Jansson;Lottie Jansson;Barry J. Hoffer;Barry J. Hoffer;Barry J. Hoffer

  • Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

    Alexander Mata de Urquiza;Suya Liu;Maria Sjöberg;Rolf H. Zetterström

  • Structural determinants of nuclear receptor assembly on DNA direct repeats.

    Fraydoon Rastinejad;Thomas Perlmann;Thomas Perlmann;Ronald M. Evans;Paul B. Sigler

  • Identification of Intrinsic Determinants of Midbrain Dopamine Neurons

    Elisabet Andersson;Ulrika Tryggvason;Qiaolin Deng;Stina Friling

  • Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors.

    Zhulun Wang;Gérard Benoit;Jinsong Liu;Srividya Prasad

  • A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

    Thomas Perlmann;Lottie Jansson

  • Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.

    Joseph Wagner;Peter Åkerud;Diogo S. Castro;Pontus C. Holm

  • Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin.

    Milos Pekny;Clas B. Johansson;Camilla Eliasson;Josefina Stakeberg

  • Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system.

    Rolf H Zetterström;Reg Williams;Thomas Perlmann;Lars Olson

  • Determinants for selective RAR and TR recognition of direct repeat HREs.

    T Perlmann;P N Rangarajan;K Umesono;R M Evans

  • Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

    Banafsheh Kadkhodaei;Takehito Ito;Eliza Joodmardi;Bengt Mattsson

  • The establishment of neuronal properties is controlled by Sox4 and Sox11

    Maria Bergsland;Martin Werme;Michal Malewicz;Thomas Perlmann

  • Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.

    Johan Lengqvist;Johan Lengqvist;Alexander Mata de Urquiza;Ann Charlotte Bergman;Timothy M. Willson

  • Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.

    T Perlmann;O Wrange

  • α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

    Mickael Decressac;Banafsheh Kadkhodaei;Bengt Mattsson;Ariadna Laguna

  • Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity.

    D. L. Misner;S. Jacobs;Y. Shimizu;A. M. de Urquiza

  • Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.

    R H Zetterström;L Solomin;T Mitsiadis;L Olson

  • Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid.

    R H Zetterström;E Lindqvist;A Mata de Urquiza;A Tomac

Frequent Co-Authors

Johan Ericson
Johan Ericson Karolinska Institute
Lars Olson
Lars Olson Karolinska Institute
Ernest Arenas
Ernest Arenas Karolinska Institute
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Evan Y. Snyder
Evan Y. Snyder Discovery Institute
Rickard Sandberg
Rickard Sandberg Karolinska Institute
Anders Björklund
Anders Björklund Lund University
Malin Parmar
Malin Parmar Lund University
William J. Griffiths
William J. Griffiths Swansea University
Bertrand Joseph
Bertrand Joseph Karolinska Institute

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